Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain.[A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.[A186143,A185981,L8717]. It is structurally and functionally related to another GABA derivative, [pregabalin].
Synonyms
Gabapentino
Gabapentina
Gabapentin
1-(Aminomethyl)cyclohexaneacetic acid
Gabapentinum
Gabapentine
Brand Names
Ratio-gabapentin
Gabapentin Kit
Neurontin
Lipritin II
Topical Nerve Pain
Dipentocaine Topical Cream Compounding Kit
Riva-gabapentin
Lipritin
Nra-gabapentin
Ran-gabapentin
PHL-gabapentin
Pentican
Gabarone
SmartRx Gaba Kit
Lido GB-300
Gralise Starter Pack
Ipg-gabapentin
Ntp-gabapentin
Van-gabapentin
Mylan-gabapentin
Taro-gabapentin
Jamp Gabapentin Capsules
Jamp-gabapentin Tablets
Gabapentin Tablets USP
Prilopentin
Gabapentin Capsules USP
Auro-gabapentin
Mint-gabapentin
Priva-gabapentin
GPL Pak
Gabacaine
Prilopentin -II
Auro-gabapentin Tablets
Pendo-gabapentin
Nu-gabapentin Capsules
Bio-gabapentin
Fanatrex
PMS-gabapentin
SmartRx Gaba-V Kit
Gaba 300-EZS
Jamp-gabapentin
Act Gabapentin
Mar-gabapentin Tabs
Cyclo/Gaba 10/300 Pack
Innoprax-5
Mar-gabapentin
Therapentin-90
Apo-gabapentin
Lidotin
Pro-gabapentin
Ag-gabapentin
Gln-gabapentin
Sig-gabapentin
Gabapal
Gd-gabapentin
Apo-gabapentin Tablets
Gralise
Gapeam Budibac
Gabapentin
ACTIVE-PAC with Gabapentin
Teva-gabapentin
Therapentin-60
Dom-gabapentin
Bci Gabapentin
Gabapentin Capsules
Indication
In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older.[L8717] In Europe, gabapentin is indicated for adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in patients 6 years of age and older and as monotherapy in patients 12 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.[L8732]
Categories
Acids, Acyclic
Acids, Carbocyclic
Amines
Amino Acids
Amino Acids, Peptides, and Proteins
Aminobutyrates
Analgesics
Anti-epileptic Agent
Anticonvulsants
Butyrates
Central Nervous System Agents
Central Nervous System Depressants
Cyclohexanecarboxylic Acids
Cyclohexanes
Cycloparaffins
Decreased Central Nervous System Disorganized Electrical Activity
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
