6PYF

Sex Hormone-binding globulin mutant E176K in complex with Estradiol

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6pyfa_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Laminin G-like module	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Laminin_G_1	e6pyfA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00054	Laminin G domain (Laminin_G_1)	Laminin G domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sex hormone-binding globulin	binding hormone binding androgen binding organic cyclic compound binding steroid binding lipid binding	-	cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR001791	Laminin G domain	Domain
A	IPR051145	Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P04278	metabolic syndrome X type 2 diabetes mellitus erectile dysfunction prostate cancer uterine corpus leiomyoma Neoplasm Invasiveness alcohol abuse aspiration pneumonitis tinea corporis dermatitis herpetiformis proctitis Hodgkins lymphoma atopic eczema triple-negative breast carcinoma hyperandrogenism metabolic syndrome X type 2 diabetes mellitus erectile dysfunction prostate cancer uterine corpus leiomyoma Neoplasm Invasiveness alcohol abuse aspiration pneumonitis tinea corporis dermatitis herpetiformis proctitis Hodgkins lymphoma atopic eczema triple-negative breast carcinoma hyperandrogenism autoimmune thrombocytopenic purpura psoriatic arthritis hypogonadotropic hypogonadism mycosis fungoides acne rheumatic heart disease IgA glomerulonephritis breast fibrocystic disease neuroblastoma acquired thrombocytopenia sarcoidosis infertility disorder otitis externa adrenocortical insufficiency chronic beryllium disease skin basal cell carcinoma iridocyclitis juvenile idiopathic arthritis contact dermatitis eye disease amenorrhea corneal ulcer cryptorchidism granuloma annulare anovulation tenosynovitis maturity-onset diabetes of the young asthma tinea pedis dermatophytosis of groin and perianal area atrial fibrillation Diamond-Blackfan anemia hyperinsulinism autoimmune disease multiple sclerosis hypopituitarism blepharoconjunctivitis rheumatoid arthritis inborn carbohydrate metabolic disorder bursitis endometriosis acute lymphoblastic leukemia pemphigus erythema multiforme inherited aplastic anemia iritis polycystic ovary syndrome esophageal squamous cell carcinoma skin disease keratitis synovitis glioblastoma angioedema systemic lupus erythematosus cutaneous melanoma primary cutaneous T-cell lymphoma hemorrhoid aphthous stomatitis thyroiditis melanoma primary ovarian failure atopic conjunctivitis trichinosis ulcerative colitis miliary tuberculosis psoriasis hypogonadism autoimmune hemolytic anemia uveitis musculoskeletal system disease idiopathic acute eosinophilic pneumonia brain glioma nephrotic syndrome endometrial carcinoma acquired hyperprolactinemia rosacea obesity disorder epicondylitis Addison disease seborrheic dermatitis inflammatory bowel disease physiological sexual disorder congenital adrenal hyperplasia exanthem allergic rhinitis Klinefelter syndrome postmenopausal osteoporosis Crohn disease gout ankylosing spondylitis tendinitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.