Annotations: 9EQ6

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF01392	Fz domain (Fz)	Fz domain	Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups [1,2,3,4]. The domain contains 10 conserved cysteines.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	Frizzled-5	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity amide binding amyloid-beta binding binding peptide binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding Wnt-protein binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity amide binding amyloid-beta binding binding peptide binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding Wnt-protein binding G protein-coupled receptor activity kinase binding protein kinase binding lipid binding	developmental process multicellular organismal process sensory organ development post-embryonic camera-type eye development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development post-embryonic development sensory system development system development adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains developmental process multicellular organismal process sensory organ development post-embryonic camera-type eye development eye development animal organ development visual system development multicellular organism development camera-type eye development anatomical structure development post-embryonic development sensory system development system development adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response immune effector process regulation of gene expression regulation of leukocyte mediated immunity biosynthetic process regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of response to stimulus regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process adaptive immune response regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response cellular process cellular response to stimulus cell surface receptor signaling pathway signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cell differentiation involved in embryonic placenta development cellular developmental process placenta development reproductive process syncytiotrophoblast cell differentiation involved in labyrinthine layer development chordate embryonic development labyrinthine layer development developmental process involved in reproduction embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching cell differentiation embryonic organ development cell development epithelial cell differentiation intestinal epithelial cell maturation columnar/cuboidal epithelial cell development cell maturation epithelium development digestive system development intestinal epithelial cell differentiation tube development intestinal epithelial cell development developmental maturation tissue development digestive tract development epithelial cell development anatomical structure maturation columnar/cuboidal epithelial cell differentiation epithelial cell maturation columnar/cuboidal epithelial cell maturation embryonic morphogenesis morphogenesis of an epithelium branching involved in labyrinthine layer morphogenesis embryonic placenta morphogenesis anatomical structure morphogenesis labyrinthine layer morphogenesis tissue morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production hemopoiesis cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation glandular epithelial cell development glandular epithelial cell maturation glandular epithelial cell differentiation embryonic eye morphogenesis embryonic camera-type eye development eye morphogenesis animal organ morphogenesis embryonic organ morphogenesis camera-type eye morphogenesis embryonic camera-type eye morphogenesis sensory organ morphogenesis vasculature development circulatory system development positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription apoptotic process involved in development apoptotic process involved in morphogenesis apoptotic process cell death programmed cell death labyrinthine layer blood vessel development placenta blood vessel development blood vessel development blood vessel morphogenesis angiogenesis tube morphogenesis anatomical structure formation involved in morphogenesis cell population proliferation regulation of cell population proliferation regulation of chorionic trophoblast cell proliferation chorionic trophoblast cell proliferation non-canonical Wnt signaling pathway blastoderm segmentation embryonic pattern specification anterior/posterior axis specification, embryo anterior/posterior pattern specification segmentation pattern specification process regionalization tripartite regional subdivision embryonic axis specification anterior/posterior axis specification axis specification extraembryonic membrane development chorion development chorionic trophoblast cell differentiation bicellular tight junction assembly regulation of bicellular tight junction assembly regulation of cellular component organization tight junction organization apical junction assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of cell junction assembly cell junction organization cellular component assembly cell junction assembly tight junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization biological process involved in interspecies interaction between organisms response to other organism response to external stimulus cellular response to molecule of bacterial origin response to biotic stimulus cellular response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin negative regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process Spemann organizer formation developmental induction regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type II interferon production type II interferon production positive regulation of type II interferon production	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane perinuclear region of cytoplasm axon cell surface cell periphery plasma membrane synapse cell junction cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction
B [auth A]	VWFA and cache domain-containing protein 1	-	localization transport monoatomic ion transport monoatomic cation transport establishment of localization calcium ion transport metal ion transport	cellular anatomical structure membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR036790	Frizzled cysteine-rich domain superfamily	Homologous Superfamily
A [auth B]	IPR017981	GPCR, family 2-like, 7TM	Domain
A [auth B]	IPR000539	Frizzled/Smoothened, 7TM	Domain
A [auth B]	IPR020067	Frizzled domain	Domain
A [auth B]	IPR037441	Frizzled-5, CRD domain	Domain
A [auth B]	IPR015526	Frizzled/secreted frizzled-related protein	Family
B [auth A]	IPR051173	Voltage-dependent calcium channel subunit alpha-2/delta	Family
B [auth A]	IPR002035	von Willebrand factor, type A	Domain
B [auth A]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
B [auth A]	IPR029151	Periplasmic sensor-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.