RCSB PDB - FME Ligand Summary Page

Chemical Component Summary
Name	N-FORMYLMETHIONINE
Identifiers	(2S)-2-formamido-4-methylsulfanyl-butanoic acid
Formula	C₆ H₁₁ N O₃ S
Molecular Weight	177.221
Type	L-PEPTIDE LINKING
Isomeric SMILES	CSCC[C@@H](C(=O)O)NC=O
InChI	InChI=1S/C6H11NO3S/c1-11-3-2-5(6(9)10)7-4-8/h4-5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
InChIKey	PYUSHNKNPOHWEZ-YFKPBYRVSA-N

Chemical Component Summary

Name

N-FORMYLMETHIONINE

Identifiers

(2S)-2-formamido-4-methylsulfanyl-butanoic acid

Formula

C₆ H₁₁ N O₃ S

Molecular Weight

177.221

Type

L-PEPTIDE LINKING

Isomeric SMILES

CSCC[C@@H](C(=O)O)NC=O

InChI

InChI=1S/C6H11NO3S/c1-11-3-2-5(6(9)10)7-4-8/h4-5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1

InChIKey

PYUSHNKNPOHWEZ-YFKPBYRVSA-N

Chemical Details
Formal Charge	0
Atom Count	22
Chiral Atom Count	1
Bond Count	21
Aromatic Bond Count	0

Chemical Details

Formal Charge

Atom Count

Chiral Atom Count

Bond Count

Aromatic Bond Count

Drug Info: DrugBank

DrugBank ID	DB04464 ?
Name	N-Formylmethionine
Groups	experimental
Description	N-Formylmethionine is effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well as in the mitochondria of eucaryotic cells.
Synonyms	N-Formylmethionine N-formyl-L-methionine (2S)-2-(formylamino)-4-(methylthio)butanoic acid Formyl-methionine L-N-Formylmethionine
Categories	Amino Acids Amino Acids, Peptides, and Proteins Amino Acids, Sulfur Sulfur Compounds
CAS number	4289-98-9

Drug Targets

Name	Target Sequence	Pharmacological Action
Geranylgeranyl transferase type-2 subunit alpha	MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLE...	unknown
Geranylgeranyl transferase type-2 subunit beta	MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGI...	unknown
Photosynthetic reaction center cytochrome c subunit	MKQLIVNSVATVALASLVAGCFEPPPATTTQTGFRGLSMGEVLHPATVKA...	unknown
Reaction center protein H chain	MYHGALAQHLDIAQLVWYAQWLVIWTVVLLYLRREDRREGYPLVEPLGLV...	unknown
Reaction center protein L chain	MALLSFERKYRVRGGTLIGGDLFDFWVGPYFVGFFGVSAIFFIFLGVSLI...	unknown
Reaction center protein M chain	MADYQTIYTQIQARGPHITVSGEWGDNDRVGKPFYSYWLGKIGDAQIGPI...	unknown
Light-harvesting protein B-800/820 alpha chain	MNQGKIWTVVPPAFGLPLMLGAVAITALLVHAAVLTHTTWYAAFLQGGVK...	unknown
Light-harvesting protein B-800/820 beta chain	AEVLTSEQAEELHKHVIDGTRVFLVIAAIAHFLAFTLTPWLH	unknown
Light-harvesting protein B-800/850 alpha chain	MNQGKIWTVVNPAIGIPALLGSVTVIAILVHLAILSHTTWFPAYWQGGVK...	unknown
Light-harvesting protein B-800/850 beta chain	ATLTAEQSEELHKYVIDGTRVFLGLALVAHFLAFSATPWLH	unknown
Antithrombin-III	MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMN...	unknown
Beta-2-microglobulin	MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGF...	unknown
NADH-ubiquinone oxidoreductase chain 1	MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFA...	unknown
HLA class I histocompatibility antigen, B-27 alpha chain	MRVTAPRTLLLLLWGAVALTETWAGSHSMRYFHTSVSRPGRGEPRFITVG...	unknown
Respiratory nitrate reductase 1 alpha chain	MSKFLDRFRYFKQKGETFADGHGQLLNTNRDWEDGYRQRWQHDKIVRSTH...	unknown
Respiratory nitrate reductase 1 beta chain	MKIRSQVGMVLNLDKCIGCHTCSVTCKNVWTSREGVEYAWFNNVETKPGQ...	unknown
Respiratory nitrate reductase 1 gamma chain	MQFLNMFFFDIYPYIAGAVFLIGSWLRYDYGQYTWRAASSQMLDRKGMNL...	unknown
Protein S100-G	MSTKKSPEELKRIFEKYAAKEGDPDQLSKDELKLLIQAEFPSLLKGPNTL...	unknown
Rubredoxin	MKKYVCTVCGYEYDPAEGDPDNGVKPGTSFDDLPADWVCPVCGAPKSEFE...	unknown
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVA...	unknown
Cytochrome c oxidase subunit 1	MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGN...	unknown
Cytochrome c oxidase subunit 2	MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKL...	unknown
Cytochrome c oxidase subunit 3	MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTN...	unknown
Cytochrome c oxidase subunit 5A, mitochondrial	MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDE...	unknown
Cytochrome c oxidase subunit 5B, mitochondrial	MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLERE...	unknown
Cytochrome c oxidase subunit 6C	MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYA...	unknown
Cytochrome c oxidase subunit 7B, mitochondrial	MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCI...	unknown
Cytochrome c oxidase subunit 7C, mitochondrial	MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFA...	unknown
Cytochrome c oxidase subunit 8A, mitochondrial	MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVT...	unknown
Cytochrome c oxidase subunit 6A2, mitochondrial	MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLH...	unknown
Cytochrome c oxidase subunit 6B1	MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGD...	unknown
Cytochrome c oxidase subunit 7A1, mitochondrial	MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDN...	unknown
Methionyl-tRNA formyltransferase	MSESLRIIFAGTPDFAARHLDALLSSGHNVVGVFTQPDRPAGRGKKLMPS...	unknown
Streptavidin	MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLG...	unknown
Protein S100-B	MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKE...	unknown
Delta-hemolysin	MAQDIISTIGDLVKWIIDTVNKFTKK	unknown
Polyubiquitin-C	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQL...	unknown
AtpH	MESNLTTAASVIAAALAVGIGSIGPGLGQGQAAGQAVEGIARQPEAEGKI...	unknown
Probable L-ascorbate-6-phosphate lactonase UlaG	MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWL...	unknown
Immunoglobulin G-binding protein G	MEKEKKVKYFLRKSAFGLASVSAAFLVGSTVFAVDSPIEDTPIIRNGGEL...	unknown
Glutamate--cysteine ligase	MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGS...	unknown
Ribonuclease pancreatic	MALEKSLVRLLLLVLILLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSS...	unknown
Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHA...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682