DHF
DIHYDROFOLIC ACID
Find entries where: DHF
is present as a standalone ligand in 18 entries
as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries
Chemical Component Summary | |
|---|---|
| Name | DIHYDROFOLIC ACID |
| Identifiers | (2S)-2-[[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]phenyl]carbonylamino]pentanedioic acid |
| Formula | C19 H21 N7 O6 |
| Molecular Weight | 443.413 |
| Type | NON-POLYMER |
| Isomeric SMILES | c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=NC3=C(NC2)NC(=NC3=O)N |
| InChI | InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1 |
| InChIKey | OZRNSSUDZOLUSN-LBPRGKRZSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 53 |
| Chiral Atom Count | 1 |
| Bond Count | 55 |
| Aromatic Bond Count | 12 |
Drug Info: DrugBank
| DrugBank ID | DB02015? |
|---|---|
| Name | Dihydrofolic Acid |
| Groups | experimental |
| Synonyms | Dihydrofolic Acid |
| Brand Names |
|
| CAS number | 4033-27-6 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Dihydrofolate reductase | MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI... | unknown | |
| Putative pteridine reductase 2 | MNETSHEASECPAAIITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQ... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| PubChem | 135398604, 98792, 5280349 |
| ChEMBL | CHEMBL46294 |
| ChEBI | CHEBI:15633 |
