210

PAMIDRONATE

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is present as a standalone ligand in 9 entries

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Chemical Component Summary
Name	PAMIDRONATE
Synonyms	(3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID
Identifiers	(3-amino-1-hydroxy-1-phosphono-propyl)phosphonic acid
Formula	C₃ H₁₁ N O₇ P₂
Molecular Weight	235.069
Type	NON-POLYMER
Isomeric SMILES	C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
InChI	InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
InChIKey	WRUUGTRCQOWXEG-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	24
Chiral Atom Count	0
Bond Count	23
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00282 ?
Name	Pamidronic acid
Groups	approved
Description	Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular.[A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]
Synonyms	Acide pamidronique Pamidronic acid Pamidronate Acidum pamidronicum Pamidronate Disodium Acido pamidronico
Brand Names	Pamidronate Disodium Pamidronate Disodium Omega 9 mg/ml Aredia Aredia 90mg Val-pamidronate Disodium PMS-pamidronate Aredia Liq Inj 3mg/ml Pamidronate Disodium Omega 3 mg/ml Pamidronate Disodium Omega 6 mg/ml Aredia 30mg Pamidronate Disodium for Injection
Indication	Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.[L13838]
Categories	Agents Causing Muscle Toxicity Antineoplastic Agents Bisphosphonates Bone Density Conservation Agents Drugs Affecting Bone Structure and Mineralization Drugs for Treatment of Bone Diseases Musculo-Skeletal System Nephrotoxic agents Organophosphonates Organophosphorus Compounds
ATC-Code	M05BA03
CAS number	40391-99-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Farnesyl pyrophosphate synthase	MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCW...	unknown	inhibitor
Hydroxylapatite	-	unknown	antagonist
Geranylgeranyl pyrophosphate synthase	MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIII...	unknown	inhibitor
Caspase-3	MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIII...	unknown	activator
Caspase-9	MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGS...	unknown	activator

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682