ASP

ASPARTIC ACID

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is present as a standalone ligand in 175 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 10 entries

is present in a polymer sequence 219,782 entries

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Chemical Component Summary
Name	ASPARTIC ACID
Identifiers	(2S)-2-azanylbutanedioic acid
Formula	C₄ H₇ N O₄
Molecular Weight	133.103
Type	L-PEPTIDE LINKING
Isomeric SMILES	C([C@@H](C(=O)O)N)C(=O)O
InChI	InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChIKey	CKLJMWTZIZZHCS-REOHCLBHSA-N

Chemical Details
Formal Charge	0
Atom Count	16
Chiral Atom Count	1
Bond Count	15
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00128 ?
Name	Aspartic acid
Groups	approved nutraceutical
Description	One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
Synonyms	Aspartic acid L-Aspartic acid Asp L-Asparagins?ure D (S)-2-aminobutanedioic acid Acidum asparticum 2-Aminosuccinic acid ácido aspártico L-Aspartate L-Asp (S)-2-aminosuccinic acid
Brand Names	Plenamine Aminosyn II with Electrolytes in Dextrose with Calcium Olimel 5.7% E Clinisol Olimel 5.7% Vamin 18 Electrolyte-free 20% Prosol Aminosyn II In Dextrose Injection Aminosyn II and Dextrose Premasol - sulfite-free (Amino Acid) Olimel 4.4% E Primene 10%-liq IV Aminosyn II 7% With 50% Dextrose Aminosyn II 10% With Electrolytes Aminosyn-PF 10% Primene Aminosyn II in Dextrose Novamine Aminosyn II 7% Injection Aminosyn II 8.5% Injection Periolimel 2.5% E Olimel 4.4% Aminosyn II 5% Inj Olimel 7.6% E ProSol Olimel 7.6% Olimel 3.3% E Primene 10% Aminosyn-PF 7% Aminosyn-PF Aminosyn II 7% M In 10% Dextrose(dual Chamber) Aminosyn II 7% With 10% Dextrose Vamin N Aminosyn II 8.5% With 50% Dextrose Kabiven Aminosyn II Aminosyn II with Electrolytes TrophAmine Perikabiven Aminosyn II 8.5% M In 20% Dextrose (dual Chamber)
Indication	There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.
Categories	Amino Acids Amino Acids, Acidic Amino Acids, Dicarboxylic Amino Acids, Peptides, and Proteins Dietary Supplements Excitatory Amino Acids Proteinogenic Amino Acids Supplements
CAS number	56-84-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Adenylosuccinate Synthetases	MSGTRASNDRPPGAGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVV...	unknown	substrate
Calcium-binding mitochondrial carrier protein Aralar2	MAAAKVALTKRADPAELRTIFLKYASIEKNGEFFMSPNDFVTRYLNIFGE...	unknown
Aspartate aminotransferase, cytoplasmic	MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWV...	unknown
Aspartoacylase	MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKP...	unknown
Asparagine synthetase [glutamine-hydrolyzing]	MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRL...	unknown	substrate
Argininosuccinate synthase	MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKK...	unknown
Aminoacylase-1	MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQ...	unknown
Aspartate aminotransferase, mitochondrial	MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEA...	unknown
Aspartate--tRNA ligase, cytoplasmic	MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRD...	unknown
Calcium-binding mitochondrial carrier protein Aralar1	MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDP...	unknown
Aspartyl/asparaginyl beta-hydroxylase	MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLS...	unknown
Multifunctional protein ADE2	MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHL...	unknown	substrate
Adenylosuccinate synthetase isozyme 2	MAFAETYPAASSLPNGDCGRPRARPGGNRVTVVLGAQWGDEGKGKVVDLL...	unknown
Excitatory amino acid transporter 3	MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKF...	unknown
Aspartate--tRNA ligase, mitochondrial	MYFPSWLSQLYRGLSRPIRRTTQPIWGSLYRSLLQSSQRRIPEFSSFVVR...	unknown
Isoaspartyl peptidase/L-asparaginase	MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEG...	unknown
Ribonuclease pancreatic	MALEKSLVRLLLLVLILLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSS...	unknown
Lysozyme C	MKALIVLGLVLLSVTVQGKVFERCELARTLKRLGMDGYRGISLANWMCLA...	unknown
CAD protein	MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQIL...	unknown	substrate
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	139060126, 5960, 44367445
ChEMBL	CHEMBL274323
ChEBI	CHEBI:17053
CCDC/CSD	MUCKUR01, MUCKUR, NELQUQ, MUCKUR02, YUFKUF, HUMLIK, DUSLUY, YIGNEJ, MUVXAC, VUYHII

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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ASP

ASPARTIC ACID

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References