9MFO | pdb_00009mfo

Human DHX9 in Complex with Compound 1 and ADP

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ATP-dependent RNA helicase A	chromatin binding binding promoter-specific chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding chromatin binding binding promoter-specific chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding RNA binding transcription regulatory region nucleic acid binding regulatory region RNA binding nucleic acid conformation isomerase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity 3'-5' DNA helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity cation binding metal ion binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding DNA replication origin binding regulatory RNA binding siRNA binding sequence-specific mRNA binding mRNA binding chromatin DNA binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides protein binding importin-alpha family protein binding single-stranded DNA binding 3'-5' DNA/RNA helicase activity catalytic activity, acting on RNA ATP-dependent activity, acting on RNA DNA/RNA helicase activity double-stranded RNA binding RNA helicase activity RNA stem-loop binding transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription coactivator activity single-stranded RNA binding RNA polymerase binding enzyme binding 3'-5' RNA helicase activity single-stranded DNA helicase activity single-stranded 3'-5' DNA helicase activity triplex DNA binding RISC complex binding basal transcription machinery binding RNA polymerase II complex binding basal RNA polymerase II transcription machinery binding RNA polymerase core enzyme binding nucleoside triphosphate diphosphatase activity	regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA stabilization regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA stabilization mRNA catabolic process regulation of biological process negative regulation of metabolic process primary metabolic process nucleobase-containing compound catabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of RNA metabolic process catabolic process positive regulation of biological process RNA metabolic process macromolecule catabolic process negative regulation of mRNA metabolic process regulation of mRNA catabolic process positive regulation of biosynthetic process negative regulation of cellular process positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of catabolic process biological regulation negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of mRNA stability CRD-mediated mRNA stabilization RNA stabilization negative regulation of biosynthetic process positive regulation of gene expression regulation of RNA stability cellular process regulation of mRNA metabolic process cellular response to stimulus response to stimulus regulation of cellular response to stress positive regulation of response to stimulus positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress DNA repair positive regulation of nucleobase-containing compound metabolic process DNA metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of response to stimulus DNA damage response regulation of DNA metabolic process RNA splicing alternative mRNA splicing, via spliceosome nucleobase-containing compound biosynthetic process mRNA processing RNA biosynthetic process nucleic acid biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing multicellular organismal process interferon-alpha production cytokine production regulation of cytokine production regulation of multicellular organismal process regulation of interferon-alpha production positive regulation of type I interferon production type I interferon production positive regulation of interferon-alpha production positive regulation of multicellular organismal process positive regulation of cytokine production regulation of type I interferon production cellular component organization chromatin organization cellular component organization or biogenesis viral gene expression regulation of viral process regulation of viral transcription positive regulation of viral process viral process viral transcription positive regulation of viral transcription cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly regulation of localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of nucleobase-containing compound transport localization positive regulation of RNA export from nucleus establishment of localization in cell positive regulation of intracellular transport RNA localization nuclear export nucleobase-containing compound transport regulation of intracellular transport RNA transport regulation of transport regulation of nucleobase-containing compound transport regulation of RNA export from nucleus nucleic acid transport intracellular transport regulation of nucleocytoplasmic transport establishment of localization RNA export from nucleus establishment of RNA localization positive regulation of transport regulation of cellular localization macromolecule localization mRNA transport cellular response to nitrogen compound cellular response to dsRNA cellular response to exogenous dsRNA response to dsRNA response to nitrogen compound response to exogenous dsRNA cellular response to chemical stimulus response to chemical regulation of interferon-beta production interferon-beta production positive regulation of interferon-beta production positive regulation of protein metabolic process positive regulation of translation positive regulation of cytoplasmic translation protein metabolic process regulation of protein metabolic process translation regulation of translation cytoplasmic translation regulation of cytoplasmic translation regulation of mRNA processing positive regulation of interleukin-18 production regulation of interleukin-18 production interleukin-18 production regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to biotic stimulus positive regulation of response to external stimulus positive regulation of immune response innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus immune system process defense response to other organism positive regulation of defense response regulation of immune response regulation of defense response to virus defense response to virus regulation of defense response to virus by host response to virus regulation of inflammatory response positive regulation of inflammatory response inflammatory response positive regulation of DNA replication DNA replication regulation of DNA replication DNA-templated transcription termination DNA-templated transcription response to cytokine positive regulation of response to cytokine stimulus response to peptide regulation of response to cytokine stimulus positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of molecular function regulation of RNA biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription ribonucleoprotein complex biogenesis RISC complex assembly protein-RNA complex assembly protein-RNA complex organization regulatory ncRNA-mediated gene silencing protein localization protein localization to cytoplasmic stress granule protein localization to organelle cellular macromolecule localization positive regulation of DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulatory ncRNA-mediated post-transcriptional gene silencing miRNA-mediated post-transcriptional gene silencing post-transcriptional gene silencing developmental process cellular developmental process ossification cell differentiation osteoblast differentiation interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production fibroblast proliferation cell population proliferation positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of mRNA metabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay mRNA destabilization regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay RNA destabilization nuclear-transcribed mRNA catabolic process positive regulation of catabolic process positive regulation of mRNA catabolic process rhythmic process DNA-templated viral transcription pyroptotic inflammatory response	protein-containing complex ribonucleoprotein complex RNAi effector complex RISC complex intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol protein-containing complex ribonucleoprotein complex RNAi effector complex RISC complex intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen organelle lumen nuclear lumen cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule CRD-mediated mRNA stability complex intracellular protein-containing complex nuclear body nucleoplasm membrane perichromatin fibrils nuclear chromosome chromosome chromatin centrosome microtubule organizing center microtubule cytoskeleton RISC-loading complex endoribonuclease complex catalytic complex endonuclease complex nuclear stress granule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR048333	Helicase associated domain (HA2), winged-helix domain	Domain
A	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	Conserved Site
A	IPR044446	DHX9, second double-stranded RNA binding domain	Domain
A	IPR011545	DEAD/DEAH box helicase domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR001650	Helicase, C-terminal domain-like	Domain
A	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A	IPR044447	DHX9, DEXH-box helicase domain	Domain
A	IPR011709	DEAD-box helicase, OB fold	Domain
A	IPR007502	Helicase-associated domain	Domain
A	IPR044445	DHX9, first double-stranded RNA binding domain	Domain
A	IPR014720	Double-stranded RNA-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q08211	astrocytic tumor glioblastoma malignant ependymoma oligodendroglioma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma osteosarcoma psoriasis Gaucher disease lung cancer medulloblastoma plasma cell myeloma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.