G4P

GUANOSINE-5',3'-TETRAPHOSPHATE

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is present as a standalone ligand in 51 entries

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Chemical Component Summary
Name	GUANOSINE-5',3'-TETRAPHOSPHATE
Synonyms	guanosine tetraphosphate; ppGpp
Identifiers	[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-hydroxy-3-(hydroxy-phosphonooxy-phosphoryl)oxy-oxolan-2-yl]methyl phosphono hydrogen phosphate
Formula	C₁₀ H₁₇ N₅ O₁₇ P₄
Molecular Weight	603.16
Type	RNA LINKING
Isomeric SMILES	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O[P@](=O)(O)OP(=O)(O)O)O)N=C(NC2=O)N
InChI	InChI=1S/C10H17N5O17P4/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6(30-36(26,27)32-34(21,22)23)3(29-9)1-28-35(24,25)31-33(18,19)20/h2-3,5-6,9,16H,1H2,(H,24,25)(H,26,27)(H2,18,19,20)(H2,21,22,23)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
InChIKey	BUFLLCUFNHESEH-UUOKFMHZSA-N

Chemical Details
Formal Charge	0
Atom Count	53
Chiral Atom Count	6
Bond Count	55
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB04022 ?
Name	Guanosine tetraphosphate
Groups	experimental
Description	Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis.
Synonyms	Guanosine tetraphosphate Guanosine-5',3'-tetraphosphate
Categories	Guanine Nucleotides Heterocyclic Compounds, Fused-Ring Nucleic Acids, Nucleotides, and Nucleosides Nucleotides Purine Nucleotides Purines Ribonucleotides
CAS number	33503-72-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Xanthine phosphoribosyltransferase	MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFASRFAKDG...	unknown
GTPase ObgE	MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDVVFEVDE...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682