FOL

FOLIC ACID

Created:	1999-07-08
Last modified:	2011-06-04

Find Related PDB Entry
133 entries where FOL is found as a standalone ligand

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	51
Chiral Atom Count	1
Bond Count	53
Aromatic Bond Count	17

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	FOLIC ACID
Systematic Name (OpenEye OEToolkits)	(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]phenyl]carbonylamino]pentanedioic acid
Formula	C₁₉ H₁₉ N₇ O₆
Molecular Weight	441.397
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(NC(=O)c1ccc(cc1)NCc2nc3c(nc2)NC(=NC3=O)N)CCC(=O)O
SMILES	CACTVS	3.341	NC1=NC(=O)c2nc(CNc3ccc(cc3)C(=O)N[CH](CCC(O)=O)C(O)=O)cnc2N1
SMILES	OpenEye OEToolkits	1.5.0	c1cc(ccc1C(=O)NC(CCC(=O)O)C(=O)O)NCc2cnc3c(n2)C(=O)N=C(N3)N
Canonical SMILES	CACTVS	3.341	NC1=NC(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2N1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCc2cnc3c(n2)C(=O)N=C(N3)N
InChI	InChI	1.03	InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChIKey	InChI	1.03	OVBPIULPVIDEAO-LBPRGKRZSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00158 ?
Name	Folic acid
Groups	approved vet_approved nutraceutical
Description	Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic acid is particularly important during phases of rapid cell division, such as infancy, pregnancy, and erythropoiesis, and plays a protective factor in the development of cancer. As humans are unable to synthesize folic acid endogenously, diet and supplementation is necessary to prevent deficiencies. For example, folic acid is present in green vegetables, beans, avocado, and some fruits.[L5744] In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as [DB00563] as they function as DHFR inhibitors to prevent DNA synthesis in rapidly dividing cells, and therefore prevent the formation of DHF and THF. When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, [DB00563] impedes the body's ability to create folic acid. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects. As a result, supplementation with 1-5mg of folic acid is recommended to prevent deficiency and a number of side effects associated with MTX therapy including mouth ulcers and gastrointestinal irritation. [DB00650] (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. Levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF) and are able to bypass DHFR reduction to act as a cellular replacement for the co-factor THF. There are also several antiepileptic drugs (AEDs) that are associated with reduced serum and red blood cell folate, including [DB00564] (CBZ), [DB00252] (PHT), or barbiturates.[A37004] Folic acid is therefore often provided as supplementation to individuals using these medications, particularly to women of child-bearing age. Inadequate folate levels can result in a number of health concerns including cardiovascular disease, megaloblastic anemias, cognitive deficiencies, and neural tube defects (NTDs). Folic acid is typically supplemented during pregnancy to prevent the development of NTDs and in individuals with alcoholism to prevent the development of neurological disorders, for example.
Synonyms	Folacin Vitamin B9 Vitamin M Folate sodium Folic acid Fols?ure N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid N-pteroyl-L-glutamic acid Pteroyl-L-glutamic acid PGA Acide folique Pteroyl-L-monoglutamic acid ácido fólico Vitamin Bc Acidum folicum Folate Pteroylglutamic acid PteGlu Pteroyl-L-glutamate
Brand Names	Multi-phyto Capsules Dialyvite with Zinc Mega Plex IV - Pck Mvc 9+4 Inj Prenatal Plus Vitamins Vitalife - Capsule Sodium Polysulthionate and Folic Acid UltimateCare ONE Tricare Prenatal DHA One Vita-vim With Beta-carotene - Tab Vitamin B Complex Suppl M.V.I. 12 M.V.I. Pediatric PreferaOB ONE Lexazin AxiFol Multivitamins and Multiminerals Formula Regular Tablet WesCap-PN DHA Vena-Bal DHA Palm Springs Multvit and Min Tab Vitrexyl Children's Vitamins Chewable Se-Vate 21/7 Ciferex Methazel L.C. Supplement CompleteNate Chewable Folic Acid Ctr Srt 800mcg PRENATE Restore Renate Totalvit Plus Co-Veratrol RE Nata OB Swiss One Timed Release Tab PNV Tabs 29-1 Taron-prex Prenatal L.I.P. Complex Cda-21 Vitamins With Non-medicinal Probiotic Complex Multivitamine High Potency Multivitamins & Minerals Caplets Twin Opti Pwr Vita Vim Multivitamins and Minerals Tab Virt-Care One PramLyte Taron-C DHA Central-vite 18 Essential Focalgin B PNV Prenatal Vitamin Nicomide Liqui B Complex Plus Mvc One Per Day Vitamin and Mineral Dietary Supplement Supplement De Vitamines Et Mineraux Nicadan Kanga-V Multivitamins & Minerals Dialyvite 3000 Novel Vita Children's Chewable Multivitamins With Minerals Stress B Capsules With Vitamin C Materna-tab Hi Potency B52 B Complex Tab Children's Chewable Multivitamins and Minerals Pregnancy Multivitamin Folic 5 Prenatvite Prometa Revesta Taron Forte Triveen-PRx RNF Venexa Foltx vitaMedMD Rx Plus ProFola Vitrexate Zoo Chews Plus Iron A/o-26 - Caplet Se-Natal One Maxi 10 Tab G.A.S. Complex CitraNatal 90 DHA Efferlife Multivitamins and Minerals Folvite Jenliva Omega-3 Rx Complete VitaXyme Vita-B-75 Cap Virt-Tabs OB Complete 400 Vitramyn Vitamin B Complex 100 Tab Hemocyte F RESTORA Sprinkles Taliment Cardiotek-RX Multi-vitamins With Minerals Timed Release B-complex 50 Premium Prenatal Luna Vitamin and Mineral Bar for Women Adult Infuvite Multiple Vitamins Ez-flex Preplus Ortho D Folika-MG Folica-V Vc II Infuvite Adult SetonET-EC Chewable Multiple Vitamins Plus Extra C Zatean-Pn Hematogen FA Multi Vitamin-mineral Formula PreNatal Vitamins Plus Folic Acid 1mg With C 20mg Swiss Total One TL-Fluorivite Nutra Boost TL-Select Dr. AVi MULTIVITAMIN with Zinc, Real Ginger, Lemon and Lemongrass One-A-day Advance Men's Complete Multivitamins and Minerals Tablets Timed Release Foltabs Prenatal Multi Vitamin and Mineral vitamin B.E.T. Complex Kanga-kid Multi-vitamin & Mineral Virt-Gard Somavit Brand Vitamins and Minerals Complex Super Charged Energy Fusion Plus Mebolic Noxifol-D Trinatal Ultra Formula Hh Kindervites Multi Pro FerroGels Forte N.U.T. Complex Dia-vite Prenatal Mega Antioxidant Men's Biomultiple Vitamin and Mineral Supplement Stress B-complex Plus Iron With Vitamins C&e Select-OB Plus DHA Prenatal Supplement Plus DHA Folic Acid 1mg With Vitamin C Multi-11 B Complex 25mg Vitamin Supplement Ortho Folic VP-HEME One Isotonix Multitech Vitamin Mineral Supplemen Multivitamines Plus Fer Pour Enfants (chewable Tablets) NephPlex Rx Viva CT Prenatal Cavan One B-plex Mega Balance ahoSAN Dexatran Folic Acid Injection USP Virt-Nate DHA Formula Int Balanced B50 Complex Iron Aspartate Glycinate and Polysaccharide Complex, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid One-A-day Advance Fem - Tablets 50 Plus Materna Multi Vitamin & Minerals Multiple Vitamins Tab Nicaprin PreferaOB plus DHA PreFol-DHA Prenate Star Multivitamines Et Mineraux Reguliers / Regular Multivitamins and Minerals Stress B With 1000 Mg Vitamin C B-50 Complex Children's Chewable Multi-vitamin Florafol Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops A.R.T.H. Away Formula BiferaRx bioJET Infuvite Pediatric Active OB Cedevita Sugar-free Vitamin Supplement Pregvit Shen Min Vitamin and Mineral Supplement For-2 Focalgin 90 DHA Tulivite Children's Chewable Multi Vitamins Nicadan ZX Cavan Folate DHA NEONATAL Complete Zingiber CitraNatal Medley Envirocomplex Pregvit Folic 5 Prena1 Plus Essential B Tablets Recal D TriAdvance Virt-Select PRENATAL/POSTNATAL Maxine Vitamin and Mineral Supplement Tandem - F Relnate DHA Wellness Formula RayaVit Virt-PN Multiple Vitamins With Iron Tablets Prenatal Formula Tab Vp-heme Ob Prenatrix Sandoz Folic Acid VirtPrex Kids Stuff Tablets Av-VITE FB Forte Omnivex One A Day Multiple Vit W Minerals Paire OB Plus DHA Se-Tan DHA Se-Natal Multinate DHA Extra Vitamin B Complex W C Tab NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Natal-V RX Multi-vitamin/Multi-mineral B Complex Tablets Ultra Hr Vp-ggr-B6 Vita-worth B-complex Tablets Supravite Stress Avec Vit E Et Fer INATAL Ultra Poly-Vi-Flor Gummies Folvik-D Multiple Vitamins and Minerals Stresstabs + Zinc-copper Vitranol Fe Thrivite Rx Homosistrox Capsules VIL-Rx Virt Nate Chewable Multivitamins Neonatal Plus Vitamin Prenaissance Plus Tricon Vita-Pac Genicin Vita-D Maxum Multi-vite Onccor NewFolic Vita Plex Tab Prenatvite Plus Phytopure Spark Cap Vitaflex Dietary Suplement Cedevita Plus Vitamin Supplement Super Vita Vim Multivitamins and Minerals Stress B Complex With C, E and Iron Tab Taliva Childrens Chewable Vitamins Folivane-PRx DHA P.N. Vitamin-mineral Drink Prenatal, DHA Marnatal F Magnum-75 Vitamin and Mineral Supplement Sulfzix WesCaps Divista Duet DHA VP CH Plus Children's Chewable Multivitamin Complete With Minerals Folic Acid 400mcg Tab Tianshi Vital Powder I Stress B Complex With C and E Tab Kid's Choice Children's Chewable Vitamins - Tab Vitranol Spectrum Performa Multivitamins and Minerals Tablets Folivane-OB B Complex 50+ Caplet VP-Iron-C Plus Formula Cn Co-Balamin CitraNatal Harmony 3.0 Liquid B Complex 50 Acide Folique 5 Tab Se-Plete DHA Folic-K PreGen DHA Folic Acid Plus HemeNatal OB Nephrocaps-QT Oncovite Cavan Alpha Nutrifer Plus Tablets Vitaplex Formula L.G.I. Children's Chewable Multi-vitamin Complete With Minerals Iron, Vit & Min Supp MVC-Fluoride One A Day Tab Quflora Pediatric Women's Change Formula Neutral C + Coenzyme Q10 Plus Vitamins & Minerals Pretrate PreTAB RenaPlex BioFerr 90 Multivitamins for Children Xybiotic Probiotic Support B-50 Hi Potency B Vitamins Tab Folvite-FE DermacinRx PureFolix HemeNatal OB plus DHA Flintstones W Extra C Tab Folcaps Nephrocaps Genicin Vita-S Nutra-Z OB Complete Gold Stress Tab With Iron and Vitamin E Vitazyme Balanced B-50 B-complex Vitamins, Timed Rele MYNEPHROCAPS DIALYSIS/STRESS Vitamin Supplement Folixapure Se-Tan PLUS Ortho DF Folic Acid Tab 5mg Milltrium Senior Vitamin and Mineral Supplement Active FE Tobakient Vitogen B Stress C Vit E Zinc & Cop Duet DHA 400 Multivitamins and Minerals - Complete Neomultivite Novo-folacid 5mg Super Pantoplex Multi-Vitamin With Fluoride Folic Acid 1 Mg - Tablet Revit Plus Cap T.R.I. B-plex Src Foliflex Supravite Stress Avec Vit E Cuivre Et Zinc Men's 50+ Venexa FE Ferrex 28 Complete Mega B KeyFolic Pro Pcos Citrus PreQue 10 Multipack II Gestamine Comprimes Fib-C Melts Natalvirt 90dha OB Complete DHA Multi Tabs MagneBind 400 Rx Vinacal Focalgin DSS Vinate Care FolaMax Dothelle DHA Folet One DuetDHA Complete VP CH Ultra Women's Biomultiple Vitamin and Mineral Supplement Escavite D Swiss One Niva-Fol Abavite OB Complete Prenatal Multi-force for Adults Tab Trigels-F Forte Falessa Fizz Multivitamins for Kids W C Loz Fem Time Tab Multiple Vitamins Plus Iron for Women WesCap-C-DHA Strovite One Caplets Vitrexyl plus Iron Udamin Sp FUSION Sprinkles Ventrixyl Prenate Pixie V-Natal Neonatal Vitamin Replavite Multinate DHA B-100 Hi Potency B Vitamins Tab Multi Plex II - Tab PR Natal 400 Bal-Care DHA Children's Chewable Vit and Min Tab Multi Flow Tablets Balanced B-50 B-complex Vitamins Tab Stress Complex 600 Avec Vit E Cuivre Zinc TM-Vite RX Vita Day Tab Xyzbac Olympian Multi Vit Plus Minerals Tab Master Key Multi Vitamin Multi Mineral Formula 2 Multi Vitamins & Minerals Multi B Q.T. #4 Vitamin and Mineral Dietary Supplement FerraPlus 90 Folinex Complexe B-75 Imubolic Floradix Formula Liq MaxFe Foltabs 800 Zatean-CH Homosistrol Capsules Innersource Tab PaxLyte Remedient tensioSAN Kimchi Vitamin chewable multivitamin NataChew Prenatabs FA Ultimate Tab Vital-D Rx Choice OB DHA Calcium Folic Acid Plus D Chewable Alkadrenergy Tablets Multivit with Fluoride Genicin Vita-Q Corvite Free Vitaphil 90 DHA For Kids Only Chewable Multivitamins - Tab M.V.I. Adult Nicazyme Jamp-folic Acid Body Rox Nutri-Tab OB CitraNatal DHA Animal Shapes w/Iron Chewtabs B-complex-50 Tab Complexe B 75mg Duet DHA Balanced FaBB Mag-A-folic Tab Virt-PN DHA B-100 Complex Tablets Bseltzer healthy mamaBE WELL ROUNDED BE WELL ROUNDED NovaFerrum Prenaissance Prenatal Plus Multivitamin Plus DHA MiniCaps Floriva TL-Folate Tandem OB Omniquin Concept DHA Prenavite Forte Chew.multiple Vits.with Extra C for Children Folic Acid Tab 1mg Vita-vim - Tab Virt-Vite Forte Maximum Once A Day Multiple Vitamins and Minerals Capsules Low Potency B Complex Tab Ultimate OB DHA Women's Formula Foltrate For Kids Only Chewable Multivitamins Multi-force for Women Tab Daily-Vite Fortamines 10 Capsules Vitamin B6 & B12 With Folic Acid B-100 Caps Twin G.F. Powder Vanilla Flavor Prenatal Super B Compound W 500mg Vit C Fibrik Vitafol OB Caplet Chewable Adult Multivitamins With Minerals Amerix Multivitamin Multivitamines Pour Enfants (chewable Tablets) Orange Flavored Crystal Chews Tab Nexa Plus Re Ob 90 DHA Zavara Great Day/am Formula Tab Animi-3 with Vitamin D NicAzel TriStart ONE E.S.T. Complex Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA Twin G.F. Powder Se-Care Conceive C-B Complex TL-Icon Bentivite Complexe B Compose 75 Vitamin B Compound Tab Stress Tab With Zinc, Copper and Vitamin E Stress B Complex With C,e, Zinc and Copper Vimeral Tab PRENATE Enhance Viva Kids - Tab NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Niva-Plus Nutrol-B-complex Only One - Tablet Vasculine Super B12 + Folic Acid Formula Gly Folika-D Multivitamin NESTABS Prenatal Multi-vitamin/Mineral Supplement OB Complete Petite Vita Balance 2000 Orti B FolaMed DHA Integra Plus Mega Plex III - Pck Vitafol Nano Multiple Vitamins Plus Iron - Tab Children's Chewable Tab Advanced B & T Formula Formula O.C. Prenatal Vitamins Plus Low Iron Revit Multi-vitamins and Minerals Hylazinc Florafol FE Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid Drops PreGenna Enrich Core Pack - Children Vitamin and Mineral Supplement PureFe Plus Folic Acid Inj 5mg/ml USP Natal PNV Multivitamin with fluoride Tozal Bal-Care DHA Essential Animi-3 Multitabs Folcaps Omega-3 Potassium W Folic Acid Tab Folic Acid 0.8mg Corvite 150 Lorid Dialyvite Supreme D TL-Select DHA Swical-energy 3e Age Swiss One Multivitamin and Mineral Caplet Nu-folic Nutrilite Double X Vege Swiss One Multivitamin W Chel Mins Tab Trinaz Femitab Tab PNV Tabs 20-1 Folica BE Multivitamins and Minerals for Young Men PreNexa premier Focalgin CA Vol-Plus Premium Prenatal - Tablets Folic Acid With Vitamin B12 and Vitamin C One Daily VITES CitraNatal Bloom Provida DHA Isotonix Vitamin B-folic Acid-mineral Supple One A Day Advance Fem Nutri-Tab OB plus DHA Children's Chewable Multi Vit W Iron Quflora Gummies Vinate AZ Vitamin B + C Cap Protect Cardio AF Vyo Cylate - Pwr Multivitamins and Minerals for Women Folic Acid (1mg Tablet) vitaMedMD One Rx 50 Plus Multiple Vitamins & Minerals Centratex Natalvirt FLT Multiple Vitamins Plus Iron Tab Multiple Vitamins Ferralet 90 CitraNatal B-Calm Folic Acid 1mg Gesticare DHA Amladex Multivitamins and Minerals for Young Women P.R.O. Complex Vyqua WesNatal DHA Complete Complete One-A-day - Tab CitraNatal Harmony Multi Vitamin - Mineral Complete-RF Prenatal Cholecal DF Folic Acid 0.4 Mg Tablet Acti-folic + Dibencozide Caplets Multivitamins and Minerals for Men Avon Vitadvance Multi-kids Complete EnLyte Isotonix Advanced B-complex Vitamins With Potassium and Magnesium B Stress C + Iron & Vite Se-Natal 19 Hill.vite Chela Iron Plus C,b Complex Davimet Iron Osteo Formula Folic Acid 0.4mg Dietary Supplement Neonatal19 Provida OB Hemocyte Plus Right Choice A.M. Multi Formula - Caplet Balanced B-complex Vit + Vit C&e Tab Iron Folate-F Feminique W Iron and Calcium Tab Vita-folic-B Caps Reno Caps BP Vit 3 B 50 Capsules Advanced AM PM Adult Formula 50+ Vitamin B-12 With Folic Acid Tablets Formula O-care Vitamin and Mineral Supplement Multi-12/k1 Pediatric Multi #2 FolaGent DHA RenaPlex-D B50 B Complex Tab Ziphex Phytovim Cap Neonatal DHA Surbex-500 With Iron Escavite Children's Chewable Multiple Vitamins - Tab PreferaOB One Prenatal Plus Prenate AM Vitafol Fe Plus Vitamin B Compound W Vit C 250mg Tab WellFola Lipo-B-C Tab Multivitamines Et Mineraux Junior Regulier Nitro Vites - Tab TRONVite Zatean-Pn DHA Osteo-force Dayavite Fem - Protect Irospan 24/6 Prena1 Rocky Mountain Multiple Vit and Min Mega Tab Total Living Concepts Formula One - Tab Multiple Vit Plus Iron Tab Folic Acid Tab 1mg USP Chewable Renal Caps Dialysis/Stress Vitamin Supplement Doctor's Choice Brand for Men Cool B Globucel - Methode Earthpals Children's Chewables Multi-vitamin & Mineral Tablets Hi Potency B Complex W Chelated Minerals PreNatal 19 Paramettes Adults Balanced B100 PureFe OB Plus PNV Prenatal Vitamin Plus Vitamin A Vitafol Ultra AzesChew Edge OB B-complex Tab Macuzin Mega Capsules O-Cal Prenatal Vitamin MultiVitamin with Fluoride CitraNatal Essence Multi Plex I - Tab B Complex 50 Vitamin Cap Feminex 300 Tab Mega-vim 75 With Beta-carotene - Tablets TL Gard Rx Childrens Chewable Multiple Vitamins W.iron Revitalize Multi-vitamin and Mineral Complex Mycelized Childrens Multi-vitamin Liq Prenatal Vitamins Plus Bacmin Tandem Plus Zeldana Children's Chewable Multiple Vit.plus Iron Daily Supplement Packs Folika-T One A Day Advance Adults Protect Plus SO 60 Stress Formula Tab Vitabanks Vitamin Tab Folic Acid 800mcg Tab Maintain Multiple Vitamin & Minerals Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets) Swiss One Multi Vit & Chel Min Tab Prena1 Chew Vigo Multivitamins Drops/lozenge Children's Chewable Multivitamin and Multimineral N.E.U. Complex Feonyx Folic Acid Injection, USP Natalvirt Ca Stress Formula Multivitamin Tablets USP Complete Natal DHA Hi Potency Multi Tab Natelle One Pediatric Infuvite Multiple Vitamins Extra-Virt Plus DHA FeRiva 21 7 24 Multivitamins + Minerals Folastin Prenavite Tablets Zyvit Stress Formula + Iron Tricare Prenatal Select OB Thrivite 19 Pnv-OB-dha Vege 1 Daily Tab B-Nexa Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets) PNV Prenatal Plus Multivitamin Vitamin B Complex 50 Timed Release B-complex 100 Children's Chewable Multi Vitamins With Iron Tablets Bev 29 Tab Vtb Vitamin and Mineral Supplement Vitamin B Compound W C Tab 500mg Formula D.S. Multi 12 Injection Soluvit N Complete One A Day Tab Ferotrin Dalivit Foltamin Senior Multi One Foltabs Prenatal Plus DHA TriphroCaps MI-Vite RX Multi Vitamin Plus Iron Stress B Complex With C, E & Iron Hi Potency Balanced B-100 Complex - Tab VITAFOL Gummies Prenatvite Complete Multi Vitamines - Liq Zoo Chews Super Vita-vim With Beta-carotene - Tab Nicotinamide CitraNatal Assure Corvite Chela Potassium Plus Citranatal B-calm Formula Ch. Les. Timed Release Vita-vim Srt WesNate DHA Folic Acid Tablets 0.8mg Materna - Tab Flintstones Multiple Vitamins Tab Prenatal Vitamin and Mineral Supplement Tab Folcal DHA Niaacinamide Azelaic AC TURMER FA B6 Zinc Ox Copper Vitafol-OB Plus DHA Prenatal Supplement Plus DHA Chromagen B-complex 100 Folic Acid-b12 Tab VP-Vite Rx Niferex Complex-75 Folite Mr. Tumee Multi-vitamin Folgard Multi Vitamin with Fluoride Multitam Pro Hers Vanilla Ostachol PreferaOB B-complex 50 TL-Fol 500 CitraNatal Bloom DHA Folic Acid 1 mg Vitasure UltimateCare ONE NF Daily Energy Brand B-complex Dialyvite Prenatal Vi-min Prenatal Vitamin and Mineral Supplement -tab Nata Komplete Corvite FE B-50 Complex Tab Folvite-D Tianshi Vital Powder III Prenate Chewable Virt-Bal DHA Plus Ventrixyl Fe Children's Vitamins W Iron Chewable B6, B12 & Folic Acid Multi-vitamin Tablets CyFolex EnBrace HR Multivitamins and Minerals Tablets PM Caps Folivane-Plus with Ascorbic Acid Precursors Strovite Forte Caplet Prenate Elite Chewable Multiple Vitamins for Children Rulavite DHA SetonET Super Multi Fortamines-10 Comprimes Super Stress Capsules Men's Virt-C DHA H.W. Children's Chewable Multi Vit & Mineral Folbic Multi-actin PR Natal 430 Multivitamin & Multimineral hormaSAN forte Folplex Zolate Childrens Chew Multi Vitamin Tab Stress Formula Multi-B Comp + 500mg Vit C Cap Foltrexyl Reliv So Sense Daily Vitamin Supplement Polymine Avec Zinc Et Cuivre Iron Polysaccharides Folic Acid DHA PNV-Select Stress B&c Tab Hypo Vites Tab FE C Tab Plus Iron Folate Plus Mini-B Tab Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo Se-Care Chewable Men's Multi Master Formula Time Release B 100 Compound - Tablet Extra P.N. Vitamin-mineral Drink Mix B-complex Homosismin Century Complete Kids Stuff With Iron Tablets Hsn Formula Folivane-F Q.T. Vitamin and Mineral Drink Mix Avon Nutrivance Vitamin E Plus Balanced B-50 Complex Iron Plus Tab Corvita Multra With Iron Prim - Royal P.M.T. Natural Source Spectrum With Beta Carotene Childrens Chewable Multiple Vitamins Plus Fe Orifer F Nephron FA Sodium polysulthionate and folic acid Hematogen Forte Folitin-Z Myferon 150 Forte New Chapter's D'adamo 4 Your Type Multiple for Type O B-100 Vitamin Supplement Virt-Nate M-Natal Plus TriStart FREE PreNexa Corvita 150 Multi-12 Pediatric Azesco Liqui B Complex Prefera OB plus DHA Zalvit Poly Vi Flor Chewable Tab Multiple Vitamins With Iron Triveen-Duo DHA Mega Vitaminerals Docosavit NataFort Formula Cp Cap Bear Essentials Xyzmune Multi-kid Sveets Nestabs ONE Reaphirm Plant Source DHA Vita Vim With Beta Carotene-caplet Ply Vi Sol Chewable Tab Folic D3 Prenatal and Post Partum Supplement Folic Acid Tablets 5mg FeRivaFA Dexifol Concept OB Nicotinamide Zcf Flintstones Multiple Vitamins Renate DHA NicAzel Doxy Kit PrePLUS Tricare Prenatal Compleat Prenatryl Multra Plex Balanced B-100 Timed Release Zintrexyl-C Vol-Nate Stress Forte Plus Lipotropic Factors Nutria Ferrex 150 Forte Plus M.V.I. Paediatric Iron Vitamins B6,b12,c,folic Acid Tab Nutra-clear Niron Komplete Se-Natal 19 Chewable DuetDHA Balanced DermacinRx Purefoltin Essential Vitamins and Minerals MultiVitamin with Fluoride Chewable Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Mega 13 Multivitamin Formula Vit-HA Multi Vitamin and Zinc Supplement Re Kar C Plus Vitafol Plus Av-VITE FB Balanced B 125 Srt Vol-Tab Rx Pregvit Folic 4 FeRiva FA Grand Master Formula Tab Iron Plus Manganese, B12, Folic Acid & C Multiple Vitamins & Minerals Tablets Children's Chewable Multiple Vitamins (chewable Tablets) Vp-heme Ob DHA V & M Vitamin and Mineral Supplement Childrens Chewable Tab Pregnancy Multivitamin Super Kids Chewable Multivitamin Multimineral (chewable Tablets) Energy 80 Prolonged Release Tab RE Nata Vitafol One B-Serene Rx Vp-CH-pnv WestGel DHA Pnv Ob DHA Formula F L W Fem - Control Multi-Vitamin Moms Choice Rx Xvite Macuvex Folcaps Care One TL-Care DHA Derma-force Xyzbac G Vita-B Extra Once A Day Bev B-150 Supplement De Multivitamines Infusion Arome Fruits Rouges DermaNIC One A Day Advance Adults 50+ Multivitamin with Fluoride Multi-vitamin Dietary Supplement Natafolik RE Prenatal Multivitamin with Iron Card-floe II Tab Pnv-dha Timed Release B Complex 100 Srt Complete Multivitamins and Minerals for Children Oveeza Super Stress Mega B Plus 1000mg Vit C Tab Virt-Caps Childrens Chewable Multiple Vitamins Tab Vital Be-100 Mi-Omega NF Folic acid Tl-hem 150 Multicaps Vitafol Caplet Cavan Heme OB Rogenic Tar-end Liqui Vita Sopalamine 3b Plus Duet DHA 400 ec P.N.P. Vitamin Drink C. Vit-min Formula B-complex Tablets Bio-b12 Diaplex Formula U - Tab Nexa Select Rx Prenatal Vitamin with Plant-Based DHA Prenate Essential RE FAC-x Restora Rx PrimaCare Tri-Zel Vita-Rx Diabetic Vitamin Vitamin & Mineral Formula 1 Dietary Supplement Am Caps Folika-NC PR Natal 430 ec Cavan Folate OB Hylavite PR Natal 400 ec Stress B & C Caplet Calcium PNV Neonatal Fe Virt-Advance Hi Potency Stress B Tension With C Prenatal Vitamins and Minerals Tablets Formula Inf Prenatal Plus Iron Puralor Folic Acid 0.4mg Trinatal Rx 1 DaVITE Virt-Vite Plus Folvite Inj 5mg/ml Carbassist Tablets Ferrex 150 Forte Hypnosom C.R.D.-force Prenatal Vitamin and Mineral Supplement Flintstones Multiple Vitamins Plus Iron FolaPrime Bio-fen Prenate Mini Pro His Mint Folic Acid Folcyteine B6, B12 & Folic Acid Florravite Multi-Nate 30 Stress Formula B-comp + 500mg Vit C Tab RediChew Vp-zel Iron With Vitamins Tab Multi-vitamins Pnv-VP-U iFerex 150 Forte VemaVite-PRx 2 with Fish-Based DHA WesTab Mini One Daily Vitamin and Mineral Dietary Supplement Methaver Myhephron Dialysis and Stress Supplement Hemetab Childrens Chewable Multiple Vitamins Vitafol Iron Fumarate and Aspartate, Glycinate, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid Classic Swiss One 10 Multivitamin and Mineral Tab Vitamin B12-folic Acid Folic Acid Tab 0.4mg USP PNV-Omega Stress Formula M.V.I.-12 Megavite Rx Chewable Children's Complete Multivitamins With Essential Minerals PNV Ferrous Fumarate Docusate Folic Acid Stress Vitamin B With C Complex Tablets Chewable Multiple Vit Plus Iron for Children Virt-PN Plus Dexivite Prenate DHA B Compound 50mg Tab FeRiva NuFera Flinstones Multiple Plus Iron Zatean-Pn Plus Bugs Bunny and Friends Multiple Vitamins Dotremin Harvest Of Values All B Complex Tab Mvc 9 Plus 3 Inj Spectrum 2 Cap Keylosa Prenara Adeks Tablets Ocuvel One Tablet Daily Mens Formula Cavan Prenatal For Men Stressmates Folic Acid Tab 25mg Ribotin-E Vitrexate FE CitraNatal Rx Integra F O-Cal FA multivitamin WesTab Plus Inatal Advance Folic Acid Capsules 1mg Mnps Formula Supplement Multi Enfants Tab Prenatal Supplement - Tab Folvite Tab 5mg Reebok Sopalamine/3b Plus C Leritone Antistress Sun-rype Vitaburst Vol-Care Rx B-complex With Vitamin C, Biotin, Folic Acid Stress Ctr Srt Multiple Vitamins - Tablet natelle COMPLETE Multivitamins and Minerals With Betacarotene Tablets Cavan-EC SOD DHA Multi II IV Vi Tab Multivitamin & Minerals (iron Free) PNV-First Elite OB Prenatal Multivitamin TriStart DHA Dialyvite 5000 Tandem DHA NicAzelFORTE PROTECT IRON Liquid Vit B Complex Ctr Supravite Stress Avec Vit E Vitamin B Tablets Nioxin Recharging Complex Vitachrom Gc Animal Shapes DermacinRx FoliPlus D Tricare Prenatal DHA One Rx Multivitamin Nexa Select Cifrazol Virt Vite GT Durachol Vita B Complex Tab K.L. Vitamin-mineral Natavite Folic Acid & Vitamin C For Kids Only Chewable Multivit. Plus Iron Bugs Bunny Chew Multi Vit Plus Iron Vitaphil DHA VitaPhil Aide Roxifol-D C-Nate DHA Spd Tab PureVit DualFe Plus Balanced B-100 B-complex Vitamins Tab Folika-V Super Daily No 2 Virt-Vite Vp-pnv-dha Folet DHA Childrens Chewab Vitamin W Chel Minerals Zavitrol Vitamin B Complex Tab Trinatal GT Daily Balance Tab Vitamin B12 Plus Tablets W Folic Acid Usana Megavitamin Tablets - Tab Chewable Multivitamins Plus Iron Taron BC Prenavite Forte Tablets Folditam Cavan X Stress Formula Vit B With C Complex
Indication	Folic acid is indicated for the treatment of folic acid deficiency, megaloblastic anemia, and in anemias of nutritional origins, pregnancy, infancy, or childhood.
Categories	Antianemic Preparations Autacoids BCRP/ABCG2 Substrates Biological Factors Diagnostic Agents Diet, Food, and Nutrition Dietary Supplements Drugs that are Mainly Renally Excreted Folic Acid and Derivatives Food Growth Substances Hematinics Hematologic Agents Heterocyclic Compounds, Fused-Ring Micronutrients OAT1/SLC22A6 inhibitors Pteridines Pterins Supplements Vitamin B Complex Vitamin B12 and Folic Acid Vitamins
ATC-Code	B03AE02 B03AD04 V04CX02 B03AD01 B03BB51 B03AD03 B03BB01 B03AE01 B03AD05 B03AD02
CAS number	59-30-3

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Proton-coupled folate transporter	MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHR...	unknown	modulator
Reduced folate transporter	MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITP...	unknown	modulator
Folate receptor gamma	MDMAWQMMQLLLLALVTAAGSAQPRSARARTDLLNVCMNAKHHKTQPSPE...	unknown	binder
Folate receptor beta	MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQ...	unknown	binder
Folate receptor alpha	MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPE...	unknown
Gamma-glutamyl hydrolase	MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKN...	unknown	substrate
Methylenetetrahydrofolate reductase (NADPH)	MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMR...	unknown	substrate
Dihydrofolate reductase	MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNL...	unknown	substrate
ATP-binding cassette sub-family C member 11	MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNP...	unknown	substrate
ATP-binding cassette sub-family C member 3	MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALP...	unknown	substrate
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	inhibitor
ATP-binding cassette sub-family C member 4	MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPE...	unknown	inhibitor
Broad substrate specificity ATP-binding cassette transporter ABCG2	MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKS...	unknown	substrate
Proton-coupled folate transporter	MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHR...	unknown	substrate
Solute carrier family 25 member 32	MTGQGQSASGSSAWSTVFRHVRYENLIAGVSGGVLSNLALHPLDLVKIRF...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682