6QTB | pdb_00006qtb

Crystal structure of Rea1-MIDAS/Ytm1-UBL complex from Chaetomium thermophilum

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	VWA	e6qtbA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)
C [auth D]	VWA	e6qtbD1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)
B	NLE	e6qtbB1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: NLE	ECOD (1.6)
D [auth E]	NLE	e6qtbE1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: NLE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D [auth E]	PF08154	NLE (NUC135) domain (NLE)	NLE (NUC135) domain	This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth D]	Midasin,Midasin	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity cation binding metal ion binding	establishment of organelle localization cellular localization ribonucleoprotein complex biogenesis nucleocytoplasmic transport transport nuclear transport ribosomal subunit export from nucleus ribosomal large subunit export from nucleus intracellular transport establishment of localization protein-containing complex localization cellular component biogenesis localization ribosome biogenesis organelle localization establishment of organelle localization cellular localization ribonucleoprotein complex biogenesis nucleocytoplasmic transport transport nuclear transport ribosomal subunit export from nucleus ribosomal large subunit export from nucleus intracellular transport establishment of localization protein-containing complex localization cellular component biogenesis localization ribosome biogenesis organelle localization establishment of localization in cell cellular process cellular component organization or biogenesis nuclear export ribosome localization organelle assembly protein-containing complex organization membraneless organelle assembly ribosomal large subunit biogenesis protein-RNA complex assembly cellular component organization organelle organization protein-RNA complex organization cellular component assembly ribosomal large subunit assembly protein-containing complex assembly ribosome assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen preribosome protein-containing complex ribonucleoprotein complex preribosome, large subunit precursor nucleoplasm
B, D [auth E]	Ribosome biogenesis protein YTM1	ribonucleoprotein complex binding protein-containing complex binding binding	maturation of 5.8S rRNA ribonucleoprotein complex biogenesis RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of 5.8S rRNA ribonucleoprotein complex biogenesis RNA metabolic process primary metabolic process rRNA processing gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component biogenesis RNA biosynthetic process ribosome biogenesis nucleic acid biosynthetic process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) biosynthetic process metabolic process cellular process macromolecule metabolic process cellular component organization or biogenesis RNA processing rRNA metabolic process ribosomal large subunit biogenesis maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) maturation of LSU-rRNA	preribosome protein-containing complex ribonucleoprotein complex preribosome, large subunit precursor membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen preribosome protein-containing complex ribonucleoprotein complex preribosome, large subunit precursor membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen nuclear protein-containing complex intracellular membraneless organelle nucleolus 90S preribosome PeBoW complex membraneless organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth D]	IPR048617	Midasin, lid domain 4	Domain
A, C [auth D]	IPR011704	ATPase, dynein-related, AAA domain	Domain
A, C [auth D]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
A, C [auth D]	IPR040848	Midasin, AAA lid domain 7	Domain
A, C [auth D]	IPR012099	Midasin	Family
A, C [auth D]	IPR003593	AAA+ ATPase domain	Domain
A, C [auth D]	IPR041190	Midasin AAA lid domain 5	Domain
A, C [auth D]	IPR002035	von Willebrand factor, type A	Domain
A, C [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, D [auth E]	IPR019775	WD40 repeat, conserved site	Conserved Site
B, D [auth E]	IPR012972	NLE	Domain
B, D [auth E]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B, D [auth E]	IPR001680	WD40 repeat	Repeat
B, D [auth E]	IPR028599	WD repeat WDR12/Ytm1	Family
B, D [auth E]	IPR020472	G-protein beta WD-40 repeat	Repeat
B, D [auth E]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.