8VMF

Crystal structure of a transition-state mimic of the GSK-3/Axin complex bound to a beta-catenin S45D peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8079613	3000066	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Glycogen synthase kinase-3 beta	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups beta-catenin binding tau-protein kinase activity cytoskeletal protein binding tau protein binding p53 binding ionotropic glutamate receptor binding signaling receptor binding glutamate receptor binding protein serine kinase activity cell adhesion molecule binding protein-containing complex binding integrin binding protein serine/threonine kinase binding dynein complex binding	cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality positive regulation of cellular process trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of long-term synaptic potentiation protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport canonical Wnt signaling pathway Wnt signaling pathway cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation regulation of dopaminergic neuron differentiation anatomical structure development negative regulation of cellular process negative regulation of dopaminergic neuron differentiation negative regulation of cell differentiation system development developmental process dopaminergic neuron differentiation negative regulation of developmental process nervous system development generation of neurons negative regulation of neuron differentiation regulation of neuron differentiation extrinsic apoptotic signaling pathway via death domain receptors negative regulation of signaling regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway via death domain receptors apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis axon extension positive regulation of nervous system development axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron projection morphogenesis positive regulation of cell projection organization positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis positive regulation of multicellular organismal process regulation of neuron projection development positive regulation of cellular component organization plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis regulation of axon extension regulation of nervous system development regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis positive regulation of axon extension positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth positive regulation of cell growth axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process regulation of protein metabolic process primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process metabolic process ubiquitin-dependent protein catabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process regulation of localization regulation of protein localization regulation of protein export from nucleus regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of nucleocytoplasmic transport regulation of protein transport regulation of cellular localization regulation of intracellular protein transport muscle structure development striated muscle cell differentiation muscle cell differentiation myotube differentiation protein localization to microtubule cytoskeleton regulation of protein localization to centrosome protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to organelle negative regulation of protein localization to centrosome protein localization to centrosome negative regulation of protein localization cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation regulation of glycogen biosynthetic process negative regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process negative regulation of carbohydrate metabolic process negative regulation of glycogen metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process glycogen metabolic process negative regulation of metabolic process generation of precursor metabolites and energy glycogen biosynthetic process macromolecule biosynthetic process biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process negative regulation of macromolecule biosynthetic process energy reserve metabolic process regulation of macromolecule biosynthetic process regulation of carbohydrate biosynthetic process regulation of glycogen metabolic process response to metal ion response to chemical response to zinc ion protein localization to microtubule protein phosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process fat cell differentiation regulation of epithelial to mesenchymal transition mesenchyme development animal organ development tissue development negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of multicellular organismal process regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation response to biotic stimulus intracellular signal transduction cellular response to biotic stimulus ER overload response cellular response to stress response to stress ER-nucleus signaling pathway response to endoplasmic reticulum stress regulation of leukocyte proliferation osteoclast proliferation regulation of osteoclast proliferation positive regulation of osteoclast proliferation leukocyte proliferation positive regulation of leukocyte proliferation calcineurin-NFAT signaling cascade negative regulation of intracellular signal transduction negative regulation of calcineurin-NFAT signaling cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of calcineurin-mediated signaling regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade negative regulation of calcium-mediated signaling calcium-mediated signaling negative regulation of calcineurin-mediated signaling calcineurin-mediated signaling positive regulation of autophagy autophagy regulation of autophagy process utilizing autophagic mechanism regulation of osteoblast differentiation osteoblast differentiation ossification rhythmic process circadian rhythm regulation of circadian rhythm positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation regulation of peptidyl-threonine phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification peptidyl-threonine modification positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-threonine phosphorylation regulation of phosphorus metabolic process regulation of phosphorylation peptidyl-threonine phosphorylation regulation of mitochondrial membrane potential positive regulation of mitochondrial membrane potential positive regulation of membrane potential regulation of dendrite morphogenesis negative regulation of cellular component organization regulation of dendrite development negative regulation of neurogenesis dendrite development negative regulation of nervous system development negative regulation of cell projection organization negative regulation of dendrite morphogenesis dendrite morphogenesis negative regulation of cell development protein localization to synapse regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation striated muscle tissue development positive regulation of cardiocyte differentiation positive regulation of striated muscle cell differentiation muscle tissue development positive regulation of cardiac muscle cell differentiation heart development cardiac muscle tissue development cardiac muscle cell differentiation positive regulation of muscle cell differentiation cardiocyte differentiation circulatory system development regulation of muscle cell differentiation regulation of cardiocyte differentiation sexual reproduction reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation chromatin organization chromatin remodeling epigenetic programming of gene expression epigenetic regulation of gene expression multicellular organismal reproductive process gene expression genomic imprinting regulation of gene expression autosome genomic imprinting germ cell development response to mechanical stimulus response to external stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus hepatocyte apoptotic process epithelial cell apoptotic process cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to insulin cellular response to insulin stimulus positive regulation of organelle organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cilium organization organelle assembly positive regulation of cellular component biogenesis regulation of cell projection assembly regulation of cellular component biogenesis regulation of organelle organization regulation of plasma membrane bounded cell projection assembly positive regulation of cilium assembly organelle organization regulation of cilium assembly regulation of organelle assembly cell projection assembly positive regulation of plasma membrane bounded cell projection assembly positive regulation of organelle assembly regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus negative regulation of locomotion regulation of cell motility negative regulation of neuron migration regulation of neuron migration regulation of cell migration cell migration cell motility locomotion negative regulation of cell migration neuron migration regulation of locomotion negative regulation of cell motility positive regulation of neuromuscular junction development neuromuscular junction development regulation of synaptic assembly at neuromuscular junction regulation of synapse structure or activity synapse organization regulation of neuromuscular junction development positive regulation of synaptic assembly at neuromuscular junction regulation of cell junction assembly synapse assembly positive regulation of synapse assembly cell junction assembly regulation of synapse assembly regulation of synapse organization positive regulation of cell junction assembly cell junction organization synaptic assembly at neuromuscular junction apoptotic mitochondrial changes mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrial membrane permeability mitochondrial transport mitochondrion organization membrane organization positive regulation of transport regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrion organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process mitochondrial outer membrane permeabilization cellular response to amyloid-beta response to amyloid-beta muscle cell apoptotic process smooth muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process negative regulation of muscle cell apoptotic process protein acylation negative regulation of protein modification process negative regulation of protein metabolic process negative regulation of protein acetylation regulation of protein acetylation protein acetylation positive regulation of macromolecule biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of programmed cell death positive regulation of apoptotic process neuron apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process negative regulation of neuron projection development negative regulation of dendrite development establishment of cell polarity establishment or maintenance of cell polarity fibroblast activation cell activation hepatic stellate cell activation regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway negative regulation of cellular response to insulin stimulus negative regulation of insulin receptor signaling pathway signal transduction in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand cytoskeleton organization response to peptide cellular response to interleukin-3 response to cytokine cellular response to cytokine stimulus response to interleukin-3 regulation of neuronal synaptic plasticity negative regulation of TOR signaling TOR signaling regulation of TOR signaling myoblast fusion cell-cell fusion syncytium formation by plasma membrane fusion anatomical structure formation involved in morphogenesis syncytium formation peptidyl-serine modification peptidyl-serine phosphorylation cardiac muscle cell development organ growth striated muscle cell development muscle cell development cardiac muscle hypertrophy cardiac cell development cardiac muscle tissue growth muscle hypertrophy heart growth physiological muscle hypertrophy striated muscle hypertrophy muscle system process cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy cell cycle re-entry into mitotic cell cycle cell cycle process regulation of muscle adaptation negative regulation of muscle hypertrophy regulation of muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy muscle adaptation negative regulation of cardiac muscle hypertrophy positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of modification of synaptic structure regulation of modification of postsynaptic structure modification of synaptic structure modification of postsynaptic structure tissue remodeling bone remodeling protein localization to cilium positive regulation of protein localization to cilium regulation of protein localization to cilium positive regulation of protein localization animal organ morphogenesis phosphatidylinositol 3-kinase/protein kinase B signal transduction meiotic cell cycle organelle fission meiotic cell cycle process nuclear division meiosis I meiosis I cell cycle process meiotic nuclear division regulation of neuron maturation negative regulation of neuron maturation cell maturation regulation of cell maturation developmental maturation anatomical structure maturation neuron maturation negative regulation of cell maturation neuron projection organization regulation of cytoskeleton organization microtubule cytoskeleton organization regulation of microtubule-based process microtubule-based process regulation of microtubule cytoskeleton organization positive regulation of nucleocytoplasmic transport positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport positive regulation of protein export from nucleus positive regulation of intracellular protein transport positive regulation of stem cell differentiation stem cell differentiation regulation of stem cell differentiation maintenance of cell polarity intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway regulation of DNA biosynthetic process positive regulation of DNA biosynthetic process DNA metabolic process positive regulation of DNA metabolic process DNA biosynthetic process regulation of DNA metabolic process response to hepatocyte growth factor cellular response to growth factor stimulus cellular response to hepatocyte growth factor stimulus response to growth factor response to lipid response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to steroid hormone cellular response to lipid cellular response to steroid hormone stimulus response to organic cyclic compound negative regulation of cell junction assembly negative regulation of growth negative regulation of synaptic assembly at neuromuscular junction negative regulation of developmental growth negative regulation of neuromuscular junction development negative regulation of synapse organization negative regulation of synapse assembly myeloid leukocyte differentiation regulation of leukocyte differentiation positive regulation of osteoclast differentiation regulation of osteoclast differentiation positive regulation of hemopoiesis osteoclast differentiation regulation of immune system process positive regulation of immune system process hemopoiesis regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation leukocyte differentiation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cell junction dendrite cellular anatomical structure intracellular anatomical structure cytoplasm cytosol neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cell junction dendrite dendritic tree cell periphery plasma membrane membrane protein-containing complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex Schaffer collateral - CA1 synapse ribonucleoprotein complex membrane-bounded organelle organelle glutamatergic synapse dendritic shaft perinuclear region of cytoplasm cell body neuronal cell body axon polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton mitochondrion intracellular membrane-bounded organelle growth cone distal axon site of polarized growth nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Wnt signalosome postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse spindle meiotic spindle
C	Catenin beta-1	protein binding binding alpha-catenin binding protein phosphatase binding phosphatase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding signaling receptor binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding protein binding binding alpha-catenin binding protein phosphatase binding phosphatase binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding signaling receptor binding kinase binding protein kinase binding SMAD binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cell adhesion molecule binding cadherin binding histone methyltransferase binding transcription coregulator binding transcription corepressor binding nuclear estrogen receptor binding I-SMAD binding chromatin binding transmembrane transporter binding disordered domain specific binding protein domain specific binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development oviduct development reproductive system development reproductive process developmental process involved in reproduction reproductive structure development dorsal/ventral pattern formation dorsal/ventral axis specification pattern specification process axis specification regionalization regulation of cellular process cellular developmental process cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development neurogenesis cell differentiation cellular process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cell population proliferation regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation smooth muscle cell proliferation embryonic skeletal joint development limb development chordate embryonic development embryonic limb morphogenesis embryonic appendage morphogenesis embryo development embryonic skeletal joint morphogenesis embryo development ending in birth or egg hatching skeletal system development animal organ morphogenesis embryonic organ development embryonic skeletal system morphogenesis embryonic organ morphogenesis embryonic skeletal limb joint morphogenesis appendage development embryonic morphogenesis animal organ development appendage morphogenesis limb joint morphogenesis embryonic skeletal system development skeletal system morphogenesis limb morphogenesis heart morphogenesis cardioblast proliferation regulation of cardioblast proliferation animal organ formation regulation of secondary heart field cardioblast proliferation heart development heart formation cell proliferation involved in heart morphogenesis regulation of cell proliferation involved in heart morphogenesis response to fibroblast growth factor positive regulation of cell communication cellular response to growth factor stimulus positive regulation of signal transduction positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling response to endogenous stimulus regulation of cellular response to growth factor stimulus regulation of response to stimulus fibroblast growth factor receptor signaling pathway regulation of cell communication response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway positive regulation of signaling regulation of timing of anagen epidermis development molting cycle process anagen hair cycle phase skin epidermis development hair follicle development hair follicle maturation regulation of hair follicle maturation epithelium development biological phase hair cycle developmental maturation tissue development skin development anatomical structure maturation molting cycle hair cycle process maintenance of cell number stem cell population maintenance prostate gland development gland development epithelial cell proliferation involved in prostate gland development urogenital system development epithelial cell proliferation trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission detection of external stimulus detection of stimulus detection of mechanical stimulus detection of muscle stretch response to mechanical stimulus response to external stimulus response to abiotic stimulus detection of abiotic stimulus response to muscle stretch adherens junction organization adherens junction assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular component organization or biogenesis cell-cell junction organization cell-cell junction assembly negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of gliogenesis negative regulation of neurogenesis gliogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process regulation of glial cell differentiation negative regulation of gliogenesis negative regulation of cell development negative regulation of oligodendrocyte differentiation negative regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation negative regulation of multicellular organismal process regulation of oligodendrocyte differentiation positive regulation of proteoglycan biosynthetic process proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process positive regulation of sulfur metabolic process positive regulation of glycoprotein metabolic process positive regulation of protein metabolic process carbohydrate derivative metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of sulfur metabolic process positive regulation of biosynthetic process sulfur compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process regulation of glycoprotein biosynthetic process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process positive regulation of heparan sulfate proteoglycan biosynthetic process regulation of protein metabolic process regulation of heparan sulfate proteoglycan biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process regulation of glycoprotein metabolic process sulfur compound biosynthetic process proteoglycan metabolic process epidermal cell differentiation epithelial cell differentiation hair cell differentiation generation of neurons neuron differentiation negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death protein localization localization cellular localization protein localization to cell surface cellular macromolecule localization macromolecule localization sexual reproduction multicellular organismal reproductive process oogenesis cellular process involved in reproduction in multicellular organism female gamete generation gamete generation oocyte development germ cell development oocyte differentiation developmental growth cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell growth cell morphogenesis cell projection morphogenesis neuron projection morphogenesis neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth developmental growth involved in morphogenesis neuron development branching morphogenesis of an epithelial tube respiratory tube development lung morphogenesis lung development respiratory system development epithelial tube morphogenesis morphogenesis of an epithelium tissue morphogenesis morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium sympathetic nervous system development ganglion development autonomic nervous system development sympathetic ganglion development positive regulation of mesenchymal cell proliferation positive regulation of cell population proliferation regulation of mesenchymal cell proliferation mesenchymal cell proliferation synapse organization vesicle localization transport synaptic vesicle clustering synaptic vesicle cycle establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse organelle localization establishment of localization in cell synaptic vesicle localization cell maturation anterior/posterior axis specification anterior/posterior pattern specification positive regulation of odontoblast differentiation regulation of epithelial cell differentiation positive regulation of developmental process positive regulation of cell differentiation neuroepithelial cell differentiation odontoblast differentiation regulation of odontoblast differentiation positive regulation of epithelial cell differentiation columnar/cuboidal epithelial cell differentiation positive regulation of neuroepithelial cell differentiation apoptotic signaling pathway myeloid leukocyte differentiation hemopoiesis myeloid cell differentiation osteoclast differentiation leukocyte differentiation camera-type eye morphogenesis sensory organ development eye development visual system development eye morphogenesis lens morphogenesis in camera-type eye sensory organ morphogenesis camera-type eye development sensory system development lens development in camera-type eye negative regulation of blood vessel morphogenesis negative regulation of angiogenesis negative regulation of vasculature development negative regulation of post-translational protein modification regulation of protein sumoylation regulation of protein modification process peptidyl-lysine modification peptidyl-amino acid modification negative regulation of protein modification process protein modification process regulation of protein modification by small protein conjugation or removal negative regulation of protein sumoylation negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification protein sumoylation macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal outflow tract morphogenesis cell fate specification cell fate commitment forebrain development glial cell migration telencephalon glial cell migration cerebral cortex development telencephalon cell migration forebrain cell migration cell migration cell motility layer formation in cerebral cortex cerebral cortex cell migration head development brain development cerebral cortex radially oriented cell migration pallium development cerebral cortex radial glia-guided migration telencephalon development hindbrain development positive regulation of gene expression regulation of stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation in utero embryonic development intracellular signal transduction intracellular signaling cassette MAPK cascade cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation immune system process T cell differentiation neuron fate commitment cell fate determination neuron fate determination positive regulation of determination of dorsal identity regulation of determination of dorsal identity determination of bilateral symmetry determination of dorsal/ventral asymmetry positive regulation of multicellular organismal process determination of dorsal identity specification of symmetry intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process negative regulation of signaling negative regulation of intracellular signal transduction regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of response to stimulus negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of signal transduction neuron intrinsic apoptotic signaling pathway in response to oxidative stress negative regulation of intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of neuron apoptotic process regulation of apoptotic signaling pathway canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation stem cell differentiation mesenchymal stem cell differentiation mesonephric epithelium development kidney epithelium development nephron morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development ureteric bud morphogenesis branching involved in ureteric bud morphogenesis renal tubule development nephron development nephron epithelium development ureteric bud development mesonephros development kidney morphogenesis mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis microtubule organizing center organization regulation of cell cycle process microtubule cytoskeleton organization centriole-centriole cohesion organelle organization centrosome cycle microtubule-based process cell cycle regulation of cell cycle regulation of centriole-centriole cohesion cytoskeleton organization cell cycle process multicellular organismal-level homeostasis homeostatic process tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption ossification osteoblast differentiation immune system development hematopoietic or lymphoid organ development thymus development transcription by RNA polymerase II cranial ganglion development nerve development cranial nerve development foregut regionalization developmental induction regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis specification of animal organ identity regulation of branching involved in lung morphogenesis regulation of morphogenesis of an epithelium morphogenesis of an epithelial bud morphogenesis of an epithelial fold morphogenesis of embryonic epithelium regulation of embryonic development lung field specification lung induction primary lung bud formation positive regulation of animal organ morphogenesis regulation of animal organ formation organ induction glial cell fate determination glial cell fate commitment pancreas development positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade embryonic axis specification embryonic pattern specification positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process dopaminergic neuron differentiation central nervous system neuron differentiation midbrain development midbrain dopaminergic neuron differentiation neuron migration transcription elongation by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of DNA-templated transcription, elongation regulation of transcription by RNA polymerase II regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II positive regulation of transcription by RNA polymerase II DNA-templated transcription elongation response to chemical response to xenobiotic stimulus epithelial cell differentiation involved in prostate gland development digestive system development foregut morphogenesis digestive tract development embryonic foregut morphogenesis digestive tract morphogenesis myoblast proliferation astrocyte-dopaminergic neuron signaling glial cell-neuron signaling regulation of epithelial cell differentiation involved in kidney development regulation of nephron tubule epithelial cell differentiation epithelial cell differentiation involved in kidney development nephron tubule epithelial cell differentiation cell differentiation involved in kidney development establishment of organelle localization establishment of vesicle localization synaptic vesicle transport dorsal root ganglion development genitalia development sex differentiation male sex differentiation male genitalia development endothelium development morphogenesis of an endothelium endothelial tube morphogenesis epidermis morphogenesis hair follicle morphogenesis embryonic hindlimb morphogenesis hindlimb morphogenesis mesenchymal cell proliferation involved in lung development branching involved in blood vessel morphogenesis positive regulation of myoblast proliferation regulation of myoblast proliferation metanephros development metanephros morphogenesis positive regulation of organelle organization telomere organization regulation of DNA biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of telomere maintenance via telomere lengthening positive regulation of telomere maintenance DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization telomere maintenance via telomerase chromosome organization positive regulation of DNA biosynthetic process regulation of telomere maintenance via telomerase positive regulation of endothelial cell differentiation endothelial cell differentiation regulation of endothelial cell differentiation regulation of synapse structure or activity regulation of synapse assembly regulation of biological quality regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization synapse assembly connective tissue development chondrocyte differentiation cartilage development negative regulation of transcription by RNA polymerase II formation of primary germ layer gastrulation cell fate commitment involved in formation of primary germ layer endoderm development endoderm formation endodermal cell fate commitment endodermal cell differentiation gastrulation with mouth forming second regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development epithelial to mesenchymal transition mesenchymal cell differentiation regulation of localization regulation of protein localization regulation of cellular localization regulation of protein localization to cell surface renal vesicle morphogenesis regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of epithelial cell differentiation involved in kidney development metanephric renal vesicle morphogenesis renal vesicle development negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis metanephric nephron development mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of epithelial cell differentiation mesenchymal to epithelial transition metanephric nephron morphogenesis cell differentiation involved in metanephros development hypothalamus development diencephalon development limbic system development regulation of reproductive process regulation of epithelial cell proliferation involved in prostate gland development positive regulation of reproductive process positive regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation involved in prostate gland development regulation of epithelial cell proliferation regulation of mitotic cell cycle, embryonic negative regulation of cell cycle mitotic cell cycle negative regulation of mitotic cell cycle mitotic cell cycle, embryonic regulation of mitotic cell cycle negative regulation of mitotic cell cycle, embryonic catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process fibroblast proliferation regulation of fibroblast proliferation establishment of blood-retinal barrier acinar cell differentiation glandular epithelial cell differentiation muscle structure development smooth muscle cell differentiation muscle cell differentiation regulation of protein ubiquitination protein ubiquitination regulation of cartilage development regulation of chondrocyte differentiation negative regulation of cartilage development negative regulation of chondrocyte differentiation negative regulation of gene expression proximal/distal pattern formation response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound embryonic digit morphogenesis ectoderm development regulation of muscle tissue development skeletal muscle tissue development positive regulation of skeletal muscle tissue development regulation of skeletal muscle tissue development striated muscle tissue development skeletal muscle organ development positive regulation of muscle organ development muscle tissue development muscle organ development positive regulation of striated muscle tissue development regulation of striated muscle tissue development positive regulation of muscle tissue development regulation of muscle organ development neuroblast proliferation neural precursor cell proliferation embryonic forelimb morphogenesis forelimb morphogenesis regulation of calcium ion import regulation of calcium ion transport regulation of transport regulation of monoatomic ion transport calcium ion transport metal ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport regulation of leukocyte activation regulation of cell activation leukocyte proliferation lymphocyte proliferation regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of T cell activation regulation of T cell proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process regulation of leukocyte differentiation regulation of osteoclast differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of immune system process regulation of hemopoiesis embryonic brain development protein polyubiquitination central nervous system vasculogenesis vasculogenesis genitalia morphogenesis sister chromatid cohesion centromeric sister chromatid cohesion regulation of centromeric sister chromatid cohesion regulation of sister chromatid cohesion cell adhesion lung epithelium development lung epithelial cell differentiation lung cell differentiation positive regulation of morphogenesis of an epithelium positive regulation of branching involved in lung morphogenesis neural plate development cell-matrix adhesion cell-substrate adhesion ectodermal placode morphogenesis hair follicle placode formation ectodermal placode formation ectodermal placode development regulation of myelination myelination axon ensheathment ensheathment of neurons establishment of blood-brain barrier lung-associated mesenchyme development odontogenesis of dentin-containing tooth odontogenesis cranial skeletal system development embryonic epithelial tube formation tube formation epithelial tube formation nephron tubule formation renal vesicle formation embryonic heart tube development trachea morphogenesis trachea formation trachea development negative regulation of cell population proliferation regulation of osteoblast differentiation positive regulation of osteoblast differentiation renal inner medulla development cellular response to nitrogen compound response to alcohol cellular response to organic cyclic compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to indole-3-methanol cellular response to indole-3-methanol cell-cell adhesion renal outer medulla development positive regulation of nervous system development regulation of neuroblast proliferation positive regulation of neurogenesis regulation of neural precursor cell proliferation positive regulation of cell development positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation tongue development fungiform papilla formation fungiform papilla development fungiform papilla morphogenesis tongue morphogenesis	membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola membrane microdomain cell periphery cellular anatomical structure flotillin complex plasma membrane region cell-cell junction membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola membrane microdomain cell periphery cellular anatomical structure flotillin complex plasma membrane region cell-cell junction intercalated disc anchoring junction cell junction fascia adherens cell-cell contact zone focal adhesion cell-substrate junction membrane-bounded organelle RNA polymerase II transcription regulator complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle beta-catenin-TCF7L2 complex intracellular organelle catenin-TCF7L2 complex organelle beta-catenin-TCF complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex Schaffer collateral - CA1 synapse synapse euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome cell projection cell leading edge plasma membrane bounded cell projection lamellipodium postsynapse postsynaptic membrane synaptic membrane cytoskeleton spindle spindle pole microtubule cytoskeleton Z disc sarcomere I band contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex apical part of cell extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle actin-based cell projection microvillus microvillus membrane cell projection membrane presynapse presynaptic membrane cell cortex cytoplasmic region presynaptic active zone cytoplasmic component cell cortex region presynaptic active zone extrinsic component of plasma membrane catenin complex extrinsic component of membrane Scrib-APC-beta-catenin complex glutamatergic synapse RNA polymerase II transcription repressor complex beta-catenin-ICAT complex transcription repressor complex adherens junction centrosome microtubule organizing center membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex cytosol lateral plasma membrane basal part of cell basal plasma membrane basolateral plasma membrane perinuclear region of cytoplasm postsynaptic density, intracellular component postsynaptic specialization postsynaptic specialization, intracellular component postsynaptic density neuron to neuron synapse asymmetric synapse apicolateral plasma membrane Wnt signalosome apical junction complex bicellular tight junction tight junction
B	Axin-1	SMAD binding protein binding binding R-SMAD binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity I-SMAD binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding identical protein binding p53 binding SMAD binding protein binding binding R-SMAD binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity I-SMAD binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding identical protein binding p53 binding signaling adaptor activity armadillo repeat domain binding protein domain specific binding protein homodimerization activity protein dimerization activity kinase binding protein kinase binding beta-catenin binding	developmental process multicellular organism development multicellular organismal process dorsal/ventral pattern formation dorsal/ventral axis specification anatomical structure development pattern specification process axis specification regionalization cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus developmental process multicellular organism development multicellular organismal process dorsal/ventral pattern formation dorsal/ventral axis specification anatomical structure development pattern specification process axis specification regionalization cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization apoptotic process cell death programmed cell death negative regulation of signaling regulation of canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication transcription elongation by RNA polymerase II RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of transcription elongation by RNA polymerase II negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of DNA-templated transcription, elongation regulation of gene expression DNA-templated transcription elongation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular developmental process cell differentiation cell development positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of proteasomal protein catabolic process catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process regulation of catalytic activity regulation of transferase activity positive regulation of molecular function positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development anatomical structure morphogenesis post-anal tail morphogenesis negative regulation of protein metabolic process positive regulation of cell communication positive regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade positive regulation of signaling protein polyubiquitination protein ubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal epigenetic programming of gene expression epigenetic programming in the zygotic pronuclei epigenetic regulation of gene expression cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus fat cell differentiation regulation of developmental process negative regulation of developmental process regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of cell differentiation regulation of fat cell differentiation cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway formation of primary germ layer mesoderm morphogenesis embryonic morphogenesis tissue development gastrulation axial mesoderm development tissue morphogenesis axial mesoderm formation anatomical structure formation involved in morphogenesis axial mesoderm morphogenesis mesoderm formation mesoderm development head development regulation of peptidyl-threonine phosphorylation peptidyl-threonine modification positive regulation of peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization supramolecular fiber organization cytoskeleton organization negative regulation of gene expression	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen cell periphery cell cortex plasma membrane membrane protein-containing complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex cytoskeleton microtubule cytoskeleton Wnt signalosome cytoplasmic vesicle intracellular vesicle vesicle lateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000719	Protein kinase domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR050591	Glycogen Synthase Kinase-3	Family
A	IPR039192	Glycogen synthase kinase 3, catalytic domain	Domain
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C	IPR016024	Armadillo-type fold	Homologous Superfamily
C	IPR000225	Armadillo	Repeat
C	IPR011989	Armadillo-like helical	Homologous Superfamily
C	IPR013284	Beta-catenin	Family
B	IPR016137	RGS domain	Domain
B	IPR036305	RGS domain superfamily	Homologous Superfamily
B	IPR032101	Axin-1/2, tankyrase-binding domain	Domain
B	IPR044926	RGS, subdomain 2	Homologous Superfamily
B	IPR038207	DIX domain superfamily	Homologous Superfamily
B	IPR024066	RGS, subdomain 1/3	Homologous Superfamily
B	IPR043581	Axin-like	Family
B	IPR014936	Axin beta-catenin binding	Domain
B	IPR001158	DIX domain	Domain
B	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: P35222	medulloblastoma pilomatrixoma ovarian cancer kidney Wilms tumor severe intellectual disability-progressive spastic diplegia syndrome colorectal cancer hepatoblastoma adrenal cortex carcinoma craniopharyngioma hepatocellular adenoma angiosarcoma muscular atrophy adenoma Stevens-Johnson syndrome desmoid tumor medulloblastoma pilomatrixoma ovarian cancer kidney Wilms tumor severe intellectual disability-progressive spastic diplegia syndrome colorectal cancer hepatoblastoma adrenal cortex carcinoma craniopharyngioma hepatocellular adenoma angiosarcoma muscular atrophy adenoma Stevens-Johnson syndrome desmoid tumor breast cancer cirrhosis of liver malignant mesothelioma breast carcinoma melanotic medulloblastoma prostate cancer liver cancer cecal neoplasm Aberrant Crypt Foci cervical cancer adenocarcinoma tubular adenocarcinoma papillary adenoma adult medulloblastoma malignant pancreatic neoplasm intellectual disability mantle cell lymphoma medullomyoblastoma with myogenic differentiation microcystic adenoma cecum cancer exudative vitreoretinopathy 7 childhood medulloblastoma follicular thyroid adenoma papillary craniopharyngioma intestinal cancer cancer adamantinous craniopharyngioma malignant colon neoplasm granular cell carcinoma adrenal gland cancer hepatocellular carcinoma parathyroid gland adenoma hereditary Wilms tumor atypical teratoid rhabdoid tumor desmoplastic/nodular medulloblastoma intestinal disease brain disease medulloblastoma with extensive nodularity drug-induced liver injury plasma cell myeloma kidney disease endometrial carcinoma psoriasis liver neoplasm exudative vitreoretinopathy 1 lung benign neoplasm non-small cell lung carcinoma stomach disease lymphatic system disease colon carcinoma gastric carcinoma malignant ependymoma ovarian neoplasm hematologic disease adrenal cortex adenoma uterine disease pancreatic intraductal papillary-mucinous neoplasm cribriform carcinoma cystadenoma peritoneal neoplasm benign colon neoplasm Perlman syndrome intestinal neoplasm breast disease endometriosis prostate disease esophageal squamous cell carcinoma lung disease osteoporosis toxic epidermal necrolysis colonic neoplasm ovarian carcinoma glioblastoma urinary bladder disease colorectal carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cribriform carcinoma of breast melanoma Emery-Dreifuss muscular dystrophy primitive neuroectodermal tumor large cell medulloblastoma endometrium carcinoma in situ liver disease schizophrenia lung adenocarcinoma osteosarcoma gastric adenocarcinoma tuberculosis colorectal adenocarcinoma ovarian disease adrenal carcinoma pancreatic intraductal papillary-mucinous carcinoma vertebral column disease pancreatic neoplasm adult hepatocellular carcinoma cutaneous melanoma
B	Pharos: O15169	caudal duplication hepatocellular carcinoma cancer adult hepatocellular carcinoma endometrium carcinoma in situ liver cancer medulloblastoma prostate adenocarcinoma atypical teratoid rhabdoid tumor colorectal adenocarcinoma hepatoblastoma Hodgkins lymphoma Liver carcinoma osteoporosis psoriasis caudal duplication hepatocellular carcinoma cancer adult hepatocellular carcinoma endometrium carcinoma in situ liver cancer medulloblastoma prostate adenocarcinoma atypical teratoid rhabdoid tumor colorectal adenocarcinoma hepatoblastoma Hodgkins lymphoma Liver carcinoma osteoporosis psoriasis endometrial carcinoma intestinal disease osteosarcoma