Annotations: 9J7A

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth D]	PF12796	Ankyrin repeats (3 copies) (Ank_2)	Ankyrin repeats (3 copies)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth D]	Protein fem-1 homolog B	protein binding binding signaling receptor binding cytokine receptor binding tumor necrosis factor receptor superfamily binding death receptor binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding metal ion binding small molecule binding	catabolic process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process catabolic process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process multicellular organismal process prostate gland development reproductive process gland development developmental process involved in reproduction prostate gland epithelium morphogenesis multicellular organism development gland morphogenesis anatomical structure development reproductive structure development animal organ morphogenesis system development developmental process epithelium development reproductive system development animal organ development morphogenesis of an epithelium urogenital system development tissue development prostate gland morphogenesis tissue morphogenesis anatomical structure morphogenesis morphogenesis of a branching structure branching involved in prostate gland morphogenesis morphogenesis of a branching epithelium apoptotic process cell death programmed cell death cellular response to stimulus extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process response to stimulus signaling regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway cell communication signal transduction regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of apoptotic process biological regulation regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication regulation of apoptotic signaling pathway protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of molecular function regulation of catalytic activity regulation of ubiquitin-protein transferase activity regulation of transferase activity DNA damage checkpoint signaling regulation of cell cycle phase transition negative regulation of biological process regulation of cellular response to stress negative regulation of cell cycle cell cycle phase transition intracellular signal transduction regulation of cell cycle checkpoint cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage regulation of DNA damage checkpoint epithelial cell maturation involved in prostate gland development cellular developmental process cell development epithelial cell differentiation cell differentiation cell maturation epithelial cell differentiation involved in prostate gland development developmental maturation epithelial cell development anatomical structure maturation epithelial cell maturation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex cullin-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex
B, C	Mitochondrial import receptor subunit TOM20 homolog	signal sequence binding binding peptide binding mitochondrion targeting sequence binding unfolded protein binding protein binding macromolecule transmembrane transporter activity active transmembrane transporter activity protein transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity protein transmembrane transporter activity protein-transporting ATPase activity transporter activity signal sequence binding binding peptide binding mitochondrion targeting sequence binding unfolded protein binding protein binding macromolecule transmembrane transporter activity active transmembrane transporter activity protein transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity protein transmembrane transporter activity protein-transporting ATPase activity transporter activity transmembrane transporter activity ATP-dependent activity	response to stimulus response to activity response to muscle activity protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion response to stimulus response to activity response to muscle activity protein localization establishment of protein localization cellular localization protein targeting establishment of localization localization establishment of protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion cellular process establishment of protein localization to mitochondrion response to 3,3',5-triiodo-L-thyronine response to acid chemical response to chemical response to oxygen-containing compound response to nitrogen compound response to amino acid nitrogen compound transport transport establishment of protein localization to mitochondrial membrane mitochondrial membrane organization cellular component organization outer mitochondrial membrane organization establishment of localization in cell cellular component organization or biogenesis mitochondrial transport mitochondrion organization membrane organization establishment of protein localization to membrane protein insertion into mitochondrial outer membrane intracellular transport localization within membrane protein localization to membrane organelle organization protein transport intracellular protein transport protein transmembrane import into intracellular organelle protein import into mitochondrial matrix protein transmembrane transport mitochondrial transmembrane transport transmembrane transport import into the mitochondrion RNA transport nucleic acid transport tRNA transport RNA import into mitochondrion establishment of RNA localization tRNA import into mitochondrion RNA localization nucleobase-containing compound transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle membrane contact site mitochondria-associated endoplasmic reticulum membrane contact site mitochondrial protein-containing complex protein-containing complex mitochondrial membrane outer mitochondrial membrane protein complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle organelle membrane contact site mitochondria-associated endoplasmic reticulum membrane contact site mitochondrial protein-containing complex protein-containing complex mitochondrial membrane outer mitochondrial membrane protein complex membrane membrane protein complex organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane mitochondrial outer membrane translocase complex outer membrane organelle membrane cell periphery cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection TOM complex migrasome
D [auth F], F [auth E]	Poly-UNK	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth D]	IPR002110	Ankyrin repeat	Repeat
A, E [auth D]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
B, C	IPR023392	Mitochondrial outer membrane translocase complex, Tom20 domain superfamily	Homologous Superfamily
B, C	IPR022422	Protein import receptor MAS20, metazoan	Family
B, C	IPR002056	Protein import receptor MAS20	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E [auth D]	Pharos: Q9UK73	tuberculosis astrocytic tumor dermatomyositis gastric carcinoma juvenile dermatomyositis malignant glioma medulloblastoma plantar fibromatosis atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma glioblastoma large cell medulloblastoma malignant mesothelioma myopathy plasma cell myeloma tuberculosis astrocytic tumor dermatomyositis gastric carcinoma juvenile dermatomyositis malignant glioma medulloblastoma plantar fibromatosis atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma glioblastoma large cell medulloblastoma malignant mesothelioma myopathy plasma cell myeloma breast cancer gastric cancer hepatocellular carcinoma malignant colon neoplasm malignant pancreatic neoplasm ovarian cancer
B, C	Pharos: Q15388	atypical teratoid rhabdoid tumor malignant ependymoma psoriasis glioblastoma ovarian cancer lung cancer plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.