Annotations: 6S7O

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Ost4	e6s7oB1	A: extended segments	X: Oligosaccharyltransferase subunit ost4p (From Topology)	H: Oligosaccharyltransferase subunit ost4p (From Topology)	T: Oligosaccharyltransferase subunit ost4p	F: Ost4	ECOD (1.6)
A	STT3	e6s7oA2	A: alpha bundles	X: STT3/PglB/AglB transmembrane domain (From Topology)	H: STT3/PglB/AglB transmembrane domain (From Topology)	T: STT3/PglB/AglB transmembrane domain	F: STT3	ECOD (1.6)
A	archaeo_STT3_1st	e6s7oA1	A: a/b three-layered sandwiches	X: STT3/PglB/AglB core domain (From Topology)	H: STT3/PglB/AglB core domain (From Topology)	T: STT3/PglB/AglB core domain	F: archaeo_STT3_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF10215	Oligosaccaryltransferase (Ost4)	Oligosaccaryltransferase	-	Family
C	PF05251	Oligosaccharyltransferase subunit 5 (Ost5)	Oligosaccharyltransferase subunit 5	-	Family
A	PF02516	Oligosaccharyl transferase STT3, N-terminal (STT3)	Oligosaccharyl transferase STT3, N-terminal	This entry consists of the oligosaccharyl transferase STT3 subunit and related proteins. The STT3 subunit is part of the oligosaccharyl transferase (OTase) complex of proteins and is required for its activity [2]. In eukaryotes, OTase transfers a l ...	This entry consists of the oligosaccharyl transferase STT3 subunit and related proteins. The STT3 subunit is part of the oligosaccharyl transferase (OTase) complex of proteins and is required for its activity [2]. In eukaryotes, OTase transfers a lipid-linked core-oligosaccharide to selected asparagine residues in the ER [2]. In the archaea STT3 occurs alone, rather than in an OTase complex, and is required for N-glycosylation of asparagines [3-4]. This entry represents the N-terminal domain, consisting of transmembrane helices.	Domain
D	PF02109	DAD family (DAD)	DAD family	-	Family
E	PF04597	Ribophorin I (Ribophorin_I)	Ribophorin I	-	Family
G	PF03345	OST48, N-terminal domain (OST48_N)	Oligosaccharyltransferase 48 kDa subunit beta	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4	-	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process protein N-linked glycosylation via asparagine	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
C	Transmembrane protein 258	protein-containing complex binding binding oligosaccharyltransferase complex binding	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process apoptotic process cell death programmed cell death epithelial cell apoptotic process response to stimulus defense response response to stress inflammatory response cellular response to stimulus cellular response to stress response to endoplasmic reticulum stress	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
F	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2	-	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process protein N-linked glycosylation via asparagine	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane nucleus membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
A	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A	cation binding ion binding binding metal ion binding small molecule binding oligosaccharyl transferase activity glycosyltransferase activity dolichyl-diphosphooligosaccharide-protein glycotransferase activity transferase activity hexosyltransferase activity catalytic activity	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process post-translational protein modification co-translational protein modification protein N-linked glycosylation via asparagine	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
D	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process apoptotic process cell death programmed cell death regulation of protein stability biological regulation regulation of biological quality developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development protein N-linked glycosylation via asparagine regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
E	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	RNA binding binding organic cyclic compound binding nucleic acid binding	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process protein N-linked glycosylation via asparagine	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle protein-containing complex catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle protein-containing complex catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane pigment granule intracellular vesicle melanosome cytoplasmic vesicle vesicle rough endoplasmic reticulum
G	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit	enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process multicellular organismal process T cell activation immune system process cell activation lymphocyte activation leukocyte activation regulation of protein stability biological regulation regulation of biological quality response to peptide response to stimulus response to chemical response to cytokine protein N-linked glycosylation via asparagine	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane intracellular vesicle lytic vacuole bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle lysosome vacuolar membrane azurophil granule vacuole lytic vacuole membrane cytoplasmic vesicle membrane lysosomal membrane secretory granule primary lysosome secretory vesicle azurophil granule membrane secretory granule membrane cell periphery plasma membrane
H	Oligosaccharyltransferase complex subunit OSTC	-	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process protein N-linked glycosylation via asparagine	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex organelle subcompartment oligosaccharyltransferase complex membrane membrane protein complex intracellular membrane-bounded organelle transferase complex endomembrane system endoplasmic reticulum subcompartment intracellular organelle cellular anatomical structure organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR051307	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4	Family
B	IPR018943	Oligosaccaryltransferase	Family
B	IPR036330	Oligosaccharyltransferase subunit ost4p superfamily	Homologous Superfamily
C	IPR007915	Oligosaccharyltransferase complex subunit	Family
F	IPR008814	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1	Family
A	IPR003674	Oligosaccharyl transferase, STT3 subunit	Family
A	IPR048307	Oligosaccharyl transferase STT3, N-terminal domain	Domain
A	IPR054479	AglB-like, core domain	Domain
D	IPR003038	DAD/Ost2	Family
E	IPR007676	Ribophorin I	Family
G	IPR005013	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit	Family
H	IPR021149	Oligosaccharyl transferase complex, subunit OST3/OST6	Family
H	IPR042416	Oligosaccharyltransferase complex subunit OSTC	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P0C6T2	exocrine pancreatic carcinoma ovarian cancer glioblastoma pancreatic ductal adenocarcinoma malignant pancreatic neoplasm
C	Pharos: P61165	Crohn disease metabolic syndrome X primitive neuroectodermal tumor aortic stenosis bipolar I disorder glioblastoma laryngeal squamous cell carcinoma medulloblastoma osteosarcoma psoriasis asthma colorectal adenoma endogenous depression inflammatory bowel disease lung cancer Crohn disease metabolic syndrome X primitive neuroectodermal tumor aortic stenosis bipolar I disorder glioblastoma laryngeal squamous cell carcinoma medulloblastoma osteosarcoma psoriasis asthma colorectal adenoma endogenous depression inflammatory bowel disease lung cancer ovarian cancer rheumatoid arthritis atypical teratoid rhabdoid tumor colorectal cancer gallbladder disease large cell medulloblastoma malignant glioma nasal cavity disease
F	Pharos: P04844	prostate cancer pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor dermatomyositis glioblastoma large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma ovarian cancer pilocytic astrocytoma Prostatic Neoplasms atypical teratoid rhabdoid tumor diabetes mellitus invasive ductal breast carcinoma lung adenocarcinoma prostate cancer pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor dermatomyositis glioblastoma large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma ovarian cancer pilocytic astrocytoma Prostatic Neoplasms atypical teratoid rhabdoid tumor diabetes mellitus invasive ductal breast carcinoma lung adenocarcinoma malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor subependymal giant cell astrocytoma breast cancer esophageal adenocarcinoma juvenile dermatomyositis lung cancer medulloblastoma osteosarcoma
A	Pharos: P46977	STT3A-CDG congenital disorder of glycosylation Gaucher disease intellectual disability malignant pancreatic neoplasm osteosarcoma cystic fibrosis glioblastoma lung adenocarcinoma medulloblastoma ovarian cancer exocrine pancreatic carcinoma inborn errors of metabolism malignant ependymoma non-small cell lung carcinoma STT3A-CDG congenital disorder of glycosylation Gaucher disease intellectual disability malignant pancreatic neoplasm osteosarcoma cystic fibrosis glioblastoma lung adenocarcinoma medulloblastoma ovarian cancer exocrine pancreatic carcinoma inborn errors of metabolism malignant ependymoma non-small cell lung carcinoma plasma cell myeloma
D	Pharos: P61803	acute myeloid leukemia lung cancer plasma cell myeloma diabetes mellitus lymphoplasmacytic lymphoma glioblastoma ovarian cancer
E	Pharos: P04843	astrocytic tumor chronic kidney disease multiple sclerosis plasma cell myeloma attention deficit hyperactivity disorder, inattentive type glioblastoma osteosarcoma breast carcinoma lung adenocarcinoma ovarian cancer
G	Pharos: P39656	DDOST-CDG congenital disorder of glycosylation Sjogren syndrome astrocytic tumor inborn errors of metabolism lung adenocarcinoma malignant ependymoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor diabetes mellitus intellectual disability lung cancer malignant glioma ovarian cancer DDOST-CDG congenital disorder of glycosylation Sjogren syndrome astrocytic tumor inborn errors of metabolism lung adenocarcinoma malignant ependymoma osteosarcoma pilocytic astrocytoma atypical teratoid rhabdoid tumor diabetes mellitus intellectual disability lung cancer malignant glioma ovarian cancer plasma cell myeloma glioblastoma large cell medulloblastoma lymphoplasmacytic lymphoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm
H	Pharos: Q9NRP0	acute myeloid leukemia large cell medulloblastoma Malignant neoplasm of breast ovarian cancer atypical teratoid rhabdoid tumor malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma glioblastoma malignant glioma osteosarcoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H	OPM	Transmembrane	Alpha-helical polytopic	Glycosyl transferase GT-C superfamily	Oligosaccharyltransferase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Oligosaccharyltransferases (OST)	Oligosaccharyltransferase A (OST-A)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.