7G1H

Crystal Structure of human FABP4 in complex with 2-(3,5-ditert-butyl-2-hydroxyphenyl)-3,3,3-trifluoro-2-hydroxypropanoic acid, i.e. SMILES [C@@](c1c(c(cc(c1)C(C)(C)C)C(C)(C)C)O)(C(F)(F)F)(C(=O)O)O with IC50=0.202 microM

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lipocalins	8042368	3001332	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00061	Lipocalin / cytosolic fatty-acid binding protein family (Lipocalin)	Lipocalin / cytosolic fatty-acid binding protein family	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid ...	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Fatty acid-binding protein, adipocyte	protein binding binding signaling receptor binding hormone receptor binding fatty acid binding organic acid binding ion binding anion binding long-chain fatty acid binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding long-chain fatty acid transmembrane transporter activity protein binding binding signaling receptor binding hormone receptor binding fatty acid binding organic acid binding ion binding anion binding long-chain fatty acid binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding long-chain fatty acid transmembrane transporter activity lipid transporter activity lipid transmembrane transporter activity fatty acid transmembrane transporter activity transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization response to peptide cellular response to tumor necrosis factor response to stimulus response to chemical response to cytokine cellular response to cytokine stimulus response to tumor necrosis factor multicellular organismal process homeostatic process positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process positive regulation of cellular process cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to lithium ion cellular response to lithium ion response to metal ion regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external biotic stimulus response to biotic stimulus long-chain fatty acid transport developmental process fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation sterol homeostasis chemical homeostasis cholesterol homeostasis lipid homeostasis white fat cell differentiation	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle lipid droplet intracellular organelle intracellular anatomical structure membraneless organelle extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle lipid droplet intracellular organelle intracellular anatomical structure membraneless organelle intracellular membraneless organelle cytoplasm cytosol nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000463	Cytosolic fatty-acid binding	Domain
A	IPR012674	Calycin	Homologous Superfamily
A	IPR031259	Intracellular lipid binding protein	Family
A	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P15090	carcinoma Mammary Neoplasms, Experimental sarcomatoid carcinoma contact dermatitis lung carcinoma mammary neoplasms, animal nephrosclerosis osteosarcoma adrenal cortex adenoma pancreatic intraductal papillary-mucinous neoplasm atopic eczema psoriasis type 2 diabetes mellitus ductal breast carcinoma in situ interstitial cystitis carcinoma Mammary Neoplasms, Experimental sarcomatoid carcinoma contact dermatitis lung carcinoma mammary neoplasms, animal nephrosclerosis osteosarcoma adrenal cortex adenoma pancreatic intraductal papillary-mucinous neoplasm atopic eczema psoriasis type 2 diabetes mellitus ductal breast carcinoma in situ interstitial cystitis lung adenocarcinoma non-small cell lung carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer undifferentiated carcinoma Emery-Dreifuss muscular dystrophy invasive ductal breast carcinoma lung cancer myopathy obesity disorder pancreatic intraductal papillary-mucinous carcinoma periodontitis breast carcinoma Sjogren syndrome Duchenne muscular dystrophy inborn carbohydrate metabolic disorder kidney disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.