AMH

TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID

Created:	1999-07-08
Last modified:	2011-06-04

Find Related PDB Entry
7 entries where AMH is found as a standalone ligand

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	26
Chiral Atom Count	0
Bond Count	26
Aromatic Bond Count	0

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID
Systematic Name (OpenEye OEToolkits)	4-(aminomethyl)cyclohexane-1-carboxylic acid
Formula	C₈ H₁₅ N O₂
Molecular Weight	157.21
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C1CCC(CN)CC1
SMILES	CACTVS	3.341	NC[CH]1CC[CH](CC1)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C1CC(CCC1CN)C(=O)O
Canonical SMILES	CACTVS	3.341	NC[C@@H]1CC[C@H](CC1)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1CC(CCC1CN)C(=O)O
InChI	InChI	1.03	InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
InChIKey	InChI	1.03	GYDJEQRTZSCIOI-LJGSYFOKSA-N

Drug Info: DrugBank

DrugBank ID	DB00302 ?
Name	Tranexamic acid
Groups	approved
Description	Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent.[L31883] It was first patented in 1957[A230108] and received its initial US approval in 1986.[L31858]
Synonyms	trans-4-(Aminomethyl)cyclohexanecarboxylic acid ácido tranexámico trans-Amcha Tranexamic acid Acide tranéxamique trans-Tranexamic acid trans-4-aminomethylcyclohexane-1-carboxylic acid Tranhexamic acid Tranexmic acid Tranexamsaeure Trans AMCHA Acidum tranexamicum
Brand Names	Cyklokapron Tranexamic Acid Tablets Cyklokapron 500 mg Tranexamic acid Skinmd Laboratories Pure Whitenol Serum Cyklokapron 100 mg/ml Lysteda Tranexamic Acid Injection Pure Whitenol Serum Tranexamic Acid Injection BP Skinmd Laboratories Pure Whitenol Intensive Mar-tranexamic Acid Erfa-tranexamic Tranexamic Acid Injection, USP Tranexamic Acid In Sodium Chloride Tranexamic Acid Liquid SKINMD LABORATORIES ReviTox blue M-tranexamic Acid Gd-tranexamic Acid
Indication	Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema,[L31883] cyclic heavy menstrual bleeding in premenopausal females,[L31858] and other instances of significant bleeding in the context of hyperfibrinolysis.[L31883] Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.[L31853]
Categories	Acids, Carbocyclic Amino Acids Amino Acids, Peptides, and Proteins Antifibrinolytic Agents Blood and Blood Forming Organs Coagulants Cyclohexanecarboxylic Acids Cyclohexanes Cycloparaffins Decreased Fibrinolysis Fibrin Modulating Agents Hematologic Agents Hemostatics
ATC-Code	B02AA02
CAS number	1197-18-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Plasminogen	MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECA...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
CCDC/CSD	JIQGAU, JIQFIB, JIQGIC, KIBSOE, JIQFOH, ZUTZIA, COPWEK, JIQFAT, AMMCHC11, JIQFUN, AMMCHC10, JIQFEX, JIQHAV, JIQGUO, AMCHCA, JIQGEY, JIQGOI, ELOJUN