AZR

2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid

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as a non-polymer is covalently linked to polymer or other heterogen groups 10 entries

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Chemical Component Summary
Name	2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid
Synonyms	AZTREONAM, open form
Identifiers	2-[(Z)-[1-(2-azanyl-1,3-thiazol-4-yl)-2-oxidanylidene-2-[[(2S,3S)-1-oxidanylidene-3-(sulfoamino)butan-2-yl]amino]ethylidene]amino]oxy-2-methyl-propanoic acid
Formula	C₁₃ H₁₉ N₅ O₈ S₂
Molecular Weight	437.449
Type	NON-POLYMER
Isomeric SMILES	C[C@@H]([C@@H](C=O)NC(=O)/C(=N\OC(C)(C)C(=O)O)/c1csc(n1)N)NS(=O)(=O)O
InChI	InChI=1S/C13H19N5O8S2/c1-6(18-28(23,24)25)7(4-19)15-10(20)9(8-5-27-12(14)16-8)17-26-13(2,3)11(21)22/h4-7,18H,1-3H3,(H2,14,16)(H,15,20)(H,21,22)(H,23,24,25)/b17-9-/t6-,7+/m0/s1
InChIKey	OEVQTUTXOVDNJO-GEEOIBTQSA-N

Chemical Details
Formal Charge	0
Atom Count	47
Chiral Atom Count	2
Bond Count	47
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB00355 ?
Name	Aztreonam
Groups	approved
Description	A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Synonyms	Aztréonam (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid Aztreonam lysine 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl) -2- {[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene]amino}oxy)-2-methylpropanoic acid Aztreonamum Aztreonam
Brand Names	Azactam Cayston Aztreonam
Indication	For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections.
Categories	Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use beta-Lactams Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Lactams Monobactam Antibacterial Monobactams Sulfur Compounds
ATC-Code	J01DF01
CAS number	78110-38-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Penicillin-binding protein 3	MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFDDMYQSL...	unknown	inhibitor
Beta-lactamase	MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAV...	unknown	potentiator
Beta-lactamase Toho-1	MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682