9IWW | pdb_00009iww

Crystal structure of the mouse RIP3 kinase domain in complexed with GSK'872

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Receptor-interacting serine/threonine-protein kinase 3	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups histone H2AS121 kinase activity histone modifying activity histone H2A kinase activity catalytic activity histone kinase activity AMP-activated protein kinase activity DNA-dependent protein kinase activity histone H3T45 kinase activity histone H3 kinase activity eukaryotic translation initiation factor 2alpha kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding histone H3T6 kinase activity histone H3T3 kinase activity histone H2BS14 kinase activity histone H2B kinase activity identical protein binding protein binding histone H3S57 kinase activity Rho-dependent protein serine/threonine kinase activity histone H2AT120 kinase activity histone H2AXS139 kinase activity histone H2AX kinase activity histone H4S1 kinase activity histone H4 kinase activity protein serine kinase activity histone H3T11 kinase activity histone H3S28 kinase activity 3-phosphoinositide-dependent protein kinase activity histone H2BS36 kinase activity histone H2AS1 kinase activity ribosomal protein S6 kinase activity histone H3S10 kinase activity	developmental process immune system development multicellular organism development multicellular organismal process lymph node development immune system process animal organ development anatomical structure development hematopoietic or lymphoid organ development system development cellular process apoptotic process cell death programmed cell death developmental process immune system development multicellular organism development multicellular organismal process lymph node development immune system process animal organ development anatomical structure development hematopoietic or lymphoid organ development system development cellular process apoptotic process cell death programmed cell death regulation of biological process response to stimulus regulation of adaptive immune response immune response regulation of response to stimulus biological regulation regulation of immune response regulation of immune system process adaptive immune response regulation of cell motility regulation of cellular process regulation of CD8-positive, alpha-beta T cell extravasation CD8-positive, alpha-beta T cell extravasation regulation of lymphocyte migration regulation of cell migration cellular extravasation regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation regulation of T cell extravasation cell migration cell motility regulation of mononuclear cell migration locomotion T cell extravasation regulation of leukocyte migration lymphocyte migration CD8-positive, alpha-beta cytotoxic T cell extravasation leukocyte migration regulation of locomotion regulation of T cell migration mononuclear cell migration T cell migration regulation of cellular extravasation regulation of biosynthetic process regulation of type II interferon production type II interferon production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process cytokine production regulation of cytokine production metabolic process regulation of macromolecule biosynthetic process regulation of multicellular organismal process macromolecule metabolic process regulation of metabolic process regulation of apoptotic process regulation of programmed cell death cellular response to stimulus signaling necroptotic process programmed necrotic cell death cell communication necroptotic signaling pathway signal transduction non-canonical NF-kappaB signal transduction intracellular signal transduction intracellular signaling cassette regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein kinase activity phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of cellular process protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity primary metabolic process regulation of protein kinase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains leukocyte mediated immunity regulation of T cell mediated immunity T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity immune effector process regulation of T cell mediated cytotoxicity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity regulation of cell killing cell killing cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation cell differentiation T cell differentiation leukocyte differentiation regulation of activated T cell proliferation regulation of leukocyte activation regulation of cell activation leukocyte proliferation activated T cell proliferation lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation regulation of T cell activation regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation spleen development execution phase of necroptosis positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction intrinsic apoptotic signaling pathway regulation of signaling positive regulation of programmed cell death positive regulation of intracellular signal transduction positive regulation of apoptotic process apoptotic signaling pathway regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus gland development thymus development reactive oxygen species metabolic process cellular component organization cellular component organization or biogenesis supramolecular fiber organization amyloid fibril formation multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to chemical stimulus cellular response to stress response to chemical positive regulation of necroptotic process regulation of necroptotic process regulation of programmed necrotic cell death positive regulation of programmed necrotic cell death leukocyte apoptotic process lymphocyte apoptotic process regulation of activation-induced cell death of T cells activation-induced cell death of T cells regulation of T cell apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process T cell apoptotic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR025735	RIP homotypic interaction motif	Binding Site
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR051681	Serine/Threonine Kinases and Pseudokinases	Family
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.