6VZD | pdb_00006vzd

N-terminal domain of mouse surfactant protein B (K46E/R51E mutant) with bound lipid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6vzda_	All alpha proteins	Saposin-like	Saposin	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B [auth E]	d6vzde_	All alpha proteins	Saposin-like	Saposin	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C [auth B]	d6vzdb_	All alpha proteins	Saposin-like	Saposin	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D [auth C]	d6vzdc_	All alpha proteins	Saposin-like	Saposin	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SapB_2	e6vzdA1	A: alpha arrays	X: Saposin-like	H: Saposin-like (From Topology)	T: Saposin-like	F: SapB_2	ECOD (1.6)
B [auth E]	SapB_2	e6vzdE1	A: alpha arrays	X: Saposin-like	H: Saposin-like (From Topology)	T: Saposin-like	F: SapB_2	ECOD (1.6)
C [auth B]	SapB_2	e6vzdB1	A: alpha arrays	X: Saposin-like	H: Saposin-like (From Topology)	T: Saposin-like	F: SapB_2	ECOD (1.6)
D [auth C]	SapB_2	e6vzdC1	A: alpha arrays	X: Saposin-like	H: Saposin-like (From Topology)	T: Saposin-like	F: SapB_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.225.10	Mainly Alpha	Orthogonal Bundle	NK-Lysin	Saposin-like	CATH (utative)
B [auth E]	1.10.225.10	Mainly Alpha	Orthogonal Bundle	NK-Lysin	Saposin-like	CATH (utative)
C [auth B]	1.10.225.10	Mainly Alpha	Orthogonal Bundle	NK-Lysin	Saposin-like	CATH (utative)
D [auth C]	1.10.225.10	Mainly Alpha	Orthogonal Bundle	NK-Lysin	Saposin-like	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth E], C [auth B], D [auth C]	PF05184	Saposin-like type B, region 1 (SapB_1)	Saposin-like type B, region 1	Saposin B is a small non-enzymatic glycoprotein required for the breakdown of cerebroside sulphates (sulphatides) in lysosomes. Saposin B contains three intramolecular disulphide bridges, exists as a dimer and is remarkably heat, protease, and pH sta ...	Saposin B is a small non-enzymatic glycoprotein required for the breakdown of cerebroside sulphates (sulphatides) in lysosomes. Saposin B contains three intramolecular disulphide bridges, exists as a dimer and is remarkably heat, protease, and pH stable. The crystal structure of human saposin B reveals an unusual shell-like dimer consisting of a monolayer of alpha-helices enclosing a large hydrophobic cavity [1,2]. It is one of the most studied members of the saposin protein family and it is involved in the hydrolysis of glycolipids and glycerolipids. SapB is unique in the saposin family in that it facilitates degradation by interacting with the substrate, not the enzymes [3].	Domain
A, B [auth E], C [auth B], D [auth C]	PF03489	Saposin-like type B, region 2 (SapB_2)	Saposin-like type B, region 2	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth E], C [auth B], D [auth C]	Pulmonary surfactant-associated protein B	-	membrane lipid metabolic process sphingolipid metabolic process primary metabolic process metabolic process cellular process lipid metabolic process multicellular organismal process respiratory gaseous exchange by respiratory system	cellular anatomical structure membrane extracellular region cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole cellular anatomical structure membrane extracellular region cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth E], C [auth B], D [auth C]	IPR011001	Saposin-like	Homologous Superfamily
A, B [auth E], C [auth B], D [auth C]	IPR008373	Saposin	Family
A, B [auth E], C [auth B], D [auth C]	IPR007856	Saposin-like type B, region 1	Domain
A, B [auth E], C [auth B], D [auth C]	IPR008139	Saposin B type domain	Domain
A, B [auth E], C [auth B], D [auth C]	IPR051428	Sphingolipid Activators and Surfactant Proteins	Family
A, B [auth E], C [auth B], D [auth C]	IPR008138	Saposin B type, region 2	Domain
A, B [auth E], C [auth B], D [auth C]	IPR003119	Saposin A-type domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B [auth E], C [auth B], D [auth C]	OPM	Monotopic/peripheral	All alpha monotopic/peripheral	Saposin-like	Saposin

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.