9BS1 | pdb_00009bs1

Cryo-EM structure of the S. cerevisiae lipid flippase Neo1 bound with PI4P in the E2P state

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16212	Phospholipid-translocating P-type ATPase C-terminal (PhoLip_ATPase_C)	Phospholipid-translocating P-type ATPase C-terminal	-	Family
A	PF00122	E1-E2 ATPase (E1-E2_ATPase)	E1-E2 ATPase	-	Family
A	PF13246	Cation transport ATPase (P-type) (Cation_ATPase)	Cation transport ATPase (P-type)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phospholipid-transporting ATPase NEO1	ATPase-coupled intramembrane lipid transporter activity lipid transporter activity intramembrane lipid transporter activity transporter activity ATP-dependent activity glycerophospholipid flippase activity phosphatidylserine flippase activity aminophospholipid flippase activity flippase activity phospholipid transporter activity cation binding magnesium ion binding ion binding binding ATPase-coupled intramembrane lipid transporter activity lipid transporter activity intramembrane lipid transporter activity transporter activity ATP-dependent activity glycerophospholipid flippase activity phosphatidylserine flippase activity aminophospholipid flippase activity flippase activity phospholipid transporter activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphatidylethanolamine flippase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding lysophosphatidylserine flippase activity phosphatidylserine floppase activity floppase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Golgi vesicle transport cellular component organization organelle organization vacuole organization cellular component organization or biogenesis membrane organization trans-Golgi network membrane organization phospholipid translocation biological regulation lipid localization phospholipid transport lipid transport lipid translocation regulation of membrane lipid distribution regulation of biological quality organophosphate ester transport	cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle trans-Golgi network cell periphery cellular anatomical structure plasma membrane membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle trans-Golgi network cytoplasm endosome intracellular vesicle cytoplasmic vesicle vesicle Golgi membrane bounding membrane of organelle organelle membrane endosome membrane cytoplasmic vesicle membrane vesicle membrane late endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001757	P-type ATPase	Family
A	IPR044492	P-type ATPase, haloacid dehalogenase domain	Domain
A	IPR006539	P-type ATPase, subfamily IV	Family
A	IPR018303	P-type ATPase, phosphorylation site	PTM
A	IPR023298	P-type ATPase, transmembrane domain superfamily	Homologous Superfamily
A	IPR032631	P-type ATPase, N-terminal	Domain
A	IPR023214	HAD superfamily	Homologous Superfamily
A	IPR008250	P-type ATPase, A domain superfamily	Homologous Superfamily
A	IPR036412	HAD-like superfamily	Homologous Superfamily
A	IPR032630	P-type ATPase, C-terminal	Domain
A	IPR023299	P-type ATPase, cytoplasmic domain N	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.