9AW7 | pdb_00009aw7

Yeast 20S proteasome soaked with isolated TMC-95B

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
BA [auth b]	SCOP2B Superfamily	Class II glutamine amidotransferases	8036787	3000131	SCOP2B (2022-06-29)
U [auth N]	SCOP2B Superfamily	Class II glutamine amidotransferases	8036787	3000131	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Class II glutamine amidotransferases	8036842	3000131	SCOP2B (2022-06-29)
N [auth U]	SCOP2B Superfamily	Class II glutamine amidotransferases	8036842	3000131	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
BA [auth b], U [auth N]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
B, I [auth P]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
G, N [auth U]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
G, N [auth U]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, H [auth O]	PRE8 isoform 1	-	-	-
Q [auth J], X	Proteasome subunit beta	-	-	-
R [auth K], Y	proteasome endopeptidase complex	-	-	-
S [auth L], Z	PRE7 isoform 1	-	-	-
AA [auth a], T [auth M]	Proteasome subunit beta	-	-	-
BA [auth b], U [auth N]	Proteasome subunit beta type-1	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process proteolysis metabolic process cellular process protein metabolic process macromolecule metabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process proteolysis metabolic process cellular process protein metabolic process macromolecule metabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex intracellular organelle organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle proteasome storage granule membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B, I [auth P]	PRE9 isoform 1	-	-	-
C, J [auth Q]	PRE6 isoform 1	-	-	-
D, K [auth R]	PUP2 isoform 1	-	-	-
E, L [auth S]	PRE5 isoform 1	-	-	-
F, M [auth T]	PRE10 isoform 1	-	-	-
G, N [auth U]	Proteasome subunit alpha type-1	-	catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process proteolysis metabolic process cellular process protein metabolic process macromolecule metabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process proteolysis metabolic process cellular process protein metabolic process macromolecule metabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome core complex, alpha-subunit complex proteasome core complex nucleus
O [auth H], V	proteasome endopeptidase complex	-	-	-
P [auth I], W	PUP3 isoform 1	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
BA [auth b], U [auth N]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
BA [auth b], U [auth N]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
BA [auth b], U [auth N]	IPR023333	Proteasome B-type subunit	Family
BA [auth b], U [auth N]	IPR001353	Proteasome, subunit alpha/beta	Family
BA [auth b], U [auth N]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
G, N [auth U]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
G, N [auth U]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
G, N [auth U]	IPR050115	Proteasome subunit alpha	Family
G, N [auth U]	IPR023332	Proteasome alpha-type subunit	Family
G, N [auth U]	IPR001353	Proteasome, subunit alpha/beta	Family
G, N [auth U]	IPR034642	Proteasome subunit alpha6	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
G, N [auth U]	CSO	Parent Component: CYS RESID: AA0205 PSI-MOD : L-cysteine sulfenic acid MOD:00210

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.