9NKG | pdb_00009nkg

Structure of substrate engaged MIDN-bound human 26S proteasome, EB-MIDN (Composite map)

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth G], O [auth g]	Proteasome subunit alpha type-6	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding RNA binding nucleic acid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity purine ribonucleoside triphosphate binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding NF-kappaB binding RNA binding nucleic acid binding peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity endopeptidase activity purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding anion binding heterocyclic compound binding small molecule binding	catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of DNA-binding transcription factor activity regulation of cellular process positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process regulation of defense response response to stimulus regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stimulus response to stress regulation of response to stress inflammatory response	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell projection cilium plasma membrane bounded cell projection nucleus membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cell projection cilium plasma membrane bounded cell projection nucleus membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear lumen nuclear matrix protein-containing complex proteasome core complex, alpha-subunit complex catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol nucleoplasm membraneless organelle intracellular membraneless organelle ribosome sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule P-body
B [auth H], P [auth h]	Proteasome subunit alpha type-2	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule membraneless organelle supramolecular complex P-body ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
D [auth J], R [auth j]	Proteasome subunit alpha type-7	identical protein binding protein binding binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
E [auth K], S [auth k]	Proteasome subunit alpha type-5	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region intracellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
F [auth L], T [auth l]	Proteasome subunit alpha type-1	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	immune system process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response immune system process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus biological regulation response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
G [auth M], U [auth m]	Proteasome subunit alpha type-3	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
H [auth N], V [auth n]	Proteasome subunit beta type-6	cell adhesion molecule binding cadherin binding protein binding binding peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
J [auth P], X [auth p]	Proteasome subunit beta type-3	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
K [auth Q], Y [auth q]	Proteasome subunit beta type-2	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
L [auth R], Z [auth r]	Proteasome subunit beta type-5	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis response to oxidative stress response to stimulus response to stress proteolysis metabolic process primary metabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis response to oxidative stress response to stimulus response to stress proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
AA [auth s], M [auth S]	Proteasome subunit beta type-1	-	catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process catabolic process proteolysis involved in protein catabolic process proteolysis metabolic process cellular process primary metabolic process protein catabolic process protein metabolic process macromolecule metabolic process macromolecule catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome core complex proteasome core complex, beta-subunit complex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
BA [auth t], N [auth T]	Proteasome subunit beta type-4	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus regulation of biological process defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus biological regulation response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen intracellular membraneless organelle cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton
CA [auth A]	26S proteasome regulatory subunit 7	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen membraneless organelle cytoplasmic ribonucleoprotein granule intracellular membraneless organelle supramolecular complex ribonucleoprotein granule extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen P-body
DA [auth B]	26S proteasome regulatory subunit 4	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity RNA binding nucleic acid binding polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
FA [auth D]	26S proteasome regulatory subunit 6B	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development proteolysis metabolic process cellular process primary metabolic process protein metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular membraneless organelle cilium plasma membrane bounded cell projection ciliary basal body cell projection microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton
GA [auth E]	26S proteasome regulatory subunit 10B	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	-	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex
IA [auth V]	26S proteasome non-ATPase regulatory subunit 3	enzyme regulator activity molecular function regulator activity catalytic activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process regulation of biological process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process regulation of biological process regulation of cellular process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of primary metabolic process regulation of metabolic process regulation of protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
KA [auth X]	26S proteasome non-ATPase regulatory subunit 11	structural molecule activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process cellular component organization catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis developmental process stem cell differentiation cellular developmental process cell differentiation proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
LA [auth Y]	26S proteasome non-ATPase regulatory subunit 6	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
MA [auth Z]	26S proteasome non-ATPase regulatory subunit 7	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure membrane proteasome accessory complex intracellular anatomical structure proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cellular anatomical structure membrane proteasome accessory complex intracellular anatomical structure proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
NA [auth a]	26S proteasome non-ATPase regulatory subunit 13	structural molecule activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process sexual reproduction catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process sexual reproduction reproductive process meiotic cell cycle organelle fission meiotic cell cycle process cellular component organization nuclear division organelle organization meiosis I meiosis I cell cycle process meiotic nuclear division cell cycle cellular component organization or biogenesis cell cycle process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
OA [auth b]	26S proteasome non-ATPase regulatory subunit 4	polyubiquitin modification-dependent protein binding protein binding binding modification-dependent protein binding molecular adaptor activity RNA binding nucleic acid binding identical protein binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
PA [auth d]	26S proteasome non-ATPase regulatory subunit 8	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol proteasome accessory complex protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol proteasome accessory complex protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
QA [auth e]	26S proteasome complex subunit SEM1	-	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle integrator complex organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
RA [auth v]	unknown density (substrate density)	-	-	-
TA [auth c]	26S proteasome non-ATPase regulatory subunit 14	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity protein-containing complex binding binding proteasome binding enzyme regulator activity peptidase regulator activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity ubiquitin-like protein peptidase activity metal-dependent deubiquitinase activity deubiquitinase activity K63-linked deubiquitinase activity protein-containing complex binding binding proteasome binding enzyme regulator activity peptidase regulator activity molecular function activator activity peptidase activator activity endopeptidase regulator activity endopeptidase activator activity enzyme activator activity molecular function regulator activity endopeptidase activity cation binding ion binding metal ion binding small molecule binding	protein deubiquitination protein K63-linked deubiquitination primary metabolic process protein modification by small protein removal macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal catabolic process proteolysis involved in protein catabolic process protein deubiquitination protein K63-linked deubiquitination primary metabolic process protein modification by small protein removal macromolecule modification metabolic process cellular process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process response to stimulus response to alcohol response to chemical response to oxygen-containing compound response to ethanol cellular response to stimulus double-strand break repair DNA recombination DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair regulation of cellular process regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process regulation of proteasomal protein catabolic process regulation of metabolic process regulation of protein catabolic process double-strand break repair via nonhomologous end joining	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex cytoplasm cytosol proteasome regulatory particle proteasome regulatory particle, lid subcomplex membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen cytosolic proteasome complex extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen
UA [auth f]	26S proteasome non-ATPase regulatory subunit 2	enzyme regulator activity molecular function regulator activity catalytic activity	regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex extracellular exosome proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol membraneless organelle intracellular membraneless organelle proteasome storage granule ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
VA [auth z]	Midnolin	protein binding binding kinase binding enzyme binding molecular adaptor activity	catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process proteolysis metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of cellular process regulation of catalytic activity catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process proteasomal ubiquitin-independent protein catabolic process macromolecule catabolic process proteolysis metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of cellular process regulation of catalytic activity negative regulation of biological process negative regulation of glucokinase activity negative regulation of phosphate metabolic process negative regulation of catalytic activity regulation of transferase activity regulation of primary metabolic process negative regulation of hexokinase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of cellular process phosphorus metabolic process regulation of carbohydrate metabolic process negative regulation of carbohydrate metabolic process carbohydrate metabolic process regulation of biological process phosphorylation negative regulation of metabolic process biological regulation negative regulation of molecular function regulation of molecular function regulation of kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of metabolic process protein localization negative regulation of protein transport regulation of localization establishment of protein localization nitrogen compound transport negative regulation of transport cell communication localization negative regulation of secretion cellular macromolecule localization negative regulation of hormone secretion negative regulation of secretion by cell regulation of biological quality regulation of peptide hormone secretion negative regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region negative regulation of establishment of protein localization protein secretion establishment of localization regulation of protein secretion regulation of secretion negative regulation of protein secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport signaling negative regulation of signaling hormone secretion negative regulation of cell communication protein localization to extracellular region negative regulation of peptide secretion peptide secretion regulation of secretion by cell secretion by cell amide transport signal release negative regulation of protein localization regulation of signaling regulation of transport secretion regulation of peptide transport regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport peptide transport negative regulation of insulin secretion protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport regulation of cell communication insulin secretion	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen
EA [auth C]	26S protease regulatory subunit 8	transcription factor binding protein binding binding general transcription initiation factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding transcription factor binding protein binding binding general transcription initiation factor binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA-binding transcription factor binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity peptide hormone receptor binding signaling receptor binding G protein-coupled receptor binding thyrotropin-releasing hormone receptor binding hormone receptor binding polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process regulation of protein catabolic process negative regulation of programmed cell death regulation of programmed cell death cell death programmed cell death proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen cytoplasmic vesicle intracellular vesicle blood microparticle
HA [auth F]	26S proteasome regulatory subunit 6A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity identical protein binding protein binding polypeptide conformation or assembly isomerase activity isomerase activity proteasome-activating activity macromolecular conformation isomerase activity	modulation by host of viral transcription viral gene expression modulation by host of viral process biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription viral process negative regulation by host of viral process modulation of process of another organism viral transcription host-mediated perturbation of symbiont process positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process modulation by host of viral transcription viral gene expression modulation by host of viral process biological process involved in interspecies interaction between organisms negative regulation by host of viral transcription viral process negative regulation by host of viral process modulation of process of another organism viral transcription host-mediated perturbation of symbiont process positive regulation of proteasomal protein catabolic process regulation of cellular process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biological process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen organelle secretory granule secretory vesicle vesicle nucleus nucleoplasm nuclear lumen extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule membraneless organelle supramolecular complex P-body
JA [auth W]	26S proteasome non-ATPase regulatory subunit 12	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm cytosol proteasome regulatory particle, lid subcomplex ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen
C [auth I], Q [auth i]	Proteasome subunit alpha type-4	-	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex intracellular anatomical structure cellular anatomical structure proteasome core complex, alpha-subunit complex proteasome core complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol intracellular organelle intracellular membrane-bounded organelle cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule membraneless organelle supramolecular complex P-body nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
SA [auth U]	26S proteasome non-ATPase regulatory subunit 1	ubiquitin protein ligase binding protein binding binding ubiquitin-like protein ligase binding enzyme binding enzyme regulator activity molecular function regulator activity catalytic activity	regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process regulation of biological process regulation of cellular process catabolic process regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex cytoplasm proteasome accessory complex protein-containing complex intracellular anatomical structure cellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex membrane proteasome regulatory particle extracellular region proteasome regulatory particle, base subcomplex cytoplasm cytosol membrane-bounded organelle lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen organelle secretory granule primary lysosome secretory vesicle membraneless organelle intracellular membraneless organelle proteasome storage granule nucleus nucleoplasm nuclear lumen
I [auth O], W [auth o]	Proteasome subunit beta type-7	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process	membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region vesicle lumen membrane-bounded organelle cell projection cellular anatomical structure organelle cilium plasma membrane bounded cell projection protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex extracellular region vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm vesicle cytosol proteasome core complex proteasome core complex, beta-subunit complex nucleus nuclear body nucleoplasm nuclear lumen ficolin-1-rich granule ficolin-1-rich granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth G], O [auth g]	IPR034642	Proteasome subunit alpha6	Family
A [auth G], O [auth g]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
A [auth G], O [auth g]	IPR050115	Proteasome subunit alpha	Family
A [auth G], O [auth g]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
A [auth G], O [auth g]	IPR023332	Proteasome alpha-type subunit	Family
A [auth G], O [auth g]	IPR001353	Proteasome, subunit alpha/beta	Family
B [auth H], P [auth h]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
B [auth H], P [auth h]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
B [auth H], P [auth h]	IPR050115	Proteasome subunit alpha	Family
B [auth H], P [auth h]	IPR023332	Proteasome alpha-type subunit	Family
B [auth H], P [auth h]	IPR001353	Proteasome, subunit alpha/beta	Family
D [auth J], R [auth j]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
D [auth J], R [auth j]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
D [auth J], R [auth j]	IPR050115	Proteasome subunit alpha	Family
D [auth J], R [auth j]	IPR023332	Proteasome alpha-type subunit	Family
D [auth J], R [auth j]	IPR001353	Proteasome, subunit alpha/beta	Family
E [auth K], S [auth k]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
E [auth K], S [auth k]	IPR033812	Proteasome subunit alpha5	Family
E [auth K], S [auth k]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
E [auth K], S [auth k]	IPR050115	Proteasome subunit alpha	Family
E [auth K], S [auth k]	IPR023332	Proteasome alpha-type subunit	Family
E [auth K], S [auth k]	IPR001353	Proteasome, subunit alpha/beta	Family
F [auth L], T [auth l]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
F [auth L], T [auth l]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
F [auth L], T [auth l]	IPR050115	Proteasome subunit alpha	Family
F [auth L], T [auth l]	IPR035144	Proteasome subunit alpha 1	Family
F [auth L], T [auth l]	IPR023332	Proteasome alpha-type subunit	Family
F [auth L], T [auth l]	IPR001353	Proteasome, subunit alpha/beta	Family
G [auth M], U [auth m]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
G [auth M], U [auth m]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
G [auth M], U [auth m]	IPR050115	Proteasome subunit alpha	Family
G [auth M], U [auth m]	IPR023332	Proteasome alpha-type subunit	Family
G [auth M], U [auth m]	IPR001353	Proteasome, subunit alpha/beta	Family
H [auth N], V [auth n]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
H [auth N], V [auth n]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
H [auth N], V [auth n]	IPR023333	Proteasome B-type subunit	Family
H [auth N], V [auth n]	IPR001353	Proteasome, subunit alpha/beta	Family
H [auth N], V [auth n]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
J [auth P], X [auth p]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
J [auth P], X [auth p]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
J [auth P], X [auth p]	IPR023333	Proteasome B-type subunit	Family
J [auth P], X [auth p]	IPR001353	Proteasome, subunit alpha/beta	Family
J [auth P], X [auth p]	IPR033811	Proteasome beta 3 subunit	Family
K [auth Q], Y [auth q]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
K [auth Q], Y [auth q]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
K [auth Q], Y [auth q]	IPR023333	Proteasome B-type subunit	Family
K [auth Q], Y [auth q]	IPR001353	Proteasome, subunit alpha/beta	Family
K [auth Q], Y [auth q]	IPR035206	Proteasome subunit beta 2	Family
L [auth R], Z [auth r]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
L [auth R], Z [auth r]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
L [auth R], Z [auth r]	IPR023333	Proteasome B-type subunit	Family
L [auth R], Z [auth r]	IPR001353	Proteasome, subunit alpha/beta	Family
L [auth R], Z [auth r]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
AA [auth s], M [auth S]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
AA [auth s], M [auth S]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
AA [auth s], M [auth S]	IPR023333	Proteasome B-type subunit	Family
AA [auth s], M [auth S]	IPR001353	Proteasome, subunit alpha/beta	Family
BA [auth t], N [auth T]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
BA [auth t], N [auth T]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
BA [auth t], N [auth T]	IPR023333	Proteasome B-type subunit	Family
BA [auth t], N [auth T]	IPR016295	Proteasome subunit beta 4	Family
BA [auth t], N [auth T]	IPR001353	Proteasome, subunit alpha/beta	Family
CA [auth A]	IPR050221	26S Proteasome Regulatory ATPase	Family
CA [auth A]	IPR003593	AAA+ ATPase domain	Domain
CA [auth A]	IPR003959	ATPase, AAA-type, core	Domain
CA [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
CA [auth A]	IPR048723	26S proteasome regulatory subunit 7-like, OB domain	Domain
CA [auth A]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
CA [auth A]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
CA [auth A]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
DA [auth B]	IPR050221	26S Proteasome Regulatory ATPase	Family
DA [auth B]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
DA [auth B]	IPR032501	Proteasomal ATPase, second OB domain	Domain
DA [auth B]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
DA [auth B]	IPR003593	AAA+ ATPase domain	Domain
DA [auth B]	IPR003959	ATPase, AAA-type, core	Domain
DA [auth B]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
DA [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
FA [auth D]	IPR050221	26S Proteasome Regulatory ATPase	Family
FA [auth D]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
FA [auth D]	IPR032501	Proteasomal ATPase, second OB domain	Domain
FA [auth D]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
FA [auth D]	IPR003593	AAA+ ATPase domain	Domain
FA [auth D]	IPR003959	ATPase, AAA-type, core	Domain
FA [auth D]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
FA [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
GA [auth E]	IPR050221	26S Proteasome Regulatory ATPase	Family
GA [auth E]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
GA [auth E]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
GA [auth E]	IPR003593	AAA+ ATPase domain	Domain
GA [auth E]	IPR003959	ATPase, AAA-type, core	Domain
GA [auth E]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
GA [auth E]	IPR032501	Proteasomal ATPase, second OB domain	Domain
GA [auth E]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
IA [auth V]	IPR013586	26S proteasome regulatory subunit, C-terminal	Domain
IA [auth V]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
IA [auth V]	IPR050756	COP9 signalosome complex subunit 3	Family
IA [auth V]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
IA [auth V]	IPR000717	Proteasome component (PCI) domain	Domain
KA [auth X]	IPR050871	26S Proteasome and COP9 Signalosome Components	Family
KA [auth X]	IPR040780	6S proteasome subunit Rpn6, C-terminal helix domain	Domain
KA [auth X]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
KA [auth X]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
KA [auth X]	IPR040773	26S proteasome regulatory subunit Rpn6, N-terminal	Domain
KA [auth X]	IPR000717	Proteasome component (PCI) domain	Domain
LA [auth Y]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
LA [auth Y]	IPR019585	26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1	Family
LA [auth Y]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
LA [auth Y]	IPR049549	26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix	Domain
LA [auth Y]	IPR000717	Proteasome component (PCI) domain	Domain
LA [auth Y]	IPR045135	26S proteasome regulatory subunit Rpn7, N-terminal	Domain
MA [auth Z]	IPR033858	26S Proteasome non-ATPase regulatory subunit 7/8	Family
MA [auth Z]	IPR024969	EIF3F/CSN6-like, C-terminal	Domain
MA [auth Z]	IPR037518	MPN domain	Domain
MA [auth Z]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
NA [auth a]	IPR054179	PSD13, N-terminal	Domain
NA [auth a]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
NA [auth a]	IPR035298	26S Proteasome non-ATPase regulatory subunit 13	Family
NA [auth a]	IPR000717	Proteasome component (PCI) domain	Domain
OA [auth b]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
OA [auth b]	IPR027040	26S proteasome non-ATPase regulatory subunit 4	Family
OA [auth b]	IPR002035	von Willebrand factor, type A	Domain
OA [auth b]	IPR003903	Ubiquitin interacting motif	Conserved Site
OA [auth b]	IPR049590	PSMD4, RAZUL domain	Domain
PA [auth d]	IPR000717	Proteasome component (PCI) domain	Domain
PA [auth d]	IPR006746	26S proteasome non-ATPase regulatory subunit Rpn12	Family
PA [auth d]	IPR033464	CSN8/PSMD8/EIF3K	Domain
QA [auth e]	IPR007834	DSS1/SEM1	Family
TA [auth c]	IPR056263	26S proteasome regulatory subunit RPN11, C-terminal domain	Domain
TA [auth c]	IPR050242	JAMM/MPN+ metalloenzymes, peptidase M67A	Family
TA [auth c]	IPR037518	MPN domain	Domain
TA [auth c]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
UA [auth f]	IPR041433	26S proteasome non-ATPase regulatory subunit RPN1, C-terminal	Domain
UA [auth f]	IPR016024	Armadillo-type fold	Homologous Superfamily
UA [auth f]	IPR002015	Proteasome/cyclosome repeat	Repeat
UA [auth f]	IPR016643	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit	Family
UA [auth f]	IPR011989	Armadillo-like helical	Homologous Superfamily
UA [auth f]	IPR040892	RPN1, N-terminal	Domain
VA [auth z]	IPR039336	Midnolin	Family
VA [auth z]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
VA [auth z]	IPR000626	Ubiquitin-like domain	Domain
EA [auth C]	IPR050221	26S Proteasome Regulatory ATPase	Family
EA [auth C]	IPR003593	AAA+ ATPase domain	Domain
EA [auth C]	IPR003959	ATPase, AAA-type, core	Domain
EA [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
EA [auth C]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
EA [auth C]	IPR032501	Proteasomal ATPase, second OB domain	Domain
EA [auth C]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
EA [auth C]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
HA [auth F]	IPR050221	26S Proteasome Regulatory ATPase	Family
HA [auth F]	IPR003593	AAA+ ATPase domain	Domain
HA [auth F]	IPR003959	ATPase, AAA-type, core	Domain
HA [auth F]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
HA [auth F]	IPR041569	AAA ATPase, AAA+ lid domain	Domain
HA [auth F]	IPR032501	Proteasomal ATPase, second OB domain	Domain
HA [auth F]	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
HA [auth F]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
JA [auth W]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
JA [auth W]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
JA [auth W]	IPR000717	Proteasome component (PCI) domain	Domain
JA [auth W]	IPR040896	26S proteasome regulatory subunit RPN5, C-terminal domain	Domain
JA [auth W]	IPR040134	26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4	Family
JA [auth W]	IPR054559	PSMD12/CSN4-like, N-terminal	Domain
C [auth I], Q [auth i]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
C [auth I], Q [auth i]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
C [auth I], Q [auth i]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
C [auth I], Q [auth i]	IPR050115	Proteasome subunit alpha	Family
C [auth I], Q [auth i]	IPR023332	Proteasome alpha-type subunit	Family
C [auth I], Q [auth i]	IPR001353	Proteasome, subunit alpha/beta	Family
SA [auth U]	IPR040623	26S proteasome regulatory subunit RPN2, C-terminal	Domain
SA [auth U]	IPR016024	Armadillo-type fold	Homologous Superfamily
SA [auth U]	IPR002015	Proteasome/cyclosome repeat	Repeat
SA [auth U]	IPR011989	Armadillo-like helical	Homologous Superfamily
SA [auth U]	IPR048570	26S proteasome non-ATPase regulatory subunit 1/RPN2, N-terminal domain	Domain
SA [auth U]	IPR016642	26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit	Family
I [auth O], W [auth o]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
I [auth O], W [auth o]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
I [auth O], W [auth o]	IPR024689	Proteasome beta subunit, C-terminal	Domain
I [auth O], W [auth o]	IPR023333	Proteasome B-type subunit	Family
I [auth O], W [auth o]	IPR001353	Proteasome, subunit alpha/beta	Family
I [auth O], W [auth o]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth G], O [auth g]	Pharos: P60900	HIV infectious disease myocardial infarction HIV Coinfection psoriasis
B [auth H], P [auth h]	Pharos: P25787	osteoporosis heart disease breast cancer malignant mesothelioma Osteoporosis, Senile psoriasis colorectal cancer ovarian cancer
D [auth J], R [auth j]	Pharos: O14818	breast cancer lung cancer pancreatic intraductal papillary-mucinous carcinoma glioblastoma medulloblastoma plasma cell myeloma intellectual disability ovarian cancer Sjogren syndrome
E [auth K], S [auth k]	Pharos: P28066	HIV infectious disease osteoporosis non-small cell lung carcinoma Osteoporosis, Age-Related ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Alzheimer disease pilocytic astrocytoma cystic fibrosis primitive neuroectodermal tumor fatty liver disease tuberculosis glioblastoma lung cancer malignant glioma HIV infectious disease osteoporosis non-small cell lung carcinoma Osteoporosis, Age-Related ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Alzheimer disease pilocytic astrocytoma cystic fibrosis primitive neuroectodermal tumor fatty liver disease tuberculosis glioblastoma lung cancer malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor pituitary cancer diabetes mellitus psoriasis gastric cancer hepatocellular carcinoma invasive ductal breast carcinoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma malignant ependymoma
F [auth L], T [auth l]	Pharos: P25786	mantle cell lymphoma plasma cell myeloma Systemic AL amyloidosis
G [auth M], U [auth m]	Pharos: P25788	attention deficit hyperactivity disorder, inattentive type lymphoplasmacytic lymphoma pancreatic ductal adenocarcinoma Sjogren syndrome dermatomyositis osteosarcoma plasma cell myeloma heart disease ovarian cancer psoriasis
H [auth N], V [auth n]	Pharos: P28072	attention deficit hyperactivity disorder, inattentive type ovarian cancer psoriasis brain aneurysm pancreatic ductal adenocarcinoma Sjogren syndrome lung cancer plasma cell myeloma systemic lupus erythematosus
J [auth P], X [auth p]	Pharos: P49720	chronic obstructive pulmonary disease lymphoplasmacytic lymphoma diabetes mellitus ovarian cancer glioblastoma plasma cell myeloma
K [auth Q], Y [auth q]	Pharos: P49721	urinary bladder cancer atypical teratoid rhabdoid tumor glioblastoma lung carcinoma osteosarcoma Sjogren syndrome breast cancer invasive ductal breast carcinoma malignant mesothelioma ovarian cancer Systemic AL amyloidosis urinary bladder neoplasm diabetes mellitus large cell medulloblastoma mantle cell lymphoma urinary bladder cancer atypical teratoid rhabdoid tumor glioblastoma lung carcinoma osteosarcoma Sjogren syndrome breast cancer invasive ductal breast carcinoma malignant mesothelioma ovarian cancer Systemic AL amyloidosis urinary bladder neoplasm diabetes mellitus large cell medulloblastoma mantle cell lymphoma plasma cell myeloma systemic lupus erythematosus
L [auth R], Z [auth r]	Pharos: P28074	plasma cell myeloma acute lymphoblastic leukemia diabetes mellitus mantle cell lymphoma ovarian cancer Relapse multiple myeloma B-cell acute lymphoblastic leukemia hypertensive disorder medulloblastoma coronary artery disease lung cancer myocardial ischemia psoriasis
AA [auth s], M [auth S]	Pharos: P20618	acute coronary syndrome peripheral neuropathy plasma cell myeloma peripheral nervous system disease lymphoplasmacytic lymphoma osteoarthritis ovarian cancer dermatomyositis malignant colon neoplasm osteoarthritis susceptibility 1 pancreatic ductal adenocarcinoma glioblastoma mantle cell lymphoma Osteoarthrosis Deformans
BA [auth t], N [auth T]	Pharos: P28070	HIV infectious disease HIV Coinfection lymphoplasmacytic lymphoma plasma cell myeloma Sjogren syndrome major depressive disorder proteasome-associated autoinflammatory syndrome 3 lung cancer ovarian cancer psoriasis
CA [auth A]	Pharos: P35998	dermatomyositis osteosarcoma plasma cell myeloma lung cancer ovarian cancer psoriasis malignant mesothelioma pancreatic ductal adenocarcinoma
FA [auth D]	Pharos: P43686	astrocytic tumor Hodgkins lymphoma diabetes mellitus osteosarcoma glioblastoma ovarian cancer
IA [auth V]	Pharos: O43242	HIV infectious disease acute lymphoblastic leukemia cervical cancer dermatomyositis lung adenocarcinoma ulcerative colitis allergic rhinitis chronic obstructive pulmonary disease HIV Coinfection rheumatoid arthritis breast carcinoma Crohn disease systemic sclerosis
KA [auth X]	Pharos: O00231	attention deficit hyperactivity disorder, inattentive type glioblastoma malignant ependymoma osteosarcoma plasma cell myeloma atypical teratoid rhabdoid tumor lung adenocarcinoma malignant glioma ovarian cancer subependymal giant cell astrocytoma breast cancer lung cancer malignant mesothelioma Pick disease tuberculosis
LA [auth Y]	Pharos: Q15008	HIV infectious disease type 2 diabetes mellitus breast carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma Diabetes Mellitus, Non-Insulin-Dependent malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm maturity-onset diabetes of the young pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
MA [auth Z]	Pharos: P51665	lung cancer psoriasis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm
NA [auth a]	Pharos: Q9UNM6	HIV infectious disease benign prostatic hyperplasia heart disease osteosarcoma psoriasis brain aneurysm HIV Coinfection ovarian cancer uterine corpus leiomyoma Hashimoto thyroiditis plasma cell myeloma
OA [auth b]	Pharos: P55036	heart disease ovarian cancer lung cancer plasma cell myeloma myocardial infarction
PA [auth d]	Pharos: P48556	HIV infectious disease glioblastoma ovarian cancer Sjogren syndrome HIV Coinfection pancreatic ductal adenocarcinoma plasma cell myeloma
QA [auth e]	Pharos: P60896	squamous cell carcinoma bone disease non-small cell lung carcinoma split hand-foot malformation lung cancer osteoporosis medulloblastoma pneumonia subependymal giant cell astrocytoma
TA [auth c]	Pharos: O00487	breast cancer lung cancer ovarian cancer endogenous depression lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma medulloblastoma plasma cell myeloma
UA [auth f]	Pharos: Q13200	breast cancer ovarian cancer lung cancer psoriasis non-small cell lung carcinoma
VA [auth z]	Pharos: Q504T8	astrocytic tumor gastric carcinoma medulloblastoma osteosarcoma primitive neuroectodermal tumor colorectal cancer glioblastoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma rheumatoid arthritis diabetes mellitus interstitial lung disease oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm
EA [auth C]	Pharos: P62195	Stevens-Johnson syndrome HIV infectious disease colorectal cancer plasma cell myeloma toxic epidermal necrolysis Drug-Induced Stevens Johnson Syndrome ovarian cancer
HA [auth F]	Pharos: P17980	HIV infectious disease cataract HIV Coinfection lung cancer ovarian cancer prostate carcinoma cerebrovascular disorder metabolic syndrome X peripheral neuropathy subependymal giant cell astrocytoma endogenous depression hypertensive disorder open-angle glaucoma plasma cell myeloma
JA [auth W]	Pharos: O00232	contact dermatitis atypical teratoid rhabdoid tumor intellectual disability non-small cell lung carcinoma pancreatic ductal adenocarcinoma psoriasis invasive ductal breast carcinoma osteosarcoma Parkinson disease Stankiewicz-Isidor syndrome Contact hypersensitivity lung cancer ovarian cancer plasma cell myeloma
C [auth I], Q [auth i]	Pharos: P25789	Mammary Neoplasms, Experimental sarcomatoid carcinoma adult acute respiratory distress syndrome carcinoma HIV infectious disease liver cancer lung carcinoma mammary neoplasms, animal ovarian cancer polycystic ovary syndrome abdominal aortic aneurysm small cell lung carcinoma bipolar disorder bronchitis chronic obstructive pulmonary disease Mammary Neoplasms, Experimental sarcomatoid carcinoma adult acute respiratory distress syndrome carcinoma HIV infectious disease liver cancer lung carcinoma mammary neoplasms, animal ovarian cancer polycystic ovary syndrome abdominal aortic aneurysm small cell lung carcinoma bipolar disorder bronchitis chronic obstructive pulmonary disease liver neoplasm lymphoplasmacytic lymphoma peripheral arterial disease squamous cell lung carcinoma anorexia nervosa brain aneurysm dental caries lung adenocarcinoma nicotine dependence plasma cell myeloma Sjogren syndrome undifferentiated carcinoma autism spectrum disorder breast cancer dermatomyositis
SA [auth U]	Pharos: Q99460	dermatomyositis osteosarcoma psoriasis lung adenocarcinoma ovarian cancer lung cancer pancreatic intraductal papillary-mucinous neoplasm
I [auth O], W [auth o]	Pharos: Q99436	atrial fibrillation allergic rhinitis hepatocellular carcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease plasma cell myeloma astrocytic tumor hypothyroidism oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy vitiligo lymphoplasmacytic lymphoma ovarian cancer atrial fibrillation allergic rhinitis hepatocellular carcinoma malignant ependymoma pancreatic intraductal papillary-mucinous carcinoma peripheral nervous system disease plasma cell myeloma astrocytic tumor hypothyroidism oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm peripheral neuropathy vitiligo lymphoplasmacytic lymphoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Pick disease