CEF

CEFOTAXIME, C3' cleaved, open, bound form

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is present as a standalone ligand in 2 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 25 entries

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Chemical Component Summary
Name	CEFOTAXIME, C3' cleaved, open, bound form
Identifiers	2-[1-[[(2Z)-2-(2-azanyl-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-2-oxidanylidene-ethyl]-5-methylidene-2H-1,3-thiazine-4-carboxylic acid
Formula	C₁₄ H₁₅ N₅ O₅ S₂
Molecular Weight	397.429
Type	NON-POLYMER
Isomeric SMILES	CO/N=C(/c1csc(n1)N)\C(=O)NC(C=O)C2N=C(C(=C)CS2)C(=O)O
InChI	InChI=1S/C14H15N5O5S2/c1-6-4-25-12(18-9(6)13(22)23)7(3-20)16-11(21)10(19-24-2)8-5-26-14(15)17-8/h3,5,7,12H,1,4H2,2H3,(H2,15,17)(H,16,21)(H,22,23)/b19-10-/t7-,12-/m1/s1
InChIKey	NRYMPLKBKFIWQC-YVCCLBOHSA-N

Chemical Details
Formal Charge	0
Atom Count	41
Chiral Atom Count	2
Bond Count	42
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB08375 ?
Name	(2R)-2-[(1R)-1-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-2-oxoethyl]-5-methylidene-2H-1,3-thiazine-4-carboxylic acid
Groups	experimental
Synonyms	Pcnotaxime group (2R)-2-[(1R)-1-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-2-oxoethyl]-5-methylidene-2H-1,3-thiazine-4-carboxylic acid

Drug Targets

Name	Target Sequence	Pharmacological Action
Penicillin-binding protein 1A	MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVAT...	unknown
Beta-lactamase Toho-1	MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGV...	unknown
Beta-lactamase	MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIY...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682