Chemical Component Summary | |
|---|---|
| Name | GENISTEIN |
| Synonyms | 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 4',5,7-TRIHYDROXYISOFLAVONE; PRUNETOL; GENISTEOL |
| Identifiers | 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one |
| Formula | C15 H10 O5 |
| Molecular Weight | 270.237 |
| Type | NON-POLYMER |
| Isomeric SMILES | c1cc(ccc1C2=COc3cc(cc(c3C2=O)O)O)O |
| InChI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H |
| InChIKey | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 30 |
| Chiral Atom Count | 0 |
| Bond Count | 32 |
| Aromatic Bond Count | 18 |
Drug Info: DrugBank
| DrugBank ID | DB01645? |
|---|---|
| Name | Genistein |
| Groups | investigational |
| Description | An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, genistein has antihelmintic activity. It has been determined to be the active ingredient in <I>Felmingia vestita</I>, which is a plant traditionally used against worms. It has shown to be effective in the treatment of common liver fluke, pork trematode and poultry cestode. Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties. It has been investigated in clinical trials as an alternative to classical hormone therapy to help prevent cardiovascular disease in postmenopausal women [A14417]. Natural sources of genistein include tofu, fava beans, soybeans, kudzu, and lupin. |
| Synonyms |
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| Brand Names |
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| Indication | Currently Genistein is being studied in clinical trials as a treatment for prostate cancer. |
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| CAS number | 446-72-0 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Nuclear receptor coactivator 1 | MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELL... | unknown | |
| Estrogen receptor alpha | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPA... | unknown | |
| Nuclear receptor coactivator 2 | MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELA... | unknown | |
| Steroid hormone receptor ERR2 | MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALG... | unknown | agonist |
| Steroid hormone receptor ERR1 | MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGH... | unknown | agonist |
| View More | |||
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| Pharos | CHEMBL44 |
| PubChem | 5280961 |
| ChEMBL | CHEMBL44 |
| ChEBI | CHEBI:28088 |
| CCDC/CSD | GENIST01, ZIKPIU01, ZIKPIU, GENIST, EJEQER, EJEQUH, EZEJOK, YIKRAN, BOLBAH, OTIMUC, GENIST02, OQIWOD, CANPIU |
| COD | 7211144, 7211143, 2019219 |
