CHT

CHOLINE ION

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is present as a standalone ligand in 65 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 2 entries

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Chemical Component Summary
Name	CHOLINE ION
Identifiers	2-hydroxyethyl-trimethyl-azanium
Formula	C₅ H₁₄ N O
Molecular Weight	104.171
Type	NON-POLYMER
Isomeric SMILES	C[N+](C)(C)CCO
InChI	InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1
InChIKey	OEYIOHPDSNJKLS-UHFFFAOYSA-N

Chemical Details
Formal Charge	1
Atom Count	21
Chiral Atom Count	0
Bond Count	20
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00122 ?
Name	Choline
Groups	approved nutraceutical
Description	A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Synonyms	Vitamin J Choline ion trimethylethanolamine Choline chloride Choline Choline bitartrate Bilineurine N,N,N-trimethylethanol-ammonium N-trimethylethanolamine
Brand Names	Strazepam Super Stress Capsules Revitalize Multi-vitamin and Mineral Complex Multivitamins and Minerals for Young Men Choline 250mg Hi Potency Multi Tab Extra Once A Day Vita-vim - Tab Multi B NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Glyco Lite Ect Time Release B 100 Compound - Tablet B-plus - Tab Wellness Formula Protect Plus SO 60 Doctor's Choice Brand for Men Vitamin & Mineral Formula 1 Dietary Supplement Glyco Plus Ect Super-pote Vitamin Supplement Super B Compound W 500mg Vit C Cholinex Tab 200mg Lipotropic Ctr Liqui B Complex Plus Livita Adults Bev B-150 Duet DHA Balanced Sentradine Fem - Pmt Red American Eagle Vitamin Supplement Drink Vitamin B Complex W C Tab Hoa 1 Vit-HA Multi Vitamin and Zinc Supplement Lipotropic Adjunct Stress B With 1000 Mg Vitamin C Swiss One Multi Vit & Chel Min Tab Vitaphil DHA NESTABS Prenatal Multi-vitamin/Mineral Supplement Timed Release B Complex 100 Srt Choline Inositol Methionine Lipo Factors Plus B6 Mega Plex IV - Pck Vit B Complex Ctr Lipotrope Tab Choline Bitartrate 100mg-tab Vege 1 Daily Tab Twin G.F. Powder Vanilla Flavor Advanced 2000 Capsules B Complex 25mg Vitamin Supplement Complete One-A-day - Tab Gabitidine Multi-force for Women Tab B50 Complex Multivitamins and Minerals With Betacarotene Tablets Deriton Multivitamins and Minerals for Men Vita-B Multi II IV Vi Tab Vita B Complex Tab Trazamine Stressmates Vita Vim With Beta Carotene-caplet Mega Capsules 24 Multivitamins + Minerals Children's Chewable Multivitamins and Minerals Multivitamins and Minerals for Women Complete Mega B Stress B&c Tab Vege Swiss One Multivitamin W Chel Mins Tab Hi Potency Stress B Tension With C Forty Plus Vitamin Supplement Complete Multivitamins and Minerals Tablets Timed Release Folic Acid Plus Cavan Prenatal Multivitamin & Minerals (iron Free) VITAFOL Gummies Lipo-B-C Tab Sentravil PM-25 Biosculpt New Chapter's D'adamo 4 Your Type Multiple for Type O Phytovim Cap Mega Balance Prenatal, DHA Multivitamins and Minerals for Young Women Vita Vim Multivitamins and Minerals Tab Mega Vitaminerals Card-floe II Tab Spectrum 2 Cap Vita Balance 2000 Timed Release B-complex 50 B Complex 50 Vitamin Cap Gnc Choline/inositol 250mg Tablets Super Vita-vim With Beta-carotene - Tab Stress B Capsules With Vitamin C Lipall Plus Tab Mega Lipotropic Cap B Compound 50mg Tab Vitamin B Compound W Vit C 250mg Tab Vitamin B Tablets B-100 Caps B-complex Alertonic Nitro Vites - Tab Multi Plex II - Tab Vita-worth B-complex Tablets Stom #2 B-complex With Vitamin C, Biotin, Folic Acid Iron, Vit & Min Supp Daily Energy Brand B-complex Derma-force Lipotrope-plus B6 Tab Multi Flow Tablets Gabazolamine-0.5 50 Plus L Fac Tab Livertal 36 Choline Caps 350mg NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Mega Plex III - Pck Onccor Twin G.F. Powder Vitaplex Classic Swiss One 10 Multivitamin and Mineral Tab Gaboxetine One A Day Tab Magnum-75 Vitamin and Mineral Supplement B-50 Complex Grand Master Formula Tab Multi Vitamin-mineral Formula Complexe B Compose 75 Super Stress Mega B Plus 1000mg Vit C Tab Swiss One Timed Release Tab C. Vit-min Formula Stress Forte Plus Lipotropic Factors Hyporyl - Tab B-complex Tab Liqui B Complex B-complex-50 Tab Pretrate B Complex 50+ Caplet Vasula Tab Formula Hh Gabazolpidem-5 Swiss One Multivitamin and Mineral Caplet Usana Megavitamin Tablets - Tab Multi-force for Adults Tab Multicaps Only One - Tablet Chromium and Vanadium Mineral Supplement Balanced B 125 Srt Orti B Lipotropics 600 Tab Multi Spectrum - Tablet Choline 250 mg Multra With Iron Formula F L W Vita-vim With Beta-carotene - Tab Vita Plex Tab B-50 Hi Potency B Vitamins Tab Choline Tab 250mg Sentrazolam AM Vitaphil 90 DHA Revit Multi-vitamins and Minerals Harvest Of Values All B Complex Tab Mega 13 Multivitamin Formula Choline Ctr Srt 400mg Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Lipovite B-complex 50 Nata Komplete Gabavale-5 Body Rox Ultr F/b E.S. Mega Lipotropic Fmla W B6bet Lip - Fac Formula Pro Pcos Citrus Ultra Hr Proteminal Timed Release B-complex 100 Maintain Multiple Vitamin & Minerals Rocky Mountain Multiple Vit and Min Mega Tab Nutri-Tab OB plus DHA Olympian Multi Vit Plus Minerals Tab Super Vita Vim Multivitamins and Minerals Men's 50+ Multivitamine For-2 Maximum Once A Day Men's Biomultiple Vitamin and Mineral Supplement One A Day Multiple Vit W Minerals Prenatal Vi-min Right Choice P.M. Multi Formula - Caplet Vitalife - Capsule Choline and Inositol 250mg/250mg B 50 Capsules Stress Formula B-comp + 500mg Vit C Tab Twin Opti Pwr Mangadyn Prometa Multi-phyto Capsules Formula Gly Liqui Vita Men's Multi Master Formula Sentrazolpidem PM-5 Senophylline Livita Children Vitamin B Compound W C Tab 500mg Pro Hers Vanilla Sentralopram AM-10 Vitamin B Complex 100 Tab Essential B Tablets Dp 2000 Alkadrenergy Tablets B-plex Formula Cm Bev 29 Tab Palm Spring's PM Form Tab Sentroxatine Multipack II Women's Formula Prenatryl Hi Potency B Complex W Chelated Minerals Mega-vim 75 With Beta-carotene - Tablets Multi Tabs Multivitamin & Multimineral Nrg Plus Liq Choline Bitartrate 500 Mg - Tablet Prenatal Formula Tab Nutri-Tab OB Natural Source Spectrum With Beta Carotene Mini-B Tab Phytopure B-100 Vitamin Supplement Stress Ctr Srt Super Daily No 2 Maxum Multi-vite Super Multi Liquid B Complex 50 Multi Plex I - Tab Hi Potency B52 B Complex Tab Low Potency B Complex Tab Swiss One Prenatrix Stress Formula Multi-B Comp + 500mg Vit C Cap Stress Formula Vit B With C Complex B-100 Hi Potency B Vitamins Tab Maxine Vitamin and Mineral Supplement Innersource Tab American Plus Energy & Vitamin Drink Multitabs L.C. Supplement Master Key Multi Vitamin Multi Mineral Formula 2 Gabazolamine Children's Chew Multi & Min Tab B-complex 100 Fusion PM Formula Tab Complete One A Day Tab Sentraflox AM-10 Stress B & C Caplet Betacol Vitamin B Complex Suppl Choline & Inositol Caps Women's Biomultiple Vitamin and Mineral Supplement Gesticare DHA Pour Ma Santé Multra Plex American Eagle Energizer Plus Vitamin Supplement Drink Timed Release Vita-vim Srt Formula Lf Ultimate Tab V-Natal Insur-all Vitamin Supplement Vitamin B + C Cap Vitamin B Complex 50 Children's Chewable Vit and Min Tab Stress Vitamin B With C Complex Tablets Body Tropics Plus Tab Bev-lipo-1000 Multiple Vitamins and Minerals Capsules H.W. Children's Chewable Multi Vit & Mineral
Indication	For nutritional supplementation, also for treating dietary shortage or imbalance
Categories	Alcohols Amines Amino Alcohols Analgesics Antimetabolites Central Nervous System Agents Dietary Supplements Ethanolamines Gastrointestinal Agents Hypolipidemic Agents Lipid Regulating Agents Lipotropic Agents Nervous System Nootropic Agents OCT1 inhibitors OCT1 substrates OCT2 Inhibitors OCT2 Substrates Onium Compounds Other Nutritional Agents Quaternary Ammonium Compounds Salicylic Acid and Derivatives Supplements Trimethyl Ammonium Compounds Vitamin B Complex Vitamins
CAS number	62-49-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Neuronal acetylcholine receptor subunit alpha-7	MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQP...	unknown
Choline-phosphate cytidylyltransferase B	MPVVTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADE...	unknown	product of
Acetylcholinesterase	MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG...	unknown	product of
Choline-phosphate cytidylyltransferase A	MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDE...	unknown	product of
Phospholipase D2	MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQ...	unknown	product of
Cholinesterase	MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFG...	unknown	product of
Phospholipase D1	MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPK...	unknown	product of
Phosphoethanolamine/phosphocholine phosphatase	MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAA...	unknown	product of
Choline/ethanolaminephosphotransferase 1	MSGHRSTRKRCGDSHPESPVGFGHMSTTGCVLNKLFQLPTPPLSRHQLKR...	unknown	substrate
Choline/ethanolamine kinase	MAAEATAVAGSGAVGGCLAKDGLQQSKCPDTTPKRRRASSLSRDAERRAY...	unknown	substrate
Choline O-acetyltransferase	MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGG...	unknown	substrate
Choline kinase alpha	MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGG...	unknown	substrate
Choline dehydrogenase, mitochondrial	MWCLLRGLGRPGALARGALGQQQSLGARALASAGSESRDEYSYVVVGAGS...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown	substrate,inhibitor
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
Choline transporter-like protein 1	MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSI...	unknown	substrate
Choline transporter-like protein 4	MGGKQRDEDDEAYGKPVKYDPSFRGPIKNRSCTDVICCVLFLLFILGYIV...	unknown	substrate
Choline transporter-like protein 2	MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAV...	unknown	substrate
Choline transporter-like protein 3	MHCLGAEYLVSAEGAPRQREWRPQIYRKCTDTAWLFLFFLFWTGLVFIMG...	unknown	substrate
High affinity choline transporter 1	MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIG...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	305
ChEMBL	CHEMBL920
ChEBI	CHEBI:15354
CCDC/CSD	IBUNOJ, HAWWAF, CHOCHL04, SAPQAE, NIJHOF, MOGZAJ, DIJCIJ, DEJWEX, LEKSAV, HAWVUY, HAWVAE, BAVBIL, HAWVOS, HAWVIM, GIBMIQ, KOYWAW, HAWVEI, BUFFUD, LEKRIC, LEKRUO, GIBMIQ04, GIBMIQ01, NORDAA, GIBMIQ05, HABBOD, GIBMIQ02, PEJVAE, GIBMIQ03, SOQVEB, DEJWEX01, LEKROI, HEGWIB, HABBIX, ODIHOZ, FOPMOM, COXYUK, ICUWAF, FIZNIO, KUKYUM, QEGFAJ, SIMSOZ, EJEZAX, EHIQAQ, EHIPUJ
COD	7229208

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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CHT

CHOLINE ION

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References