4DY

(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide

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is present as a standalone ligand in 7 entries

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Chemical Component Summary
Name	(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
Synonyms	Capsaicin; 8-Methyl-N-vanillyl-trans-6-nonenamide; NGX-4010
Identifiers	(E)-N-[(3-methoxy-4-oxidanyl-phenyl)methyl]-8-methyl-non-6-enamide
Formula	C₁₈ H₂₇ N O₃
Molecular Weight	305.412
Type	NON-POLYMER
Isomeric SMILES	CC(C)/C=C/CCCCC(=O)NCc1ccc(c(c1)OC)O
InChI	InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChIKey	YKPUWZUDDOIDPM-SOFGYWHQSA-N

Chemical Details
Formal Charge	0
Atom Count	49
Chiral Atom Count	0
Bond Count	49
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB06774 ?
Name	Capsaicin
Groups	approved
Description	Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
Synonyms	Capsaicina Isodecenoic acid vanillylamide (E)-8-Methyl-N-vanillyl-6-nonenamide Capsaicin trans-8-Methyl-N-vanillyl-6-nonenamide
Brand Names	CareALL Arthritis and Muscle Melt Pain Away Cajun Hot Ice Muscle and Joint Pain Rub Nufabrx Medicine Infused Ankle Sleeve Capsodan Cream Antiphlogistine Rub A-535 Capsaicin Gel Equi-block Dt Formula NuDroxiPAK Transderm-iQ Moisturizing Glucosamine Brand RockSauce FIERY HOT PAIN RELIEF Arth Arrest Sure Relief SR Relief Sinelee Nufabrx Wrist Sleeve Flex-OL IRxMyoRub Theragen Nufabrx Calf Sleeve Soothe New Terocin Nufabrx Ankle Sleeve Sinsinpas Hot Large Capment Zostrix Hot and Cold Therapy System Family Care Thera Flex Pain Rezil CANNABIN PLUS Warming Pain Relief Captracin Nufabrx Medicine Infused Socks Arthricare for Women Multi-action Corisin Arthritis Pain Relief PainKoolers Topical Analgesic Zostrix High Potency Foot Pain Relief KASEHA Pain Relieving Gel Mac Aleveer Patch Sherman and Clark Pain Relieving Capsimide Capzasin HP Arthritis Pain Relief Eagle Qutenza Arthritic Pain Relief Simanix Diclopak Kapsin External Analgesic Medicated Compression Sock Medi-derm / L With Lidocaine Rx NaproPax Emu Essentials Brand Pain Relieving Exoten-C Synovium Pain Relieving Gel Capsaicin Forte Cream QC Arthritis Pain Relief Hong Hoa Pain Relieving Parche Leon Milagroso Dual Action Sure Result SR Relief Frankie Avalons ZERO PAIN Original Formula Roll-On Maximum Strength PAIN RELIEVER NuDroxiPAK DSDR-50 Pure Pain Relief Invisible Pain Family Care Arthritis Pain Relief Kerasal NeuroCream Raging Kakapo Pain Relieve Toplast Cool and Hot Menthol 4percent plus Capsaicin 0.025percent Migryl Flanax Liniment Unit Dose Display Kapzin DC MedWorx Med O-3 Bio- Flexin Nufabrx Hand/Wrist Sleeve CVS Roll-On Coralite Medicated Heat Releevia MC Kapsin Parche Leon Milagroso FYZICAL SPORTS Pain Relief Arth RX Topical Analgesic Oprava BIO-MEGA Heat Therapy Relyyt Capsaicin Regular Cream Arthritazin Pain Relieving EZ Capsaicin Heat Fors Pain Relief Capsaicin Mild Cream Dr. Harveys Herbal Motion Pain Formula SprayPain Away Dolor-parche With Lidocaine-RX Minted Leaf Heat Therapy Relief Roll-On Dr Iyers MyoRub Good Neighbor Capsaicin Heat Patch for Back Capsaicin Cream Red Hot Penetrex(r) Arthritis Pain Relief Megrix Pallerix SmartRx Gaba-V Kit Dfs 1.5%/ms 25%/menth 6%/cap 0.025% Pak Medi-patch With Lidocaine Rx Solaice Kentwool SensationWool with Nufabrx 2-Count HEAT PATCHES Kool Heat Pain Therapy Bio-Sorb Diclovix CM Pure Relief Trubrexa Wellness Products VictoRx Capsaicin Arthritis Pain Relief Cream DCH Arthritis Pain Relief Roll-On Nopiate Topical Pain Relief FYZICAL SPORTS Pain Relief 2 MILD Pain Relieving Gel-Patch Neuriterx 0.05% 1st Medxpatch With Lidocaine 4%-rx Douleurin Topical Pain Relief Xyphex Biofrequency Chip Remaxazon External Patch NuDroxiPAK N-500 AVON HeXashield Arthritis Pain Relief Cream Capsaisin Overtime Soothee Patch 1st Medxpatch With Lidocaine 4% Rite Aid Capsicum Hot Zostrix Joint and Arthritis Pain Relief Dr.'s Cream Omega 3 Heat Therapy Zostrix Original Strength Nufabrx Grey Polka Dot Sock Toplast Cool and Hot Menthol 1.25percent plus Capsaicin 0.025percent NuDiclo TabPak Dr Demand Relief Pain Relief Flexipak Miracle Plus Neck and Shoulder Pain Relief PainKoolers Anodynz Biofrequency Chip DFS 75mg DR/MS 25%/MENTH 6%/CAP 0.025% PAK Capsaicin Heat Patches Back and Large Areas Pennsaicin Ultracin CVS Medicated Heat 1 ct Zang Hong Hua Pain Relieving NuDroxicin Medicated Pain Relief Hot FYZICAL SPORTS Pain Relief 1-COOL Perform Atomic Heat PainBloc24 FlexxSonic Pain Relief Awaye Rock Sauce Aflexeryl-MC Sinsinpas Hot Neuriterx Ziclopro Capsaicin Rub A535 Capsaicin NuDroxiPAK I-800 My Omega Heat Therapy Born Again Super Pain Relieving Lotion Zostrix Hp Hot Pain Relieving Astrapharm Chilli Brand External Medicated Outdoor Hands Arthur Itis Cream Menthacin Lotion NuDroxiPAK E-400 Pain Relieving Roll-On Better Nature Pain Relief BalmX CVS Capsaicin FourPainRX Arthritis Pain Reliever Arthricare for Women Extra Moisturizing Doloracin/l Rx With Lidocaine K2c Rocksauce Ice Rocksauce Fire Overtime-X Astrapharm Chilli Brand Rugby Arthritis Pain Relieving Topical Analgesic CMX Topical Pain AmeriPatch IRxAmigra Reliever Screamin Hot Toast Ultra Strength Pain Relief MaC Patch Inavix Ageranium Patch Genorthix Pain Relieving Roll On Alegenix Biofrequency Chip Arthricare for Women Quick Drying External Analgesic Equate Capsaicin Pain Relieving Glacierix Coralite Topical Analgesic Capsaicin Heat DINGTAI PHARMATopical Analgesic Nufabrx Lower Leg Sleeve XL/XXL bB Medicated Pain Relieving Oil Capsaicin Hot Patches Medi-derm Rx Nufabrx Lower Leg Sleeve Pain Relief Patch N-LABS SOLAR MAX Topical Analgesic Heet Liniment Liq Castiva Warming PainMD Max Moor Balm - Crm Guardania Pain Menthocin Patch with Lidocaine - Strong PainBloc Joint Maintenance Compliance Kit Medi-sulting Topical Pain Relief Megrix OTC HURT BLOCKER PRO Pain Relief Qroxin Patch Weh-Weh Natural Pain relief oil Australian Dream Power 4 Muscle and Joint Pain Relief Cream Topical Pain Relief Tianhe Gutong Tiegao (in Polyisobutylene Carrier) Capsinac ZENSEZONE Arthmed Temporary Pain Relief Cream Capsaicin Heat Patches Pain Relief Renovo Menthol 4.5% Capsaicin 0.0225% LaboFlex Cool and Hot Menthol 1.25 percent Capsaicin 0.025 percent Complete hemp Arthritazin Pain Relieving Overtime-HMP LexiCaps Medrox-Rx Capzix Hurt Blocker Pro Assured Pain Relief Hot Menthol Nuvira Patch Capsaicin Topical Analgesic RETADOLOR Pain Relief BioMega Heat Pain Therapy Doloracin Rx Menthocin Patch with Lidocaine Neurodexx Mentholatum Ironman Terocin CMC Pain Relieving DICLAREAL TOPICAL kit Arthritis Extra Strength Roll-ON Lotion Coralite Pain Relief CyclobenzaprinePax Nufabrx Knee Sleeve Aspercreme Warming Hot Spot Point Relief NuDiclo SoluPak Mega Patch CVS Capsaicin arthritis pain relief Better Nature Pain Relief Cream Ultra Therapy Pain Relief Compression Sock Kessler Family Wellness Tianhe Zhuifeng Gao SumaChip AnodyneRx Hot spot point relief Nufabrx Back Wrap Iclofenac CP Pain Away Nufabrx Ankle Sock BRONSON SOOTHE Pain Relief LONOL Forte Gel LaBella Linimento Obrero Sure Result DSS Premium Pak FlexePax InstaSoothe Pain Relief Levatio Patch Satohap Cool and Hot Pads LBri Super Aloe Stop The Pain Nexalgia Releevia Atomic Balm VANTELIN HOT PAIN RELIEVING Gel Patch Large Lidopro Fatazen Sweat Enhance Hot Ziclocin Capzasin-P Creme - 0.025% Capzasin Quick Relief Tianhe Gutong Tiegao Zostrix Diabetic Joint and Arthritis Pain Relief Anodynz Migryl Biofrequency Chip Parche Leon Ziks Arthritis Pain Relief Blue Ice Pain Relieving Therapy Pain Capzasin No Mess Applicator Walgreens Arthritis Pain Relief Capsaicin Analgesic Nufabrx Neck Wrap Nufabrx Arm Sleeve NuDroxiPAK M-15 Adazin Leader Capsaicin PureKana Pure Relief Penetrating Pain Relief NuDroxiPAK DSDR-75 Pallerix OTC BIOfrequency Chip CapsFenac Pak Coralite Pain Relief Hot Capsaicin External Analgesic Neuritrx MINTED LEAF Heat Therapy Relief Roll On Capxib Alivio Offense Player Sports Dusel Warm Arthritis Dead Sea Salt Therapy MINTED LEAF Heat Therapy Roll-On with Capsaicin and CBD Capsicum Patch AthletesGel Capsaicin Pain Relief Omega 3 Wasabi Rub MenCaps Rotex Lido-RX 4.1 Transanosil Menthozen Rugby Capsaicin External Analgesic Paraid Hot Capsicum True Pain Relief Plus Assured Pain Relief Hot Patch NaproxenPax Chill Pain Away Medi-derm Topical Pain Relief Coralite Muscle and Joint Pain Relief Ameri Patch Yunnan Baiyao Arthritis Pain Relief Good Neighbor Pharmacy Arthritis Pain Relief Renovo Lido5 Pain Relief Cream Extra Strength Solstice Capsaicin Patch Hot Cvs Capsaicin Flanax Liniment Zostrix Foot Pain Relief Littles All Natural Arthritic Pain Relief Silvera Pain Relief Patch Allevess BLUE SPRING Foot and Leg Comfort Cream with Pain Relief Revlex Arthritis Pain Relief Arthritis Pain Relief Capzasin P Arthritis Pain Relief Walgreens Capsaicin Hot Menthol, Capsaicin Campo pharma Muscle hot Pain Relief Roll On Kanjo Natural Pain relief oil PainKoolers Topical Analgesic Patch Red hot Capsiderm VitaCin Arthmed Topical Analgesic LCDO. ORLANDO RIVERA ARTHRITIS Topical Analgesic Reliaderm Limencin Pain Relieving Capsaicin 0.075 Percent Transderm-IQ A2a Arthritis Flanax Fast Arthritis Aid Pain Relieving Dyninex Power Pain Relief Stick Pain Relief Hot Patch Xoten-C CareOne Arthritis Pain Relief Menthacin - Cream Dr. OH BALM Reme D Wellness Products J-FLEX Extra Strength Pain Reliever EMU THERAPY Red Hot Pepper Pain Relief Cream Rugby Capsaicin Cream LivRelief Pain Relief Cannavera Pain Relief Offense Player Arthritis Pain VANTELIN HOT PAIN RELIEVING Gel Patch Medrox DicloHeal-60 Diclofex DC Overtime-hmp Gellert Joint Care LABOFLEX Cool and Hot Menthol 1.25 percent Capsaicin 0.025 percent LidoPro Benejoint Muscular Balm Medicated Heat NuDroxicin pain relief Roll-On NobleAid CapsAid Nufabrx Diabetic Sock Good Neighbor Pharmacy Capsaicin Triple Action Arthritis Jupiter Pain Patch Menthozen Hydrogel Toplast Cool and Hot Menthol 5percent plus Capsaicin 0.025percent Neuvaxin Patch Hot Pain Relief Medi-derm / L With Lidocaine Meijer Capsaicin Diclosiacin Antiphlogistine Rub A-535 Capsaicin Liquid WellPatch Warming Pain Relief Diclosaicin Toplast Hot Capsaicin 0.025percent Satogesic Hot Nuvira Apanol Linimento Obrero Preferred Plus Arthritis Cream Capsaicin 0.1 Percent Rematex Ultimate Topical Pain Relief Patch Bioaches Capsaicin HP Arthritis Pain Relief Nufabrx Lower Leg Sleeve M/L Topical Pain Relief Rx Frankie Avalons Zero Pain Roll On Trans-D Painazin CP CopperFixx Nufabrx Lower Leg Sleeve XS/S MediRelief Hot Medi-patch With Lidocaine WellPatch Capsaicin Pain Relief Aspercreme Warming Patch Nufabrx Foot/Ankle Sleeve Miracle Plus Overnight Pain Relieving Terphouse Theragen HP Nufabrx Compression Sock BioMega Menthozen Cream Aspercreme Warming No Mess Fesi Astronic Mendex Hempvana Ultra Strength Pain Relief Cream - Deep Heat Pain Relief Dendracin Neurodendraxcin Earths Care Arthritis Leader Capsaicin Pain Relief Cream Alivio Medicated Pain Zostrix Foot Pain Relief Maximum Strength Capsaicin Cream 0.025% Menthozen Hydrogel Patch beeRX Muscle and Joint Pain Relief Soothanol X2 Therapatch Warm Capsaicin No-Fuss Applicator
Indication	The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
Categories	Alkaloids Alkenes Amides Analgesics Anesthetics Anesthetics, Local Antipruritics Basic Lotions and Liniments Benzene Derivatives Capsaicin and Similar Agents Cholinesterase Inhibitors Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Lipids Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Peripheral Nervous System Agents Phenols Polyunsaturated Alkamides Sensory System Agents Solanaceous Alkaloids Topical Products for Joint and Muscular Pain TRPV1 Channel Agonists
ATC-Code	M02AB01 N01BX04
CAS number	404-86-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Transient receptor potential cation channel subfamily V member 1	MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...	unknown	agonist,regulator
Prohibitin-2	MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAI...	unknown
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	inhibitor
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Myeloperoxidase	MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAA...	unknown	inhibitor
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate,inducer
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	substrate
Amine oxidase [flavin-containing] A	MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGG...	unknown	inhibitor
Dopamine beta-hydroxylase	MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYH...	unknown	inhibitor
Glutamine synthetase	MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSE...	unknown	inducer
Cholinesterase	MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFG...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682