Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.[L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).[L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L12885] Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.[L12885]
Synonyms
Risperidonum
Risperidone tartrate
Risperidona
Risp¨Śridone
Risperidone
Brand Names
Apo-risperidone
Ran-risperidone
Dom-risperidone
Dom-risperidone ODT
Risvan
Teva-risperidone
Act Risperidone
Okedi
Risperidone - 3
Mint-risperidon
Ag-risperidone
Nu-risperidone
PMS-risperidone
Ipg-risperidone
Taro-risperidone
Jamp-risperidone
Ava-risperidone
Mylan-risperidone
Q-risperidone
Risperidone - 1
Risperidone Tablets
Sandoz Risperidone
Uzedy
Mar-risperidone
Mylan-risperidone ODT
PHL-risperidone
Risperidone - 0.5
Risperidone - 2
Risperidone - 4
Ratio-risperidone
Risperidone
Risperidone M-TAB
Risperdal Oral Solution
Pro-risperidone
Risperdal
PMS-risperidone ODT
Risperdal Consta
Risperdal M-tab
Riva-risperidone
PHL-risperidone ODT
Risperidone - 0.25
Truemed Group LLC
Rykindo extended-release microspheres
Perseris
Indication
Risperidone is indicated for the treatment of schizophrenia [L12885,L44692,L46297] and irritability associated with autistic disorder.[L12885] It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.[L12885,L44692] Risperidone is additionally indicated in Canada for the short-term symptomatic management of aggression or psychotic symptoms in patients with severe dementia of the Alzheimer type unresponsive to nonpharmacological approaches.[L12906] Risperidone is also used off-label for a number of conditions including as an adjunct to antidepressants in treatment-resistant depression.[A177226]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
