Annotations: 7CEB

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Integrin_alpha2_1st	e7cebA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Integrin_alpha2_1st	ECOD (1.6)
A	FG-GAP_1st	e7cebA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: FG-GAP_1st	ECOD (1.6)
B	INB	e7cebB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: INB	ECOD (1.6)
B	Integrin_beta	e7cebB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: Integrin_beta	ECOD (1.6)
C	V-set_12	e7cebC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
D	Mst1_SARAH,V-set	e7cebD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Mst1_SARAH,V-set	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C	Heavy Chain	IGHV5	-	integrin beta-1	SAbDab (2025-05-09)
D	Light Chain	IGKV4	Kappa	integrin beta-1	SAbDab (2025-05-09)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01839	FG-GAP repeat (FG-GAP)	FG-GAP repeat	-	Repeat
A	PF08441	Integrin alpha Ig-like domain 1 (Integrin_A_Ig_1)	Integrin alpha Ig-like domain 1	This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of an immunoglobulin-like domain.	Domain
B	PF00362	Integrin beta chain VWA domain (Integrin_beta)	Integrin beta chain VWA domain	Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1]. This domain corresponds to the integrin beta VWA domain.	Domain
D	PF11629	C terminal SARAH domain of Mst1 (Mst1_SARAH)	C terminal SARAH domain of Mst1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Integrin alpha-6	neuregulin binding protein binding binding growth factor binding insulin-like growth factor binding insulin-like growth factor I binding extracellular matrix binding laminin binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding cadherin binding cation binding neuregulin binding protein binding binding growth factor binding insulin-like growth factor binding insulin-like growth factor I binding extracellular matrix binding laminin binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding cadherin binding cation binding ion binding metal ion binding small molecule binding	cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process developmental process cellular developmental process ectoderm development cell differentiation ectodermal cell differentiation anatomical structure development tissue development regulation of biological process regulation of cellular process regulation of cell-substrate adhesion cell adhesion cell-matrix adhesion cell-substrate adhesion cellular process developmental process cellular developmental process ectoderm development cell differentiation ectodermal cell differentiation anatomical structure development tissue development regulation of biological process regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process positive regulation of cell-substrate adhesion positive regulation of cellular process positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity cellular response to stimulus integrin-mediated signaling pathway cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death cell adhesion mediated by integrin multicellular organism development multicellular organismal process nail development limb development appendage development regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cell projection organization cell development neuron projection development cellular component organization neurogenesis neuron differentiation positive regulation of neuron projection development positive regulation of cell projection organization cellular component organization or biogenesis system development plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-substrate junction assembly cell-substrate junction organization leukocyte migration immune system process cell migration cell motility positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion positive regulation of phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of phosphate metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorus metabolic process metabolic process regulation of phosphorylation phosphorus metabolic process regulation of metabolic process negative regulation of signaling negative regulation of biological process regulation of signal transduction extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process regulation of signaling negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of cell communication regulation of apoptotic signaling pathway cell-cell adhesion anatomical structure morphogenesis skin development skin morphogenesis animal organ development animal organ morphogenesis positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex membrane protein complex cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex membrane protein complex integrin alpha6-beta4 complex receptor complex integrin complex plasma membrane signaling receptor complex protein complex involved in cell adhesion cell-cell junction adherens junction cell projection actin-based cell projection filopodium plasma membrane bounded cell projection integrin alpha6-beta1 complex
B	Integrin beta-1	cell adhesion molecule binding cadherin binding protein binding binding protein-containing complex binding protein tyrosine kinase binding kinase binding enzyme binding protein kinase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding cell adhesion molecule binding cadherin binding protein binding binding protein-containing complex binding protein tyrosine kinase binding kinase binding enzyme binding protein kinase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protease binding magnesium ion binding collagen binding collagen binding involved in cell-matrix adhesion cell adhesion mediator activity cell-matrix adhesion mediator activity molecular transducer activity coreceptor activity signaling receptor activity extracellular matrix binding laminin binding fibronectin binding virus receptor activity exogenous protein binding protein heterodimerization activity protein dimerization activity integrin binding signaling receptor binding integrin binding involved in cell-matrix adhesion cytoskeletal protein binding actin binding	response to stimulus response to activity response to muscle activity regulation of tube diameter multicellular organismal process regulation of biological process system process regulation of tube size regulation of system process negative regulation of biological process biological regulation negative regulation of vasoconstriction circulatory system process regulation of blood circulation response to stimulus response to activity response to muscle activity regulation of tube diameter multicellular organismal process regulation of biological process system process regulation of tube size regulation of system process negative regulation of biological process biological regulation negative regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality negative regulation of multicellular organismal process vasoconstriction blood circulation regulation of anatomical structure size lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular process cellular component organization or biogenesis cell projection assembly developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development myoblast differentiation positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane extracellular matrix organization extracellular structure organization external encapsulating structure organization heart development cardiac muscle tissue development cardiac muscle cell differentiation animal organ development muscle cell differentiation tissue development cardiocyte differentiation striated muscle tissue development circulatory system development multicellular organism development striated muscle cell differentiation muscle tissue development system development negative regulation of programmed cell death regulation of apoptotic process regulation of anoikis regulation of programmed cell death cell death negative regulation of anoikis negative regulation of apoptotic process anoikis negative regulation of cellular process apoptotic process programmed cell death muscle organ development cellular response to stimulus positive regulation of cell communication cellular response to growth factor stimulus positive regulation of signal transduction signaling regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus cellular response to endogenous stimulus signal transduction regulation of vascular endothelial growth factor signaling pathway enzyme-linked receptor protein signaling pathway regulation of signaling regulation of cellular response to vascular endothelial growth factor stimulus cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus positive regulation of vascular endothelial growth factor signaling pathway vascular endothelial growth factor signaling pathway regulation of response to stimulus regulation of cell communication cellular response to vascular endothelial growth factor stimulus response to growth factor positive regulation of signaling calcium-independent cell-matrix adhesion cell adhesion cell-matrix adhesion cell-substrate adhesion response to fibroblast growth factor positive regulation of fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway catabolic process regulation of catabolic process regulation of collagen metabolic process collagen catabolic process regulation of collagen catabolic process metabolic process collagen metabolic process regulation of metabolic process CD40 signaling pathway establishment of organelle localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of localization establishment of cell polarity organelle organization mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process cytoskeleton organization cell fate specification myoblast fate specification cell fate commitment myoblast fate commitment wound healing epithelium development morphogenesis of an epithelium epiboly involved in wound healing morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis anatomical structure morphogenesis response to stress epiboly cell migration wound healing, spreading of cells cell motility response to wounding cell-cell adhesion leukocyte cell-cell adhesion defense response cellular defense response cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules axon extension axonogenesis developmental growth plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell growth cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis neuron projection extension developmental cell growth growth nervous system development axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis generation of neurons neuron development reactive gliosis inflammatory response neuroinflammatory response sexual reproduction reproductive process multicellular organismal reproductive process germ cell migration gamete generation positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity cell adhesion mediated by integrin basement membrane organization positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion maintenance of blood-brain barrier multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis formation of primary germ layer mesodermal cell differentiation mesoderm morphogenesis embryonic morphogenesis embryo development gastrulation anatomical structure formation involved in morphogenesis mesoderm formation mesoderm development cardiac muscle cell myoblast differentiation cardioblast differentiation stem cell differentiation cellular component assembly involved in morphogenesis membraneless organelle assembly striated muscle cell development cellular anatomical entity morphogenesis muscle cell development sarcomere organization actin filament-based process actomyosin structure organization actin cytoskeleton organization organelle assembly myofibril assembly supramolecular fiber organization leukocyte tethering or rolling leukocyte migration immune system process leukocyte adhesion to vascular endothelial cell cellular extravasation regulation of developmental process regulation of cell differentiation negative regulation of cell differentiation negative regulation of developmental process negative regulation of neuron differentiation regulation of neuron differentiation neuroblast proliferation cell population proliferation neural precursor cell proliferation positive regulation of response to wounding regulation of response to wounding positive regulation of wound healing regulation of response to stress regulation of wound healing import into cell receptor internalization transport receptor-mediated endocytosis endocytosis vesicle-mediated transport phagocytosis positive regulation of programmed cell death positive regulation of apoptotic process cell migration involved in sprouting angiogenesis blood vessel morphogenesis tube development endothelial cell migration angiogenesis sprouting angiogenesis vasculature development tube morphogenesis blood vessel endothelial cell migration blood vessel development embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development cellular response to low-density lipoprotein particle stimulus response to chemical response to lipoprotein particle response to nitrogen compound cellular response to lipoprotein particle stimulus cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle phase transition myoblast fusion cell-cell fusion myotube differentiation syncytium formation by plasma membrane fusion syncytium formation heterotypic cell-cell adhesion nitrogen compound transport carboxylic acid transmembrane transport positive regulation of amine transport regulation of amino acid transport organic acid transmembrane transport positive regulation of neurotransmitter transport carboxylic acid transport import across plasma membrane neurotransmitter transport organic acid transport transmembrane transport acidic amino acid transport positive regulation of glutamate uptake involved in transmission of nerve impulse regulation of amino acid import across plasma membrane regulation of transmembrane transport positive regulation of amino acid transport positive regulation of neurotransmitter uptake dicarboxylic acid transport L-alpha-amino acid transmembrane transport amino acid import across plasma membrane neurotransmitter uptake L-glutamate transmembrane transport positive regulation of L-glutamate import across plasma membrane amino acid transmembrane transport amino acid neurotransmitter reuptake L-amino acid transport L-glutamate import regulation of L-glutamate import across plasma membrane positive regulation of transmembrane transport regulation of amino acid transmembrane transport neurotransmitter reuptake regulation of glutamate uptake involved in transmission of nerve impulse regulation of neurotransmitter uptake L-glutamate import across plasma membrane organic anion transport regulation of transport glutamate reuptake regulation of neurotransmitter transport positive regulation of organic acid transport positive regulation of amino acid uptake involved in synaptic transmission amino acid transport amine transport positive regulation of transport regulation of organic acid transport regulation of amine transport regulation of amino acid uptake involved in synaptic transmission cell-cell adhesion mediated by integrin hemopoiesis B cell activation cell activation mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation leukocyte differentiation cardiac cell fate specification cardiac cell fate commitment regulation of fibroblast migration positive regulation of fibroblast migration fibroblast migration ameboidal-type cell migration integrin-mediated signaling pathway trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling spontaneous synaptic transmission regulation of spontaneous synaptic transmission head development brain development formation of radial glial scaffolds hindbrain radial glia guided cell migration central nervous system development hindbrain development cell migration in hindbrain cellular component disassembly regulation of synapse pruning regulation of cellular component organization cell junction disassembly synapse pruning regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization dendrite development dendrite morphogenesis regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction response to light stimulus learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation response to abiotic stimulus small GTPase-mediated signal transduction negative regulation of Rho protein signal transduction negative regulation of signaling regulation of small GTPase mediated signal transduction negative regulation of intracellular signal transduction Rho protein signal transduction negative regulation of cell communication negative regulation of response to stimulus negative regulation of small GTPase mediated signal transduction regulation of Rho protein signal transduction negative regulation of signal transduction regulation of vasculature development positive regulation of developmental process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process regulation of cell cycle positive regulation of nervous system development positive regulation of cell population proliferation regulation of neuroblast proliferation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of cell differentiation positive regulation of neurogenesis regulation of neural precursor cell proliferation positive regulation of cell development positive regulation of neural precursor cell proliferation regulation of cell population proliferation positive regulation of neuroblast proliferation regulation of potassium ion transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of inward rectifier potassium channel activity metal ion transport regulation of transporter activity monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport regulation of cation channel activity inorganic cation transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport	protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex receptor complex cell periphery cellular anatomical structure integrin complex plasma membrane signaling receptor complex integrin alpha1-beta1 complex protein complex involved in cell adhesion integrin alpha5-beta1 complex neuromuscular junction protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex receptor complex cell periphery cellular anatomical structure integrin complex plasma membrane signaling receptor complex integrin alpha1-beta1 complex protein complex involved in cell adhesion integrin alpha5-beta1 complex neuromuscular junction synapse cell junction membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane cell-cell junction intercalated disc anchoring junction cell-cell contact zone integrin alpha9-beta1 complex integrin alpha6-beta1 complex focal adhesion cell-substrate junction integrin alpha4-beta1 complex plasma membrane region synaptic membrane ruffle cell leading edge leading edge membrane ruffle membrane cell projection membrane cell surface membrane microdomain membrane raft cell division site cleavage furrow integrin alphav-beta1 complex integrin alpha7-beta1 complex Schaffer collateral - CA1 synapse integrin alpha2-beta1 complex lamellipodium external side of plasma membrane side of membrane myelin sheath abaxonal region myelin sheath extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle sarcolemma perinuclear region of cytoplasm integrin alpha10-beta1 complex cerebellar climbing fiber to Purkinje cell synapse neuron to neuron synapse asymmetric synapse glutamatergic synapse excitatory synapse asymmetric, glutamatergic, excitatory synapse actin-based cell projection filopodium pigment granule melanosome glial cell projection integrin alpha11-beta1 complex integrin alpha8-beta1 complex integrin alpha3-beta1 complex
C	TS2/16 VH(S112C)-SARAH	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3T3 kinase activity enzyme regulator activity protein serine/threonine kinase activator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity molecular function regulator activity protein kinase activator activity kinase regulator activity histone H2BS14 kinase activity histone H2B kinase activity identical protein binding protein binding histone H3S57 kinase activity Rho-dependent protein serine/threonine kinase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity cation binding magnesium ion binding metal ion binding protein homodimerization activity protein dimerization activity histone H3T11 kinase activity histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development positive regulation of locomotion regulation of cellular process regulation of cell motility regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development positive regulation of locomotion regulation of cellular process regulation of cell motility regulation of substrate-dependent cell migration, cell attachment to substrate positive regulation of biological process positive regulation of cell migration cell adhesion positive regulation of cell-substrate adhesion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process regulation of biological process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion regulation of locomotion substrate-dependent cell migration substrate-dependent cell migration, cell attachment to substrate cellular process positive regulation of substrate-dependent cell migration, cell attachment to substrate cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly cellular component organization or biogenesis apoptotic process cell death programmed cell death negative regulation of signaling regulation of canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth regulation of multicellular organismal process negative regulation of multicellular organismal process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process cellular developmental process primitive hemopoiesis hemopoiesis animal organ development cell development embryo development embryonic hemopoiesis cell differentiation embryonic organ development protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport embryonic epithelial tube formation chordate embryonic development tube formation epithelial tube formation tube morphogenesis embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway apoptotic signaling pathway protein autophosphorylation branching morphogenesis of an epithelial tube angiogenesis blood vessel development blood vessel morphogenesis vasculature development circulatory system development branching involved in blood vessel morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium cell morphogenesis fat cell differentiation positive regulation of fat cell differentiation regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of fat cell differentiation negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation epidermal cell differentiation epidermis development epithelial cell differentiation skin development keratinocyte differentiation positive regulation of epithelial cell apoptotic process regulation of epithelial cell apoptotic process positive regulation of hepatocyte apoptotic process epithelial cell apoptotic process regulation of hepatocyte apoptotic process hepatocyte apoptotic process hippo signaling positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of hippo signaling regulation of hippo signaling positive regulation of signaling heart development endocardium development positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of apoptotic signaling pathway cell differentiation involved in embryonic placenta development placenta development reproductive process developmental process involved in reproduction in utero embryonic development embryonic placenta development regulation of cell differentiation involved in embryonic placenta development regulation of reproductive process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex nuclear body
D	TS2/16 VL-SARAH(S37C)	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding histone H3T6 kinase activity histone H3T3 kinase activity enzyme regulator activity protein serine/threonine kinase activator activity molecular function activator activity protein kinase regulator activity kinase activator activity enzyme activator activity molecular function regulator activity protein kinase activator activity kinase regulator activity histone H2BS14 kinase activity histone H2B kinase activity identical protein binding protein binding histone H3S57 kinase activity Rho-dependent protein serine/threonine kinase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity cation binding magnesium ion binding metal ion binding protein homodimerization activity protein dimerization activity histone H3T11 kinase activity histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development positive regulation of locomotion regulation of cellular process regulation of cell motility regulation of protein stability biological regulation regulation of biological quality protein stabilization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development positive regulation of locomotion regulation of cellular process regulation of cell motility regulation of substrate-dependent cell migration, cell attachment to substrate positive regulation of biological process positive regulation of cell migration cell adhesion positive regulation of cell-substrate adhesion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process regulation of biological process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion regulation of locomotion substrate-dependent cell migration substrate-dependent cell migration, cell attachment to substrate cellular process positive regulation of substrate-dependent cell migration, cell attachment to substrate cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein tetramerization protein-containing complex assembly cellular component organization or biogenesis apoptotic process cell death programmed cell death negative regulation of signaling regulation of canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of growth regulation of developmental growth regulation of developmental process developmental growth negative regulation of developmental process growth organ growth negative regulation of organ growth negative regulation of developmental growth negative regulation of growth regulation of organ growth regulation of multicellular organismal process negative regulation of multicellular organismal process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process cellular developmental process primitive hemopoiesis hemopoiesis animal organ development cell development embryo development embryonic hemopoiesis cell differentiation embryonic organ development protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport embryonic epithelial tube formation chordate embryonic development tube formation epithelial tube formation tube morphogenesis embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway apoptotic signaling pathway protein autophosphorylation branching morphogenesis of an epithelial tube angiogenesis blood vessel development blood vessel morphogenesis vasculature development circulatory system development branching involved in blood vessel morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium cell morphogenesis fat cell differentiation positive regulation of fat cell differentiation regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of fat cell differentiation negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation epidermal cell differentiation epidermis development epithelial cell differentiation skin development keratinocyte differentiation positive regulation of epithelial cell apoptotic process regulation of epithelial cell apoptotic process positive regulation of hepatocyte apoptotic process epithelial cell apoptotic process regulation of hepatocyte apoptotic process hepatocyte apoptotic process hippo signaling positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of hippo signaling regulation of hippo signaling positive regulation of signaling heart development endocardium development positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of apoptotic signaling pathway cell differentiation involved in embryonic placenta development placenta development reproductive process developmental process involved in reproduction in utero embryonic development embryonic placenta development regulation of cell differentiation involved in embryonic placenta development regulation of reproductive process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex nuclear body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013517	FG-GAP repeat	Repeat
A	IPR013519	Integrin alpha beta-propellor	Repeat
A	IPR000413	Integrin alpha chain	Family
A	IPR048286	Integrin alpha, third immunoglobulin-like domain	Domain
A	IPR013649	Integrin alpha, first immunoglubulin-like domain	Domain
A	IPR028994	Integrin alpha, N-terminal	Homologous Superfamily
A	IPR048285	Integrin alpha, second immunoglobulin-like domain	Domain
A	IPR032695	Integrin domain superfamily	Homologous Superfamily
A	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site	Conserved Site
B	IPR033760	Integrin beta N-terminal	Domain
B	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
B	IPR032695	Integrin domain superfamily	Homologous Superfamily
B	IPR002369	Integrin beta subunit, VWA domain	Domain
B	IPR040622	Integrin beta, epidermal growth factor-like domain 1	Domain
B	IPR036349	Integrin beta tail domain superfamily	Homologous Superfamily
B	IPR014836	Integrin beta subunit, cytoplasmic domain	Domain
B	IPR012896	Integrin beta subunit, tail	Domain
B	IPR013111	Epidermal growth factor-like domain, extracellular	Domain
B	IPR015812	Integrin beta subunit	Family
B	IPR016201	PSI domain	Domain
C	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
C	IPR000719	Protein kinase domain	Domain
C	IPR017441	Protein kinase, ATP binding site	Binding Site
C	IPR011524	SARAH domain	Domain
C	IPR024205	Mst1/2 SARAH domain	Domain
C	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase	Family
C	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
D	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
D	IPR000719	Protein kinase domain	Domain
D	IPR017441	Protein kinase, ATP binding site	Binding Site
D	IPR011524	SARAH domain	Domain
D	IPR024205	Mst1/2 SARAH domain	Domain
D	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase	Family
D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P23229	junctional epidermolysis bullosa with pyloric atresia rheumatoid arthritis epidermolysis bullosa malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor breast carcinoma common variable immunodeficiency Duchenne muscular dystrophy glioblastoma juvenile dermatomyositis lung cancer malignant mesothelioma osteosarcoma junctional epidermolysis bullosa with pyloric atresia rheumatoid arthritis epidermolysis bullosa malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor breast carcinoma common variable immunodeficiency Duchenne muscular dystrophy glioblastoma juvenile dermatomyositis lung cancer malignant mesothelioma osteosarcoma prostate cancer tuberculosis Barrett esophagus cancer cystic fibrosis junctional epidermolysis bullosa large cell medulloblastoma lung carcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma prostate carcinoma breast cancer childhood-onset schizophrenia dermatomyositis esophageal adenocarcinoma lung adenocarcinoma
B	Pharos: P05556	dilated cardiomyopathy cardiomyopathy squamous cell carcinoma Liver Cirrhosis, Experimental non-small cell lung carcinoma congestive heart failure endometriosis calcinosis malignant glioma cancer pilocytic astrocytoma subependymal giant cell astrocytoma lung adenocarcinoma malignant pancreatic neoplasm multiple sclerosis dilated cardiomyopathy cardiomyopathy squamous cell carcinoma Liver Cirrhosis, Experimental non-small cell lung carcinoma congestive heart failure endometriosis calcinosis malignant glioma cancer pilocytic astrocytoma subependymal giant cell astrocytoma lung adenocarcinoma malignant pancreatic neoplasm multiple sclerosis atypical teratoid rhabdoid tumor osteosarcoma primitive neuroectodermal tumor Crohn disease dilated cardiomyopathy 1A malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma dermatomyositis Down syndrome glioblastoma heart failure
C	Pharos: Q13043	combined immunodeficiency due to STK4 deficiency pancreatic intraductal papillary-mucinous carcinoma Pancreatic Neuroendocrine Tumor acute myeloid leukemia gastrointestinal stromal tumor large cell medulloblastoma mast cell leukemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis aggressive systemic mastocytosis cutaneous lupus erythematosus idiopathic pulmonary fibrosis interstitial lung disease lung carcinoma combined immunodeficiency due to STK4 deficiency pancreatic intraductal papillary-mucinous carcinoma Pancreatic Neuroendocrine Tumor acute myeloid leukemia gastrointestinal stromal tumor large cell medulloblastoma mast cell leukemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis aggressive systemic mastocytosis cutaneous lupus erythematosus idiopathic pulmonary fibrosis interstitial lung disease lung carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia renal cell carcinoma bipolar disorder endogenous depression interstitial cystitis invasive ductal breast carcinoma malignant pancreatic neoplasm osteosarcoma
D	Pharos: Q13043	combined immunodeficiency due to STK4 deficiency pancreatic intraductal papillary-mucinous carcinoma Pancreatic Neuroendocrine Tumor acute myeloid leukemia gastrointestinal stromal tumor large cell medulloblastoma mast cell leukemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis aggressive systemic mastocytosis cutaneous lupus erythematosus idiopathic pulmonary fibrosis interstitial lung disease lung carcinoma combined immunodeficiency due to STK4 deficiency pancreatic intraductal papillary-mucinous carcinoma Pancreatic Neuroendocrine Tumor acute myeloid leukemia gastrointestinal stromal tumor large cell medulloblastoma mast cell leukemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis aggressive systemic mastocytosis cutaneous lupus erythematosus idiopathic pulmonary fibrosis interstitial lung disease lung carcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia renal cell carcinoma bipolar disorder endogenous depression interstitial cystitis invasive ductal breast carcinoma malignant pancreatic neoplasm osteosarcoma