CL6

1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE

Created:	2006-10-26
Last modified:	2021-03-01

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9 entries where CL6 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	42
Chiral Atom Count	0
Bond Count	45
Aromatic Bond Count	23

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Chemical Component Summary
Name	1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE
Synonyms	CLOTRIMAZOLE
Systematic Name (OpenEye OEToolkits)	1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
Formula	C₂₂ H₁₇ Cl N₂
Molecular Weight	344.837
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
Canonical SMILES	CACTVS	3.341	Clc1ccccc1C(n2ccnc2)(c3ccccc3)c4ccccc4
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)C(c2ccccc2)(c3ccccc3Cl)n4ccnc4
InChI	InChI	1.03	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	InChI	1.03	VNFPBHJOKIVQEB-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00257 ?
Name	Clotrimazole
Groups	approved vet_approved
Description	This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Synonyms	1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole Clotrimazol 1-(o-Chlorotrityl)imidazole Clotrimazolum Clotrimazole 1-(o-Chloro-α,α-diphenylbenzyl)imidazole 1-(α-(2-Chlorophenyl)benzhydryl)imidazole
Brand Names	Live Better Antifungal 1MED Clotrimazole 1% Antifungal Cream Canesten Crm 1% Vag Clotrimazole Clotrimazole Vaginal 3 meijer Clotrimazole 3 Terrasil Tinea Treatment MAX Antifungal Clotrimazole Cream 1% Anti Fungal Gehwol med Foot Gyne-Lotrimin 7 Micotrin AC Walgreens Jock Itch Canesten Combi 3 Day Athletes Foot Antifungal Antifungal Myclo-gyne Inserts Alevazol Myclo Crm 10mg Aspiera Anti-Fungal Clotrimaderm Topical Anti-Fungal Cream Fastrin Anti - Fungal Skin Care Jock Itch Clotrimazole Antifungal First Aid Research Antifungal .5oz Clotrimazole Antifungal Lotrisone Clotrimazole Topical Solution USP, 1% Signature Care Antifungal Canesten 1% Topical Cream Canesten Comfortab 3 Aptrimazole 1.0% Antifungal Cream Meijer Clotrimazole Antifungal Myclo-derm Solution 1% Our Family Athletes Foot Fortinia OF Rugby Clotrimazole Antifungal Cream Terbinafine HCl Chlortimazole and Tolnaftate Terrasil Athletes Foot AntiFungal Treatment Max Au Kah Chuen Antifungal Terrasil Foot and Nail Anti-Fungal Forticept Antifungal Foot Gel Pedesil Athletes Foot Ciclomazole Good Neighbor Pharmacy Clotrimazole 3 WinCo Antifungal Thera plus Antifungal Clotrimazole Leader Clotrimazole Anti-Fungal Best Choice Clotrimazole Clotrimazole Topical Fungicure Intensive Fungistat Max Taro-clotrimazole/betamethasone Dipropionate Up and Up Jock Itch Relief JiDeSheng Rexall Athletes Foot Pedesil Maximum Strength Budpak Antifungal Clotrimazole Protective Nail and skin Topcare Athletes Foot Canesten 2% Vaginal Cream Terrasil Ringworm Treatment MAX Clotrimaderm Vaginal 6 Botanimedix TineaRX Antifungal Drying Emulsion Family Wellness Antifungal Walgreens Clotrimazole TM-Clotrimazole Athlete s Foot Afac Clotrimaderm-fluconazole Combi-pack Fortinia Meijer Athletes Foot Cream AF Family Wellness Clotrimazole 1 Anti Fungal Cream Hua Tuo Xian Gao Antifungal Terrasil JockItch Treatment Maximum Strength Canesten Combi 1 Day Internal + External Creams Votriza-AL Rexall Jock Itch Fungicure Manicure Pedicure Anti Fungal Myclo Tab 100mg Cura Hongo Antifungal Gerlasan Hand Goodsense Athletes Foot Neo-zol Vaginal Cream 1% SoundBody Clotrimazole Antifungal Canesten 1% Topical Solution Canesten Combi-pak 1 Day Therapy Canesten Comfortab 1 Clotrimazole and Betamethasone Dipropionate Myclo Crm 50mg Clotrimazole Jock Itch Canesten 6 Day Internal Cream Canesten Liq 1% Occulus SKIN HYDRATING TOPICAL FOAM CLO-1 ANTIFUNGAL FOAM Clotrimazole Topical Solution 1% Blossom Pharmaceuticals Antifungal Canesten External Antifungal Cream Footlogix Healthy Accents Antifungal CAREALL Clotrimazole Kroger ATHLETES FOOT Canesten 1 Vaginal Tablet Combi-pak Smooth Gator Fungus Eliminator Dr Sheffield Athletes Foot Neo-zol Vaginal Cream 2% PRO-EX Anti Fungal Occulus Skin Hydrating Topical Foam CLO-1 CVS Clotrimazole Maximum Strength Soothing Antifungal Cream TopCare Antifungal Family Care Clotrimazole Antifungal CVSHealth Antifungal Equaline Clotrimazole Antifungal Clotrimazole 1% Kleer-Plex Fungistat Fungus Cure Scheinpharm Clotrimazole 1% Clotrimaderm External Cream Canesten Vaginal Inserts 100mg Clotrimazole Athletes Foot SIMPLY VITAL Antifungal Cream Terrasil Antifungal Cream Maximum Strength CVS Pharmacy ITCH RELIEF ANTIFUNGAL Lucky SuperSoft Athletes Foot Athlete Foot Cream with Clotrimazole Femmesil Dermatin Antifungal Dynarex Antifungal Family Care Clotrimazole Anti-Fungal Cream 1% PMS-clotrimazole-betamethasone Walgreens Clotrimazole Antifungal Lotrimin Antifungal Rugby Antifungal Clotrimazole Footlogix Intensive Care Diabetic Formula Clotrimazol Dual Terrasil Anti-Fungal Treatment Canesten 200 Mg Vaginal Inserts Clotrimazole/Betameth Canesten Combi 1 Day Soft Capsule + Extra Strength External Cream Walgreens Clotrimazole 3 Equaline Antifungal Cream Gehwol Fusskraft Nail and Skin Protection Lotrimin Foot Care Clotrimazole MakeSense Lakesia Canesten V PerfectHeal Antifungal Signature Care Athletes Foot Silka Ringworm Smart Sense Athletes Foot Antifungal Canesoral Combi Terrasil Anti-Fungal Treatment MAX Forticept Antifungal Cooling Antifungal Cream sunmark Clotrimazole 3 CVS Pharmacy Clotrimazole 3 Shopko Athletes Foot TopCare Clotrimazole 3 Myclo-derm Cream 1% Clotrimazole 1% Topical Antifungal Cream Publix athletic foot Fungicure Liquid Gel Zapotol Clotrimazole Canesten 3 Vaginal Tablet Combi-pak Canesten Crm 1% Top Clotrimaderm Topical Solution 1% USP Kerasal foot and toe Rite Aid antifungal ringworm Terrasil Tinea Treatment Maximum Strength Good Sense Athletes Foot antifungal S-Cream CLOTRIMAZOLE Cream 1% TerrasilMed ANTIFUNGAL Clotrimazol Canesten Combi 1 Day Comfortab + Extra Strength External Cream Betamethasone Clotrimazole Leader Athletes Foot Clotrimazole Jock-eze Major Clotrimazole UpandUp Clotrimazole Astonea Clotrimazole 1% Athletes Foot First Aid Research Antifungal Cream 1oz Kroger Jock Itch CAREONE Clotrimazole Canesoral Combi 1 Day Extra Strength Clotrimazole Extra Fort -fluconazole Combi Jock Itch Antifungal Exchange Select Atheletes foot Protective and Moisturizing Skin ShopRite antifungal Clotrimazole 1% Athletes Foot Canesten External Cream Lotriderm Clotrimazole External Antifungal Cream DermacinRx Therazole Pak ClotrimazOil Antifungal Antifungal Foot Canesten 1 Day Internal Cream Forticept Antifungal Foot Cream Myclo-gyne Cream 1% Family Care Antifungal Fungicure Manicure Pedicure Oheal Ringworm Cream Hua Tuo Xian Gao Olp Clotrimazole Shield and Protect Anti-Fungal Skin Repair Sunmark Clotrimazole Terrasil Jock Itch Treatment Maximum Strength Western Family Athletes Foot Clotrimazole Extra Strength External Antifungal Cream WinCo Foods Antifungal Oheal Manuka Honey Eczema Cream Mycozyl AC Fungicure Manicure Pedicure Liquid Gel meijer Athletes Foot Terrasil Jock-Itch Treatment MAX Quality Choice Clotrimazole Jock Itch Cream with Clotrimazole Canesten Soft Capsule 1 Good Neighbor Pharmacy Clotrimazole Gyne-Lotrimin 3 Signature Care Jock Itch Terrasil Foot and Nail Anti-Fungal Maximum Strength Jock Itch Kleer-Plex Fungistat Athlete Foot Cure Myclo Solution Quality Choice Athletes Foot Ringworm FungaZoil Advanced TheraPlus Plus HEB Antifungal Clotrimazole Vaginal 6 Canesten 3 Day Internal Cream Mycelex Neo-zol Cream 1% Terrasil Anti-fungal Treatment Gehwol Nail Protection Pen Fungicure Pumpspray Clotrimazole External Cream Akin Anti-fungal Anti-Fungal Canesten Extra Strength External Antifungal Cream Terrasil Rapid-Clear Anti-Fungal Canesten 100mg Vaginal Inserts Atopalm Clotrimazole Antifungal Up and Up Athletes Foot Equate Jock Itch Clotrimaderm Vaginal 3 CVS Antifungal Ringworm Desenex Clotrimazole-fluconazole Combi Canesten Combi 1 Day
Indication	Topical preparations Clotrimazole topical cream is indicated for the topical treatment of the following dermal infections [F3088], [F3121]: Tinea pedis, tinea cruris, and tinea corporis due to _Trichophyton rubrum_, _Trichophyton mentagrophytes_, _Epidermophyton floccosum_ Candidiasis due to _Candida albicans_ Tinea versicolor due to _Malassezia furfur_ Diaper rash infected by _Candida albicans_ In some preparations, clotrimazole may be combined with betamethasone dipropionate, a corticosteroid [F3121]. Oral preparations The oral troche preparation is indicated for the local treatment of oropharyngeal candidiasis [FDA label]. It is also indicated as a prophylactic drug to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions such as chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation [FDA label]. Troche preparations are not indicated for the treatment of any systemic mycoses [FDA label].
Categories	Anti-Infective Agents Anti-Infective Agents, Local Antifungal Agents Antifungal Agents (Vaginal) Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives and Antiseptics for Local Oral Treatment Azole Antifungals BSEP/ABCB11 Inhibitors BSEP/ABCB11 Substrates Cytochrome P-450 CYP2A6 Inhibitors Cytochrome P-450 CYP2A6 Inhibitors (strong) Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2B6 Inhibitors Cytochrome P-450 CYP2B6 Inhibitors (strong) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (moderate) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (moderate) Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2E1 Inhibitors Cytochrome P-450 CYP2E1 Inhibitors (moderate) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A7 Inducers Cytochrome P-450 CYP3A7 Inducers (strong) Cytochrome P-450 CYP3A7 Inducers (weak) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Enzyme Inhibitors Gynecological Antiinfectives and Antiseptics Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives Imidazole Derivatives Imidazoles OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates OATP1B3 inducers P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Steroid Synthesis Inhibitors Stomatological Preparations
ATC-Code	D01AC01 A01AB18 G01AF02 G01AF20
CAS number	23593-75-1

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
C-X-C chemokine receptor type 2	MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYF...	unknown	modulator
Lanosterol 14-alpha demethylase	MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPL...	unknown	antagonist,inhibitor
Intermediate conductance calcium-activated potassium channel protein 4	MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFG...	unknown	inhibitor
Ergosterol	-	unknown	inhibitor
Nuclear receptor subfamily 1 group I member 2	MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATG...	unknown	activator
Hydroxycarboxylic acid receptor 2	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALW...	unknown	partial agonist
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inhibitor,inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inhibitor,inducer
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	inhibitor
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inhibitor
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	inhibitor
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	inducer
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor,inducer
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B1	MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKS...	unknown	substrate,inhibitor
Solute carrier organic anion transporter family member 1B3	MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKI...	unknown	inducer
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682