9O6T | pdb_00009o6t

Structure of the human prohibitin complex in the open state

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	PF01145	SPFH domain / Band 7 family (Band_7)	SPFH domain / Band 7 family	This family has been called SPFH [1], Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.	Domain
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	PF01145	SPFH domain / Band 7 family (Band_7)	SPFH domain / Band 7 family	This family has been called SPFH [1], Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	Prohibitin-2	binding sphingolipid binding lipid binding amide binding identical protein binding protein binding protein heterodimerization activity protein dimerization activity protein homodimerization activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear estrogen receptor binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress regulation of protein stability biological regulation regulation of biological quality protein stabilization response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus cellular process regulation of cell cycle phase transition regulation of cellular process positive regulation of biological process cell cycle phase transition exit from mitosis mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of exit from mitosis positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle positive regulation of cellular process cell cycle process regulation of biological process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of cell cycle regulation of mitotic cell cycle phase transition nuclear division organelle organization mitotic cell cycle process positive regulation of cell cycle phase transition regulation of exit from mitosis mitotic cell cycle phase transition positive regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process multicellular organismal process immune system process B cell activation cell activation lymphocyte activation leukocyte activation positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway response to biotic stimulus intracellular signal transduction cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus RIG-I signaling pathway regulation of response to stimulus defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response response to external biotic stimulus positive regulation of innate immune response defense response defense response to symbiont chromosome organization sister chromatid cohesion response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to retinoic acid cellular response to lipid protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport cell migration cell motility regulation of localization regulation of catalytic activity monoatomic ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of transporter activity monoatomic cation transmembrane transport regulation of cytochrome-c oxidase activity monoatomic ion transport monoatomic cation transport regulation of monoatomic ion transmembrane transporter activity regulation of proton transport regulation of transport proton transmembrane transport regulation of monoatomic ion transport regulation of oxidoreductase activity inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport regulation of immune effector process immunoglobulin production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of immune effector process positive regulation of macromolecule metabolic process positive regulation of immunoglobulin production production of molecular mediator of immune response immune effector process regulation of immunoglobulin production positive regulation of gene expression positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response hormone-mediated signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus estrogen receptor signaling pathway nuclear receptor-mediated signaling pathway negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of intracellular steroid hormone receptor signaling pathway regulation of intracellular signal transduction regulation of intracellular steroid hormone receptor signaling pathway regulation of intracellular estrogen receptor signaling pathway negative regulation of cellular process negative regulation of intracellular estrogen receptor signaling pathway regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of cell communication branching involved in mammary gland duct morphogenesis development of secondary female sexual characteristics mammary gland morphogenesis reproductive process mammary gland development branching morphogenesis of an epithelial tube gland development mammary gland branching involved in thelarche developmental process involved in reproduction multicellular organism development tube morphogenesis gland morphogenesis anatomical structure development animal organ morphogenesis thelarche epithelial tube morphogenesis development of secondary sexual characteristics developmental process epithelium development tube development animal organ development morphogenesis of an epithelium tissue development mammary gland duct morphogenesis tissue morphogenesis anatomical structure morphogenesis mammary gland epithelium development morphogenesis of a branching structure morphogenesis of a branching epithelium regulation of developmental process regulation of branching involved in mammary gland duct morphogenesis regulation of morphogenesis of an epithelium regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of DNA-binding transcription factor activity negative regulation of molecular function positive regulation of cell communication positive regulation of signal transduction positive regulation of ERK1 and ERK2 cascade intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death negative regulation of mammary gland epithelial cell proliferation epithelial cell proliferation negative regulation of cell population proliferation cell population proliferation regulation of mammary gland epithelial cell proliferation regulation of cell population proliferation regulation of epithelial cell proliferation negative regulation of multicellular organismal process negative regulation of epithelial cell proliferation mammary gland epithelial cell proliferation phosphatidylglycerol metabolic process regulation of lipid metabolic process glycerophospholipid metabolic process regulation of phospholipid metabolic process cardiolipin metabolic process phospholipid metabolic process regulation of cardiolipin metabolic process organophosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process glycerolipid metabolic process regulation of phosphorus metabolic process phosphorus metabolic process lipid metabolic process defense response to virus antiviral innate immune response response to virus regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition positive regulation of cell cycle G1/S phase transition mitochondrion organization mitophagy catabolic process macroautophagy autophagy autophagy of mitochondrion process utilizing autophagic mechanism mammary gland lobule development mammary gland alveolus development	presynapse cellular anatomical structure synapse cell junction presynaptic active zone intracellular anatomical structure cytoplasm glutamatergic synapse membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle presynapse cellular anatomical structure synapse cell junction presynaptic active zone intracellular anatomical structure cytoplasm glutamatergic synapse membrane-bounded organelle mitochondrial membrane mitochondrion membrane organelle outer membrane intracellular membrane-bounded organelle intracellular organelle organelle envelope bounding membrane of organelle organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane axon cell projection neuron projection plasma membrane bounded cell projection organelle inner membrane mitochondrial inner membrane nucleus membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear lumen nuclear matrix cell surface cell periphery plasma membrane protein-containing complex GABA-ergic synapse postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse mitochondrial protein-containing complex membrane protein complex mitochondrial prohibitin complex inner mitochondrial membrane protein complex
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	Prohibitin 1	histone deacetylase binding protein binding binding enzyme binding opsonin binding complement component C3b binding complement binding complement component C3a binding proteinase activated receptor binding signaling receptor binding G protein-coupled receptor binding protein heterodimerization activity protein dimerization activity transcription corepressor activity histone deacetylase binding protein binding binding enzyme binding opsonin binding complement component C3b binding complement binding complement component C3a binding proteinase activated receptor binding signaling receptor binding G protein-coupled receptor binding protein heterodimerization activity protein dimerization activity transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction response to stimulus signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction response to stimulus signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular process signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of cellular process positive regulation of signaling regulation of protein stability regulation of biological quality protein stabilization regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction epigenetic regulation of gene expression cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis multicellular organismal process immune system process B cell activation cell activation lymphocyte activation leukocyte activation positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway response to biotic stimulus intracellular signal transduction immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus RIG-I signaling pathway defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus intracellular receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response response to external biotic stimulus positive regulation of innate immune response defense response defense response to symbiont neuron apoptotic process positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process positive regulation of neuron apoptotic process programmed cell death regulation of neuron apoptotic process regulation of growth regulation of cellular component organization negative regulation of biological process growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth negative regulation of cellular process negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade regulation of humoral immune response regulation of immune effector process humoral immune response immune effector process complement activation positive regulation of humoral immune response positive regulation of complement activation positive regulation of immune effector process regulation of complement activation primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process DNA biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of DNA-templated transcription response to peptide response to interleukin-6 cellular response to interleukin-6 response to chemical response to cytokine cellular response to cytokine stimulus immunoglobulin production positive regulation of immunoglobulin production production of molecular mediator of immune response regulation of immunoglobulin production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation response to lipid progesterone receptor signaling pathway hormone-mediated signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus cellular response to chemical stimulus cellular response to lipid nuclear receptor-mediated signaling pathway catabolic process macromolecule catabolic process negative regulation of protein catabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of protein metabolic process negative regulation of metabolic process protein catabolic process regulation of catabolic process regulation of protein catabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process developmental process cellular developmental process ossification cell differentiation osteoblast differentiation positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade positive regulation of intracellular signal transduction adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains adaptive immune response T-helper 17 type immune response regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of intracellular steroid hormone receptor signaling pathway regulation of intracellular steroid hormone receptor signaling pathway nuclear receptor-mediated corticosteroid signaling pathway negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway regulation of nuclear receptor-mediated glucocorticoid signaling pathway nuclear receptor-mediated glucocorticoid signaling pathway negative regulation of transcription by competitive promoter binding defense response to virus antiviral innate immune response response to virus modulation by host of viral RNA genome replication host-mediated perturbation of symbiont process modulation by host of viral genome replication modulation by host of viral process viral genome replication viral RNA genome replication modulation of process of another organism negative regulation of cell population proliferation positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction cytokine production regulation of cytokine production regulation of multicellular organismal process interleukin-17 production regulation of interleukin-17 production positive regulation of multicellular organismal process positive regulation of interleukin-17 production positive regulation of cytokine production androgen receptor signaling pathway regulation of androgen receptor signaling pathway negative regulation of androgen receptor signaling pathway organelle organization mitochondrion organization	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm intracellular organelle cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm intracellular organelle mitochondrion intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane cell surface cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen early endosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle mitochondrial protein-containing complex protein-containing complex membrane protein complex mitochondrial prohibitin complex inner mitochondrial membrane protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR036013	Band 7/SPFH domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR001107	Band 7 domain	Domain
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	IPR000163	Prohibitin	Family
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR036013	Band 7/SPFH domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR001107	Band 7 domain	Domain
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	IPR000163	Prohibitin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G, I A, C, E, G, I, K, M, O, Q, S, U, W	Pharos: Q99623	colorectal cancer lung cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia heart disease medulloblastoma plasma cell myeloma large cell medulloblastoma ovarian cancer
B, D, F, H, J B, D, F, H, J, L, N, P, R, T, V, X	Pharos: P35232	adenocarcinoma Mammary Neoplasms, Experimental breast carcinoma tubular adenocarcinoma sarcomatoid carcinoma esophageal cancer granular cell carcinoma carcinoma schizophrenia gastric cancer heart disease hereditary diffuse gastric adenocarcinoma lung cancer allergic rhinitis asthma adenocarcinoma Mammary Neoplasms, Experimental breast carcinoma tubular adenocarcinoma sarcomatoid carcinoma esophageal cancer granular cell carcinoma carcinoma schizophrenia gastric cancer heart disease hereditary diffuse gastric adenocarcinoma lung cancer allergic rhinitis asthma nasopharyngeal carcinoma plasma cell myeloma prostate carcinoma cribriform carcinoma of breast drug psychosis gastric neoplasm hepatocellular carcinoma atopic eczema neoplasm of esophagus cancer precancerous condition psoriasis undifferentiated carcinoma hereditary breast carcinoma lung adenocarcinoma mammary neoplasms, animal myocardial infarction breast cancer ovarian cancer cribriform carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.