9GZ1 | pdb_00009gz1

Beta-cardiac myosin interacting heads motif complexed to mavacamten

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	EF-hand	8102867	3001983	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	EF-hand	8102867	3001983	SCOP2B (2022-06-29)
E [auth D]	SCOP2B Superfamily	EF-hand	8102889	3001983	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	EF-hand	8102889	3001983	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02736	Myosin N-terminal SH3-like domain (Myosin_N)	Myosin N-terminal SH3-like domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	Domain
A, B	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)		Domain
E [auth D], F	PF13405	EF-hand domain (EF-hand_6)	EF-hand domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Myosin-7	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding calmodulin binding polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity microfilament motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate muscle contraction muscle system process striated muscle contraction nucleoside phosphate metabolic process ribose phosphate metabolic process purine nucleoside triphosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process regulation of the force of heart contraction regulation of muscle adaptation striated muscle adaptation response to stimulus transition between fast and slow fiber regulation of skeletal muscle adaptation regulation of muscle system process muscle adaptation regulation of response to stimulus skeletal muscle adaptation slow-twitch skeletal muscle fiber contraction twitch skeletal muscle contraction multicellular organismal movement musculoskeletal movement regulation of twitch skeletal muscle contraction regulation of skeletal muscle contraction regulation of slow-twitch skeletal muscle fiber contraction nervous system process neuromuscular process skeletal muscle contraction voluntary skeletal muscle contraction regulation of striated muscle contraction regulation of muscle contraction muscle filament sliding actin filament-based process actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding cardiac muscle contraction developmental process heart development multicellular organism development anatomical structure development animal organ development adult heart development circulatory system development system development ventricular cardiac muscle tissue morphogenesis heart morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development cardiac chamber morphogenesis cardiac muscle tissue development tissue development muscle tissue morphogenesis anatomical structure morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of the force of skeletal muscle contraction regulation of skeletal muscle contraction by chemo-mechanical energy conversion muscle hypertrophy striated muscle hypertrophy cardiac muscle adaptation response to stress cardiac muscle hypertrophy cardiac muscle hypertrophy in response to stress muscle hypertrophy in response to stress	intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex protein-containing complex actin cytoskeleton myosin complex cytoskeleton myosin II complex muscle myosin complex myosin filament actin filament bundle actomyosin stress fiber contractile actin filament bundle
C, D [auth E]	Myosin light chain 1/3, skeletal muscle isoform	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding structural molecule activity structural constituent of muscle	multicellular organismal process system process muscle contraction muscle system process	intracellular anatomical structure intracellular membraneless organelle intracellular organelle cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex protein-containing complex cytoskeleton intracellular anatomical structure intracellular membraneless organelle intracellular organelle cellular anatomical structure organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex protein-containing complex cytoskeleton actin cytoskeleton myosin complex
E [auth D], F	Myosin regulatory light chain 11	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding structural molecule activity structural constituent of muscle	multicellular organismal process system process muscle contraction muscle system process developmental process muscle structure development skeletal muscle organ development skeletal muscle tissue development anatomical structure development animal organ development muscle tissue development muscle organ development tissue development striated muscle tissue development multicellular organismal process system process muscle contraction muscle system process developmental process muscle structure development skeletal muscle organ development skeletal muscle tissue development anatomical structure development animal organ development muscle tissue development muscle organ development tissue development striated muscle tissue development response to stimulus immune response immune system process	intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton myosin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR001609	Myosin head, motor domain-like	Domain
A, B	IPR000048	IQ motif, EF-hand binding site	Binding Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A, B	IPR002928	Myosin tail	Domain
A, B	IPR004009	Myosin, N-terminal, SH3-like	Domain
A, B	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily
C, D [auth E]	IPR050230	Calmodulin/Myosin light chain/Troponin C-like	Family
C, D [auth E]	IPR002048	EF-hand domain	Domain
C, D [auth E]	IPR011992	EF-hand domain pair	Homologous Superfamily
E [auth D], F	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
E [auth D], F	IPR002048	EF-hand domain	Domain
E [auth D], F	IPR011992	EF-hand domain pair	Homologous Superfamily
E [auth D], F	IPR050403	Myosin regulatory light chain	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P12883	myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy myopathy, myosin storage, autosomal dominant dilated cardiomyopathy myopathy, myosin storage, autosomal recessive hypertrophic cardiomyopathy left ventricular noncompaction congenital fiber-type disproportion myopathy dilated cardiomyopathy 1S MYH7-related skeletal myopathy distal myopathy Ebstein anomaly hypertrophic cardiomyopathy 1 cardiomyopathy myocardial infarction tibial muscular dystrophy congenital structural myopathy MYH7-related late-onset scapuloperoneal muscular dystrophy atrial fibrillation centronuclear myopathy coronary stenosis familial dilated cardiomyopathy heart disease LEFT VENTRICULAR NONCOMPACTION 5 arthrogryposis autosomal dominant centronuclear myopathy Charcot-Marie-Tooth disease scapuloperoneal myopathy familial hypertrophic cardiomyopathy hyaline body myopathy malignant ependymoma psoriasis X-linked centronuclear myopathy dilated cardiomyopathy 1A familial isolated dilated cardiomyopathy myopathy autosomal recessive centronuclear myopathy myotonia congenita restrictive cardiomyopathy tubular aggregate myopathy X-linked Emery-Dreifuss muscular dystrophy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.