EPA

5,8,11,14,17-EICOSAPENTAENOIC ACID

Find entries where: EPA

is present as a standalone ligand in 8 entries

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Chemical Component Summary
Name	5,8,11,14,17-EICOSAPENTAENOIC ACID
Identifiers	(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
Formula	C₂₀ H₃₀ O₂
Molecular Weight	302.451
Type	NON-POLYMER
Isomeric SMILES	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)O
InChI	InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
InChIKey	JAZBEHYOTPTENJ-JLNKQSITSA-N

Chemical Details
Formal Charge	0
Atom Count	52
Chiral Atom Count	0
Bond Count	51
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00159 ?
Name	Icosapent
Groups	approved nutraceutical
Description	Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Synonyms	5,8,11,14,17-eicosapentaenoic acid Icosapentum Timnodonic acid (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid 5,8,11,14,17-Icosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid Icosapento (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate Icosapentaenoic acid Icosapent all-cis-5,8,11,14,17-eicosapentaenoic acid all-cis-5,8,11,14,17-icosapentaenoic acid all-cis-icosa-5,8,11,14,17-pentaenoic acid Eicosapentaenoic acid cis-5,8,11,14,17-eicosapentaenoic acid EPA (all-Z)-5,8,11,14,17-eicosapentaenoic acid cis-5,8,11,14,17-EPA Icosapent sodium cis-delta(5,8,11,14,17)-Eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid
Brand Names	Vp-CH-pnv Taliment Se-Tan DHA Reliven Super Omega 3 Cavan One Vp-pnv-dha Premium Omega 3 Folcaps Care One Herbalifeline TriStart DHA Prenate Essential Melittin Joint Soothing Ge NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA VITAFOL Gummies Se-Plete DHA Dothelle DHA Oveeza CitraNatal Essence Ultra Omega 3 Gel Zatean-Pn Plus TL-Care DHA Protect Cardio AF CitraNatal Assure UltimateCare ONE NF Virt-Care One Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Taliva CitraNatal DHA Tricare Prenatal 2-part Daily Prenatal Vitamin System Virt-PN Plus WestGel DHA Virt-C DHA A2A Omega-3 natelle COMPLETE A2A Omega 3 WesCap-C-DHA Docosavit Nutri-Tab OB plus DHA Natelle One Tricare Prenatal DHA One With Folate Animi-3 with Vitamin D Virt-Bal DHA Plus Folcaps Omega-3 Tricare Prenatal DHA One Rx Multivitamin NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Gesticare DHA PNV-Omega Tricare Prenatal Twist-off DHA Soft Quick Dissolve Omega-3 Iq Childrens Chewable Tricare Prenatal DHA One BP Vit 3 Animi-3
Indication	EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.
Categories	Agents causing hyperkalemia Agents that produce hypertension Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Dietary Fats Dietary Fats, Unsaturated Dietary Supplements Eicosanoids Fats Fatty Acids Fatty Acids, Omega-3 Fatty Acids, Unsaturated Fish Oils Hypolipidemic Agents Lipids Nephrotoxic agents Non COX-2 selective NSAIDS Oils Supplements
CAS number	10417-94-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Prostaglandin G/H synthase 1	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...	unknown	inhibitor
Peroxisome proliferator-activated receptor gamma	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL...	unknown	agonist,regulator
Peroxisome proliferator-activated receptor delta	MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSS...	unknown	agonist
Free fatty acid receptor 1	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGC...	unknown	agonist
Sodium/calcium exchanger 1	MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECT...	unknown	inhibitor
Fatty acid-binding protein, brain	MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKV...	unknown	agonist
Fatty acid desaturase 1	MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTR...	unknown	agonist
Long-chain-fatty-acid--CoA ligase 4	MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKP...	unknown	inducer
Transient receptor potential cation channel subfamily V member 1	MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...	unknown	inducer
Peroxisome proliferator-activated receptor alpha	MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFG...	unknown
Arachidonate 5-lipoxygenase	MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGA...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682