Chemical Component Summary | |
|---|---|
| Name | FORSKOLIN |
| Identifiers | [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] ethanoate |
| Formula | C22 H34 O7 |
| Molecular Weight | 410.501 |
| Type | NON-POLYMER |
| Isomeric SMILES | CC(=O)O[C@H]1[C@H]([C@H]2C(CC[C@@H]([C@@]2([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O)(C)C)O |
| InChI | InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1 |
| InChIKey | OHCQJHSOBUTRHG-KGGHGJDLSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 63 |
| Chiral Atom Count | 8 |
| Bond Count | 65 |
| Aromatic Bond Count | 0 |
Drug Info: DrugBank
| DrugBank ID | DB02587? |
|---|---|
| Name | Colforsin |
| Groups |
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| Description | Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland. |
| Synonyms |
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| Categories |
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| CAS number | 66575-29-9 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Adenylate cyclase type 2 | MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFL... | unknown | |
| Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGE... | unknown | |
| Adenylate cyclase type 5 | MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSA... | unknown | |
| Cystic fibrosis transmembrane conductance regulator | MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLS... | unknown | inhibitor |
| Adenylate cyclase | MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFR... | unknown | activator |
| View More | |||
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| Pharos | CHEMBL52606 |
| PubChem | 47936 |
| ChEMBL | CHEMBL52606 |
| ChEBI | CHEBI:42471 |
| CCDC/CSD | FRSKLN02 |
