Annotations: 8R1U

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Mucin-5AC	structural molecule activity extracellular matrix structural constituent cation binding ion binding binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular exosome membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle cellular anatomical structure organelle lumen organelle cytoplasm extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle mucus layer cell periphery plasma membrane membrane extracellular matrix external encapsulating structure

Chains	Accession	Name	Type
A, B	IPR050780	Mucin/von Willebrand/Thrombospondin superfamily	Family
A, B	IPR002919	Trypsin Inhibitor-like, cysteine rich domain	Domain
A, B	IPR001007	VWFC domain	Domain
A, B	IPR001846	von Willebrand factor, type D domain	Domain
A, B	IPR014853	VWF/SSPO/Zonadhesin-like, cysteine-rich domain	Domain
A, B	IPR036084	Serine protease inhibitor-like superfamily	Homologous Superfamily
A, B	IPR025155	WxxW domain	Domain
A, B	IPR006207	Cystine knot, C-terminal	Domain

Chains	Drug Target	Associated Disease
A, B	Pharos: P98088	asthma large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis gastric carcinoma lung cancer medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia idiopathic pulmonary fibrosis malignant glioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous carcinoma asthma large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis gastric carcinoma lung cancer medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia idiopathic pulmonary fibrosis malignant glioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis