GSP

5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

Find entries where: GSP

is present as a standalone ligand in 133 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 2 entries

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Chemical Component Summary
Name	5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Identifiers	[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] dihydroxyphosphinothioyl hydrogen phosphate
Formula	C₁₀ H₁₆ N₅ O₁₃ P₃ S
Molecular Weight	539.246
Type	NON-POLYMER
Isomeric SMILES	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=S)(O)O)O)O)N=C(NC2=O)N
InChI	InChI=1S/C10H16N5O13P3S/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKey	XOFLBQFBSOEHOG-UUOKFMHZSA-N

Chemical Details
Formal Charge	0
Atom Count	48
Chiral Atom Count	6
Bond Count	50
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB01864 ?
Name	5'-Guanosine-Diphosphate-Monothiophosphate
Groups	experimental
Description	Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.
Synonyms	gamma-Thio-GTP guanosine 5'-[gamma-thio]triphosphate Guanosine 5'-(gamma-S)triphosphate GTP gamma S Guanosine 5'-O-(3-thiotriphosphate) 5'-Guanosine-Diphosphate-Monothiophosphate
Categories	Guanine Nucleotides Guanosine Triphosphate Nucleic Acids, Nucleotides, and Nucleosides Nucleotides Purine Nucleotides Ribonucleotides Sulfur Compounds Thionucleotides
CAS number	37589-80-3

Drug Targets

Name	Target Sequence	Pharmacological Action
ADP-ribosylation factor 6	MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVE...	unknown
Protein-glutamine gamma-glutamyltransferase E	MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGS...	unknown
Cell division protein FtsZ	MTPPHNYLAVIKVVGIGGGGVNAVNRMIEQGLKGVEFIAINTDAQALLMS...	unknown
Ras-related protein Rab-11A	MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFAT...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682