9CP4 | pdb_00009cp4

Cryo-EM structure of human GAT3 in complex with SNAP-5114, inward-open conformation

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sodium- and chloride-dependent GABA transporter 3	transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity monoatomic cation transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity solute:sodium symporter activity amino acid:sodium symporter activity solute:monoatomic cation symporter activity gamma-aminobutyric acid:sodium:chloride symporter activity monoatomic anion:monoatomic cation symporter activity transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity monoatomic cation transmembrane transporter activity monoatomic anion transmembrane transporter activity chloride transmembrane transporter activity solute:sodium symporter activity amino acid:sodium symporter activity solute:monoatomic cation symporter activity gamma-aminobutyric acid:sodium:chloride symporter activity monoatomic anion:monoatomic cation symporter activity secondary active transmembrane transporter activity secondary active monocarboxylate transmembrane transporter activity gamma-aminobutyric acid transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity amino acid:monoatomic cation symporter activity monoatomic anion:sodium symporter activity monocarboxylate:sodium symporter activity sodium ion transmembrane transporter activity sodium:chloride symporter activity chloride:monoatomic cation symporter activity amino acid transmembrane transporter activity organic acid:sodium symporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity metal ion transmembrane transporter activity symporter activity inorganic anion transmembrane transporter activity binding amino acid binding sulfur compound transmembrane transporter activity taurine transmembrane transporter activity taurine:sodium symporter activity	response to stimulus response to chemical response to xenobiotic stimulus import into cell gamma-aminobutyric acid reuptake cellular localization nitrogen compound transport organic anion transport carboxylic acid transport transport amino acid neurotransmitter reuptake neurotransmitter transport establishment of localization organic acid transport response to stimulus response to chemical response to xenobiotic stimulus import into cell gamma-aminobutyric acid reuptake cellular localization nitrogen compound transport organic anion transport carboxylic acid transport transport amino acid neurotransmitter reuptake neurotransmitter transport establishment of localization organic acid transport amino acid transport localization gamma-aminobutyric acid transport establishment of localization in cell neurotransmitter uptake cellular process neurotransmitter reuptake monocarboxylic acid transport monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport sodium ion transport	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane presynapse presynaptic membrane cell projection GABA-ergic synapse
B [auth H]	9D5 heavy chain	-	-	-
C [auth L]	9D5 light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002982	Sodium:neurotransmitter symporter, GABA, GAT-3	Family
A	IPR000175	Sodium:neurotransmitter symporter	Family
A	IPR037272	Sodium:neurotransmitter symporter superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P48066	melanoma atypical teratoid rhabdoid tumor large cell medulloblastoma cutaneous melanoma malignant glioma schizophrenia glioblastoma medulloblastoma Sjogren syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.