Annotations: 8VYJ

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08016	Polycystin cation channel (PKD_channel)	Polycystin cation channel	-	Family
A	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sodium channel protein type 5 subunit alpha	monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity voltage-gated sodium channel activity involved in AV node cell action potential monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity monoatomic cation transmembrane transporter activity voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity monoatomic ion channel activity sodium channel activity sodium ion transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity voltage-gated sodium channel activity involved in AV node cell action potential monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding ankyrin binding protein binding binding fibroblast growth factor binding growth factor binding calmodulin binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding nitric-oxide synthase binding voltage-gated sodium channel activity involved in bundle of His cell action potential protein domain specific binding voltage-gated sodium channel activity involved in SA node cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential scaffold protein binding transmembrane transporter binding kinase binding protein kinase binding	membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling membrane depolarization during action potential membrane depolarization biological regulation membrane depolarization during cardiac muscle cell action potential action potential regulation of biological quality cardiac muscle cell action potential regulation of membrane potential heart process multicellular organismal process system process cardiac muscle cell action potential involved in contraction signaling atrial cardiac muscle cell to AV node cell signaling regulation of heart contraction regulation of system process cell-cell signaling involved in cardiac conduction cardiac muscle contraction striated muscle contraction cell communication circulatory system process actin filament-based process regulation of multicellular organismal process atrial cardiac muscle cell to AV node cell communication cell communication involved in cardiac conduction blood circulation cardiac muscle cell contraction regulation of biological process atrial cardiac muscle cell action potential cell-cell signaling actin filament-based movement muscle contraction muscle system process regulation of blood circulation membrane depolarization during atrial cardiac muscle cell action potential cardiac conduction cellular process actin-mediated cell contraction heart contraction regulation of heart rate developmental process anatomical structure development brainstem development AV node cell to bundle of His cell communication regulation of cellular process regulation of membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization bundle of His cell to Purkinje myocyte signaling bundle of His cell to Purkinje myocyte communication bundle of His cell action potential regulation of atrial cardiac muscle cell membrane depolarization cardiac muscle cell membrane repolarization membrane repolarization regulation of membrane repolarization ventricular cardiac muscle cell membrane repolarization regulation of cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization AV node cell action potential AV node cell to bundle of His cell signaling head development animal organ development brain development nervous system development multicellular organism development cerebellum development central nervous system development metencephalon development hindbrain development system development cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion Purkinje myocyte to ventricular cardiac muscle cell communication membrane depolarization during Purkinje myocyte cell action potential Purkinje myocyte action potential Purkinje myocyte to ventricular cardiac muscle cell signaling localization transport monoatomic ion transport monoatomic cation transport establishment of localization sodium ion transport metal ion transport regulation of muscle adaptation regulation of muscle system process response to muscle inactivity response to stimulus involved in regulation of muscle adaptation muscle adaptation response to denervation involved in regulation of muscle adaptation regulation of response to stimulus response to muscle inactivity involved in regulation of muscle adaptation response to inactivity regulation of heart rate by cardiac conduction ventricular cardiac muscle cell action potential regulation of actin filament-based process regulation of cardiac muscle contraction regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction membrane depolarization during AV node cell action potential anatomical structure morphogenesis odontogenesis of dentin-containing tooth odontogenesis animal organ morphogenesis SA node cell to atrial cardiac muscle cell signaling SA node cell to atrial cardiac muscle cell communication SA node cell action potential membrane depolarization during SA node cell action potential cell population proliferation positive regulation of cell population proliferation positive regulation of epithelial cell proliferation positive regulation of biological process regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of cellular process monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport heart development cardiac chamber development cardiac ventricle development circulatory system development regulation of action potential positive regulation of action potential regulation of localization regulation of monoatomic ion transmembrane transport regulation of sodium ion transport regulation of sodium ion transmembrane transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport forebrain development telencephalon development atrial cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization cardiac conduction system development cardiac muscle tissue development tissue development striated muscle tissue development muscle tissue development positive regulation of sodium ion transport positive regulation of transport positive regulation of monoatomic ion transport membrane depolarization during bundle of His cell action potential	cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle cell periphery cellular anatomical structure sarcolemma plasma membrane membrane T-tubule intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex perinuclear region of cytoplasm cell-cell junction intercalated disc anchoring junction cell junction cell-cell contact zone membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen organelle lumen nuclear lumen cell surface membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola nucleoplasm protein-containing complex sodium channel complex voltage-gated sodium channel complex plasma membrane protein complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex lateral plasma membrane endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010526	Sodium ion transport-associated domain	Domain
A	IPR043203	Voltage-gated cation channel calcium and sodium	Family
A	IPR008053	Voltage gated sodium channel, alpha-5 subunit	Family
A	IPR024583	Voltage-gated Na+ ion channel, cytoplasmic domain	Domain
A	IPR001696	Voltage gated sodium channel, alpha subunit	Family
A	IPR005821	Ion transport domain	Domain
A	IPR044564	Voltage-gated sodium channel alpha subunit, inactivation gate	Domain
A	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14524	atrial fibrillation Sudden infant death syndrome Brugada syndrome long QT syndrome familial atrial fibrillation long QT syndrome 3 dilated cardiomyopathy 1E progressive familial heart block, type 1A ventricular fibrillation, paroxysmal familial, type 1 atrial fibrillation, familial, 10 ventricular tachycardia dilated cardiomyopathy sick sinus syndrome torsades de pointes sick sinus syndrome 1 atrial fibrillation Sudden infant death syndrome Brugada syndrome long QT syndrome familial atrial fibrillation long QT syndrome 3 dilated cardiomyopathy 1E progressive familial heart block, type 1A ventricular fibrillation, paroxysmal familial, type 1 atrial fibrillation, familial, 10 ventricular tachycardia dilated cardiomyopathy sick sinus syndrome torsades de pointes sick sinus syndrome 1 arrhythmogenic right ventricular cardiomyopathy cardiomyopathy Brugada syndrome 1 psoriasis long QT syndrome 1 scabies epilepsy with generalized tonic-clonic seizures amyotrophic lateral sclerosis familial isolated dilated cardiomyopathy status epilepticus glossopharyngeal neuralgia hemorrhoid Pediculus humanus capitis infestation tinea pedis premature ejaculation trigeminal neuralgia Pthirus pubis infestation Charcot-Marie-Tooth disease malaria epilepsy neuralgia familial long QT syndrome atrial standstill tinea corporis bipolar disorder left ventricular noncompaction urethritis progressive familial heart block familial dilated cardiomyopathy familial sick sinus syndrome paroxysmal familial ventricular fibrillation atrial fibrillation, familial, 1 heart disease partial epilepsy atrial standstill 1 hypertrophic cardiomyopathy postherpetic neuralgia Lennox-Gastaut syndrome

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.