9EPN

Crystal structure of HprS histidine kinase cytoplasmic fragment from Escherichia coli

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Sensor histidine kinase HprS	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups catalytic activity, acting on a protein kinase activity protein kinase activity phosphotransferase activity, alcohol group as acceptor molecular sensor activity phosphotransferase activity, nitrogenous group as acceptor protein histidine kinase activity phosphorelay sensor kinase activity molecular function regulator activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to copper ion response to metal ion response to chemical regulation of biological process phosphorelay signal transduction system regulation of cellular process signaling biological regulation cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to copper ion response to metal ion response to chemical regulation of biological process phosphorelay signal transduction system regulation of cellular process signaling biological regulation intracellular signal transduction cell communication signal transduction response to oxidative stress response to hypochlorite response to oxygen-containing compound response to reactive oxygen species	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004358	Signal transduction histidine kinase-related protein, C-terminal	Domain
A, B	IPR036097	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily	Homologous Superfamily
A, B	IPR003660	HAMP domain	Domain
A, B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B	IPR003661	Signal transduction histidine kinase, dimerisation/phosphoacceptor domain	Domain
A, B	IPR006290	Heavy metal sensor kinase	Family
A, B	IPR003594	Histidine kinase/HSP90-like ATPase domain	Domain
A, B	IPR005467	Histidine kinase domain	Domain
A, B	IPR050428	Two-component system sensor histidine kinase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.