7LD

(8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide

Find entries where: 7LD

is present as a standalone ligand in 9 entries

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Chemical Component Summary
Name	(8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide
Synonyms	Lysergic acid diethylamide
Identifiers	(6~{a}~{R},9~{R})-~{N},~{N}-diethyl-7-methyl-6,6~{a},8,9-tetrahydro-4~{H}-indolo[4,3-fg]quinoline-9-carboxamide
Formula	C₂₀ H₂₅ N₃ O
Molecular Weight	323.432
Type	NON-POLYMER
Isomeric SMILES	CCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4c3c(ccc4)C2=C1)C
InChI	InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1
InChIKey	VAYOSLLFUXYJDT-RDTXWAMCSA-N

Chemical Details
Formal Charge	0
Atom Count	49
Chiral Atom Count	2
Bond Count	52
Aromatic Bond Count	10

Drug Info: DrugBank

DrugBank ID	DB04829 ?
Name	Lysergic acid diethylamide
Groups	illicit withdrawn investigational
Description	Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action of LSD on brain chemistry, and varies according to the susceptibility of the individual to the disorder. Many emotionally intense experiences can lead to flashbacks when a person is reminded acutely of the original experience. However, not all published case reports of chronic flashbacks appear to describe an anxious hyper-vigilant state reminiscent of post-traumatic stress disorder.
Synonyms	Lysergidum Lysergic acid diethylamide (+)-LSD LSD 25 Lysergs?urediethylamid D-lysergic acid diethylamide N,N-diethyllysergamide Diethylamid kyseliny lysergove N,N-diethyl-D-lysergamide N,N-diethyl-(+)-lysergamide LSD Lysergide Lysergs?uredi?thylamid
Categories	Agents that produce hypertension Alkaloids Antidepressive Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Ergolines Ergot Alkaloids and Derivatives Hallucinogens Heterocyclic Compounds, Fused-Ring Lysergic Acid Neurotransmitter Agents Psychotropic Drugs Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT2 Receptor Agonists Serotonin Agents Serotonin Receptor Agonists Serotonin Receptor Antagonists
CAS number	50-37-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
5-hydroxytryptamine receptor 1A	MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCA...	unknown
5-hydroxytryptamine receptor 2B	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQ...	unknown	agonist
5-hydroxytryptamine receptor 6	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIAL...	unknown
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682