Annotations: 9FNM

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00089	Trypsin (Trypsin)	Trypsin		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Isoform 2 of Haptoglobin alpha chain	antioxidant activity hemoglobin binding protein binding binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process biological regulation reactive oxygen species metabolic process hydrogen peroxide metabolic process negative regulation of biological process regulation of catabolic process regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process negative regulation of hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process biological regulation reactive oxygen species metabolic process hydrogen peroxide metabolic process negative regulation of biological process regulation of catabolic process regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process negative regulation of hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process metabolic process cellular process hydrogen peroxide catabolic process negative regulation of hydrogen peroxide catabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process regulation of molecular function regulation of catalytic activity negative regulation of oxidoreductase activity negative regulation of molecular function negative regulation of catalytic activity regulation of oxidoreductase activity biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus immune system process acute-phase response inflammatory response acute inflammatory response response to hydrogen peroxide response to oxidative stress response to chemical response to oxygen-containing compound response to reactive oxygen species zymogen activation primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing protein metabolic process macromolecule metabolic process	protein-containing complex haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular anatomical structure protein-containing complex haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule endocytic vesicle lumen endocytic vesicle
B	Haptoglobin beta chain	antioxidant activity hemoglobin binding protein binding binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process biological regulation reactive oxygen species metabolic process hydrogen peroxide metabolic process negative regulation of biological process regulation of catabolic process regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process negative regulation of hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process negative regulation of catabolic process regulation of biological process catabolic process regulation of cellular process negative regulation of metabolic process biological regulation reactive oxygen species metabolic process hydrogen peroxide metabolic process negative regulation of biological process regulation of catabolic process regulation of hydrogen peroxide catabolic process negative regulation of reactive oxygen species metabolic process negative regulation of hydrogen peroxide metabolic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process metabolic process cellular process hydrogen peroxide catabolic process negative regulation of hydrogen peroxide catabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process regulation of molecular function regulation of catalytic activity negative regulation of oxidoreductase activity negative regulation of molecular function negative regulation of catalytic activity regulation of oxidoreductase activity biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus immune system process acute-phase response inflammatory response acute inflammatory response response to hydrogen peroxide response to oxidative stress response to chemical response to oxygen-containing compound response to reactive oxygen species zymogen activation primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing protein metabolic process macromolecule metabolic process	protein-containing complex haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular anatomical structure protein-containing complex haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule endocytic vesicle lumen endocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000436	Sushi/SCR/CCP domain	Domain
A	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B	IPR000436	Sushi/SCR/CCP domain	Domain
B	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
B	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B	IPR001314	Peptidase S1A, chymotrypsin family	Family
B	IPR001254	Serine proteases, trypsin domain	Domain
B	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P00738	anemia hereditary hemochromatosis sickle cell anemia malaria tuberculosis arthritic joint disease retinal detachment breast carcinoma chronic hepatitis B virus infection type 2 diabetes mellitus diabetic peripheral angiopathy Dyslipidemias myocardial infarction anhaptoglobinemia hepatitis B virus infection anemia hereditary hemochromatosis sickle cell anemia malaria tuberculosis arthritic joint disease retinal detachment breast carcinoma chronic hepatitis B virus infection type 2 diabetes mellitus diabetic peripheral angiopathy Dyslipidemias myocardial infarction anhaptoglobinemia hepatitis B virus infection autoimmune disease leukemia allergic disease atherosclerosis HIV infectious disease schizophrenia hypertensive disorder cardiovascular disease type 1 diabetes mellitus lung adenocarcinoma major depressive disorder MALT lymphoma maturity-onset diabetes of the young acute kidney failure osteosarcoma heart disease pituitary cancer atypical teratoid rhabdoid tumor depressive disorder lung cancer female reproductive organ cancer ovarian cancer hypertension, pregnancy-induced sinusitis interstitial cystitis chronic hepatitis C virus infection lung carcinoma female reproductive system neoplasm non-small cell lung carcinoma arteriosclerosis disorder breast cancer thrombocytopenia
B	Pharos: P00738	anemia hereditary hemochromatosis sickle cell anemia malaria tuberculosis arthritic joint disease retinal detachment breast carcinoma chronic hepatitis B virus infection type 2 diabetes mellitus diabetic peripheral angiopathy Dyslipidemias myocardial infarction anhaptoglobinemia hepatitis B virus infection anemia hereditary hemochromatosis sickle cell anemia malaria tuberculosis arthritic joint disease retinal detachment breast carcinoma chronic hepatitis B virus infection type 2 diabetes mellitus diabetic peripheral angiopathy Dyslipidemias myocardial infarction anhaptoglobinemia hepatitis B virus infection autoimmune disease leukemia allergic disease atherosclerosis HIV infectious disease schizophrenia hypertensive disorder cardiovascular disease type 1 diabetes mellitus lung adenocarcinoma major depressive disorder MALT lymphoma maturity-onset diabetes of the young acute kidney failure osteosarcoma heart disease pituitary cancer atypical teratoid rhabdoid tumor depressive disorder lung cancer female reproductive organ cancer ovarian cancer hypertension, pregnancy-induced sinusitis interstitial cystitis chronic hepatitis C virus infection lung carcinoma female reproductive system neoplasm non-small cell lung carcinoma arteriosclerosis disorder breast cancer thrombocytopenia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.