HCY

(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

Created:	2007-10-13
Last modified:	2021-03-01

Find Related PDB Entry
13 entries where HCY is found as a standalone ligand

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	7
Bond Count	59
Aromatic Bond Count	0

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	(11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms	CORTISOL
Systematic Name (OpenEye OEToolkits)	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Formula	C₂₁ H₃₀ O₅
Molecular Weight	362.46
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(CO)C3(O)C2(CC(O)C4C1(C(=CC(=O)CC1)CCC4C2CC3)C)C
SMILES	CACTVS	3.341	C[C]12CCC(=O)C=C1CC[CH]3[CH]4CC[C](O)(C(=O)CO)[C]4(C)C[CH](O)[CH]23
SMILES	OpenEye OEToolkits	1.5.0	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Canonical SMILES	CACTVS	3.341	C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
Canonical SMILES	OpenEye OEToolkits	1.5.0	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O
InChI	InChI	1.03	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	InChI	1.03	JYGXADMDTFJGBT-VWUMJDOOSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00741 ?
Name	Hydrocortisone
Groups	vet_approved approved
Description	Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Synonyms	Hydrocortisonum Hydrocortisone 11beta-hydrocortisone Kendall's compound F 11β-hydrocortisone Cortisol 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione (11β)-11,17,21-trihydroxypregn-4-ene-3,20-dione 4-pregnen-11β,17α,21-triol-3,20-dione 17-Hydroxycorticosterone Reichstein's substance M Hidrocortisona
Brand Names	Harris Teeter Anti-Itch Cortisone 10 Intensive Moisture Creme Maximum Strength Hydrocortisone Cream Beard Medicated Cremo Cortizone 10 Plus Maximum Strength Hydrocortisone Plus Moisturizing Aloe Hydroxym Cream Bioelements Immediate Comfort Hydrocortisone Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone OLIVIA QUIDO FIRM and FADE I CVS Anti itch Rephresh Cooling DG Health Hydrocortisone Maximum Strength Pharmaskincare Acnecare Cream Crane Safety Hydrocortisone Insect Bite Relief Herb Street Anti-Itch Stick Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension Rodan and Fields Soothe Equate Hydrocortisone FixMySkin Healing Balm Vanilla Fragrance Hydrocortisone 1 Apres Peel Soothing Balm Calmurid HC Crm Dermoscribe Seborrheic Dermatitis Zims Advanced Crack Creme With Hydrocortisone Publix hydro plus Cortisone 10 Sensitive Skin Creme Assured Cooling Itch Relief Well at Walgreens Proctozone-HC Up and Up anti itch Cortizone 10 Itch Relief Massaging Rollerball CliniCalm Aquaphor Itch Relief Meijer Max. Strength Anti-Itch Cream Intensive Healing Formula Piyanping antiitch BudPak Anti-Itch Basic Care Hydrocortisone Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Hydrocortisone Cream 1% Texacort Intensive Healing Eczema Corticol-Aloe CeraVe Anti-Itch Hydrocortisone with Aloe Gelmicin Hydrocortisone with Aloe Hydrocortisone Cream 1% with Aloe Vera Loesch Anti-Itch Therapy Neomycin and Polymyxin B Sulfates and Hydrocortisone Health Mart Pharmacy Hydrocortisone Maximum Strength Plus 12 Moisturizers Exchange Select Hydrocortisone Rugby Hydroskin Cortaid Maximum Strength Dr. Sheffield Hydrocortisone Anti itch Anti itch TrueLipids Anti-Itch Barrier Harris Teeter Maximum Strength Anti-Itch Winco Maximum Strength Hydrocortisone Aveeno Hydrocortisone Anti Itch AFASSCO 1% Hydrocortisone Anti-Itch Bencort Neo-poly-bac Hydro Alacort Ala-Scalp Cortizone 10 for Psoriasis Good Neighbor Pharmacy Hydrocortisone with Aloe Cipro Avedana Hydrocortisone Cream with Aloe Scarguard MD Physicians Formula CVS Health Maxium Strentgh Cortisone FixMySkin HEALING LIP BALM unflavoured 999 Itch Relieving S-Oint HYDROCORTISONE 1% Duane Reade hydrocortisone Good Neighbor Pharmacy Anti Itch UEC Medical Anti-Itch Up and Up Hydrocortisone Anti Itch Vioform Hydrocortisone Hydroxate Gel Intensive Healing Anti Itch Leader Hydrocortisone With Aloe Sterex Crm Plus Meijer Anti Itch Anti-Itch Scalp Relief Maximum Strength Cipro HC Otic Suspension Freds Hydrocortisone with Aloe Neomycin and Polymyxin B Sulfates, Bacitracin Zinc and Hydrocortisone Sarna Whipped Foam DermaCort Anti-itch Neosporin Eczema Essentials Anti Itch Hydrocortisone Meijer Maximum Strength Anti-itch Cream Ultra Moisturizing Formula 1oz 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydrocortisone With Aloe Shopko Hydrocortisone With Aloe Hydrocortisone Continuous Kera HC Hycort Retention Enema 100mg/60ml Cipro HC Hydrocortisone Anti Itch Hydrocortisone Cream 0.5% Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% Alumier MD Post Procedure Kit with Hydrocortisone Up and Up Intensive Healing Welly Itch Fix Good Neighbor Pharmacy Hydrocortisone meijer Hydrocortisone Plus 12 Moisturizers Anusol HC Freds Hydrocortisone Plus 12 Moisturizers Quality Choice Itch Relief Maximum Strength Anti-Itch Medi-First Hydrocortisone Face Values Hydrocortisone With Aloe Nizoral Scalp Itch Relief Duane Reade hydrocortisone plus 12 moisturizers Monistat Complete Care Instant Itch Relief Emo Cort Sol 2.5% USP Smart Sense Anti Itch Alumier MD Intensive Recovery DG Health Hydrocortisone Signature Care Anti Itch Total Relief Hydrocortisone and Acetic Acid Hydrocortisone Plus 10 Moisturizers Medi-First Hydrocortisone 1% CVS Pharmacy Anti-itch Good Neighbor Pharmacy Hydrocortisone With Aloe for Sensitive Skin Cortizone 10 Cooling Relief FIRST Dukes Mouthwash Compounding Meijer Maximum Strength Anti-itch Neosporin Essentials Trial Pack FixMySkin HEALING BODY BALM Fragrance-Free Hydro Skin Proctol Ointment Cortomycin Dermasorb AF Complete Kit Rugby Hydrocortisone With Aloe Formu Care Anti Itch maximum strength Care One hydrocortisone maximum strength Mycozyl HC ATOPALM Moisturizing Hydrocortisone Hydro Ear Hydrocortisone maximum strength SKIN A COOL Hydrocortisone Anti-Itch Maximum Strength Gold Bond Medicated Anti-itch Cream Intensive Formula Texacort Solution 1% HEM-EASY RELIEF Herbal Anti-Itch MAXIMUM ITCH RELIEF Oto End 10 Sunmark Hydrocortisone with Aloe Maximum Strength Welly First Aid Kit ECOLAB Hydrocortisone Cream Anti-Itch Regular Strength Anti Itch Oti Rx Scalpicin Maximum Strength Harris Teeter Anti-Itch Cooling Relief Family Wellness Max Strength 1 Hydrocortisone Cream Shopko Hydrocortisone Plus 12 Moisturizers Maximum Strength Hydrocortisone Plus 12 Moisturizers Maximum Strength Hydrocortisone Crm 1% Casporyn HC Caring Mills Hydrocortisone Colocort Hydrocortisone Micro Smart sense Hydrocortisone Hydrocortisone 2.5% / Ketoconazole 2% Hydrocortisone With Aloe Maximum Strength ShopRite Hydrocortisone Hydrocortisone Cream Intensive Healing Healthy Accents Cortisone Maximum Strength Alcortin Vosol HC Shopko Hydrocortisone Intensive Healing Formula Oticin HC Ear Drops Selsun Blue Scalp Itch Treatment Up and Up Hydrocortisone One Per Cent Walgreens Hydrocortisone Plus 12 Moisturizers Cicatricure Ultra Moisturizing Proctosol-HC Refuge HC Cortizone 10 Hydratensive Healing Anti Itch Scalpicin Anti-Itch Maximum Strength Berkley and Jensen Hydrocortisone Basic Case Hydrocortisone Anti-Itch Family Wellness Hydrocortisone Dermarest Eczema Medicated Quality Choice Anti Itch with Aloe Quality Choice Hydrocortisone Maximum Strength Careone Anti Itch Cho-A Care Lot 1% AVON HeXashield Anti Itch Cream with Healing Aloe Post peel Protectant Vitality Institute Hydrocortisone with aloe Soothe Rodan Fields Emo Cort Lotion 2.5% Vioform Hydrocortisone Mild Hydrocortisone Butyrate 1% Hydrocortisone Shoprite Hydrocortisone Audiologist Anti-itch Good Neighbor Pharmacy Hydrocortisone Plus 12 Moisturizers Eczema Skin Mushatts N9 H-Releve Anti-Itch Hemorrodil Unguento Plus 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% glo SKIN BEAUTY Remedy Gel sunmark Hydrocortisone Quality Choice Hydrocortisone NEOMYCIN and POLYMYXIN B SULFATES and HYDROCORTISONE Preparation H Hydrocortisone Ti-U-lac HC Lotion Berkley and Jensen Anti Itch meijer Itch and Rash Relief Hydrocortisone with Aloe Maximum Strength WinCo Foods Hydrocortisone Cream Intensive Healing Proctozone HC Cortenema Sus 100mg/60ml Proctosedyl Sup Up and Up anti itch maximum strength Hydrocortisone 1% with healing aloe Duane Reade HeXashield Anti Itch Cream with Healing Aloe Good Sense Anti Itch Family Wellness Maximum Strength Hydrocortisone Cortizone 10 Anti-itch for Diabetics Skin Hydrocortisone 0.5% / Hydroquinone 6% Western Family HydroCortisone Plus 12 Moisturizers CVS Maximum Strength Anti-Itch Cream Welly Superhero Supplies Kit Hydrocaine Dermaquest Skin Therapy Post-Skin Resurfacing Balm Hydrocortisone D Hydrocortisone, Iodoquinol Cooling Itch Relief Rite Aid Cortisporin Ophthalmic Quadrydern Barmicil Plus CVS Health Hydrocortisone Anti Itch Proctocream HC Live Better Hydrocortisone with Aloe NU-DERM Tolereen Anti-pruritic PS-2896 Hydrocortisone Cream 1%, 0.9g Dr. Throwers Hydrotet Monistat Soothing Care Itch Relief Psoriasin Itch Control H Plus Holdings Nourishing Mycozyl HC Cream Gel Hydroxym Maximum Strength Cortisone Schein Hydrocortisone Aveeno Hydrocortisone Anti-itch Cream Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Ala Quin Green Guard Maximum Strength Hydrocortisone Pramoxine-HC Glytone soothe calming Cortizone 10 Intensive Healing for Eczema OLIVIA QUIDO FIRM and FADE II Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Harris Teeter Anti-Itch Intensive Healing Cortisone Cream Intensive Healing Anti-Itch with Aloe ProCure Hydrocortisone Cream Plus Theracort Proctocort CVS Anti-Itch Hydrocortisone Home PapKit Discount Drug Mart Anti-itch Scalpicin Scalp Itch Medication Maximum Strength Triple Antibiotic HC Sterex Lot Plus Itch and Bite Relief First Aid Kit Ana Cool Rapid Soothing Cooling Formula Cortisone Plus Aloe Maximum Strength Meijer Intense Healing Aloe Cort Kirkland Signature Hydrocortisone Plus Maximum Strength Antibiotic Ear (Neo/Polym/HC) Cortibalm Hydrocortisone HC Equate Hydrocortisone Topical Cortaid Intensive Therapy Cooling Family Care Hydrocortisone Cortizone 10 Ultra Soothing Creme HydroSKIN Alkindi Sprinkle CVS Cortisone Dr Lift Soothing Cream Pharmaskincare Brightening Dermarelief Cream Preparation H Soothing Relief Anti-itch Cortaid 12-Hour Advanced Anti-Itch Ketocon Fulton Street Market Anti itch Proctosedyl Suppositories Quality Choice Anti-Itch Weeks and Leo Anti-itch Cortizone 10 Easy Relief Dermoscribe Ichybum KAISER PERMANENTE Hydrocortisone Poison Oak and Ivy Regular Strength Hydrocortisone Cream Petrocort Antipruritic Lip 21 Proctosedyl Health Mart Pharmacy Hydrocortisone Maximum Strength with Aloe Cortisone 10 Overnight Creme Cortisone Hydrocortisone Regular Strength Hydrocortisone Intensive Healing Formula Poison Oak Equate Hydrocortisone Intensive Healing Formula Shopko Hydrocortisone TopCare Hydrocortisone 1% with Aloe Hydrocortisone Crm 0.5% Odan Proctomyxin HC Suppositories Instant Cooling Itch Relief CVS OREAD GOLD Anti-Itch Foam Clindamycin 1% / Hydrocortisone 2.5% / Niacinamide 4% Hydrocortisone Maximum Strength with Aloe Procto-Pak Careone Hydrocortisone 1 Maximum Strength FIRST Marys Mouthwash Compounding S-Cream HYDROCORTISONE 1% TheraCare Hydrocortisone Cream Premier Value Hydrocortisone Plus 12 Moisturizers Publix Hydro Cortef Anti Itch Maximum Strength Plus Aquacort Lotion 2.5% Pediotic Meijer Anti Itch Cream Plus Acetasol HC Loesch HC-10 ANTI-ITCH THERAPY Cooling Itch Relief Proctol Suppositories Dermazene Sandoz Hydrocortisone Meijer Maximum Strength Anti-itch Cream with Aloe Lucky SuperSoft MAXIMUM STRENGTH Hydrocortisone 1 Plus 10 Post Treatment Balm Signature Care Hydrocortisone Makesense Maximum Strength Avedana Hydrocortisone Maximum Strength Shopko Maximum Strength Equaline Anti Itch Proactiv Solution Anti-Itch Scalp Cortizone-10 Soothing Aloe Creme Cortisone maximum strength Dg Health Hydrocortisone Aquanil HC Natureplex Hydrocortisone Hydro Rexall Hydrocortisone 1 Hydrocortisone Iodoquinol Quatriderm Anti-itch Cortizone 10 Intensive Healing Feminine Itch Relief Hydrocortisone Plus Odan Proctomyxin HC ProCure Hydrocortisone Plus Calendula Quality Choice Anti Itch Hydrocortisone Maximum Strength Hytone Premier Value Hydrocortisone WINCO Hydrocortisone Meijer Maximum Strength Anti-itch Cream wiith Aloe TopCare Hydrocortisone Intensive Healing Formula DG health hydrocortisone Hydrocort Pediadermics Eczema 2 Pediaderm HC Leader Hydrocortisone Hydrocortisone Plus 12 Moisturizers Auro-hydrocortisone Up and Up Hydrocortisone Shopko Hydrocortisone Maximum Strength Corti-Sav Hydrocortisone Ultra Strength Vioform + Hydrocortisone Cortate Crm 1% Itch relief Cream HydroCortisone Intensive Healing Formula 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Harris Teeter Anti-Itch with Aloe Hydrocortisone Anti-Itch Cortizone 10 Feminine Itch Relief SAFEWAY Hydrocortisone Plus 12 Moisturizers Rexall Anti Itch Maximum Strength Relief Hydrocortisone Ointment 0.5% Rite Aid Cortisone Quatriderm Creme Nf CareOne Anti Itch Hydrocortisone Rectal Suspension (Retention) Medi-First Plus Hydrocortisone Post-Treatment Repair Cream CeraVe Developed with Dermatologists Anti Itch Cortizone 10 Cooling Cream Anti-Itch Sandoz Cortimyxin Maximum Strength Cortisone Cream with Aloe Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Odan-spor-HC Healerz for Itches Hydrocortisone Cream Yes To Coconut Eczema Relief Welly Adventure First Aid Kit WinCo Maximum Strength Hydrocortisone Cortizone 10 Hydratensive Soothing Anti Itch Barmicil Anti-itch OLP Hydrocortisone 1% TrueLipids 1% Hydrocortisone Barrier Cream Emo Cort Cream 2.5% Medi-Cortisone with Aloe Aveeno Hydrocortisone ANTI-ITCH Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% HydrocortisoneLotion Thera Plus Cortane-B Instant Cooling Itch Relief Members Mark Hydrocortisone Xpect Hydrocortisone 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% CVS Maximum Strength Feminine Anti-Itch Cream Itch Relief CVS Cools Itch Fast Caldecort Cortizone 10 Sensitive Skin Anti-itch Creme Tecnu Corticool Welly Excursion First Aid Kit NeilMed Anti-Itch Itch and Rash Cream HydroSkin Equaline Anti Itch Maximum Strength Healing Tree Calming Anti-itch Pharmaskincare Multi-Gly Skin Relief Cream TopCare Hydrocortisone Cortaine -B Aqueous First Aid Only Hydrocortisone 1% Anti-Itch Neomycin, Polymyxin B Sulfates and Hydrocortisone Cortate Ont 1% FixMySkin Healing Balm Unflavored Smart Sense Hydrocortisone Sunmark Hydrocortisone Plus Western Family HydroCortisone Dr H Stabilizer Cvs Hydrocortisone With Aloe Zims Advanced Hydrocortisone Continuous With Organic Arnica and Aloe Alkindi TopCare Hydrocortisone Plus 12 Moisturizers Cortizone 10 Poison Ivy Relief Pads Meijer Anti-itch with Aloe Itch Stuff Cortenema Thera plus Anti-itch with aloe Hydrocortisone Family Wellness Maximum Strength Hydrocortisone Sarna HC Hydrocortisone Ointment 1% Anti-itch Feminine Care Cortizone 10 Cooling FixMySkin Healing Balm Vanilla Flavor Cortisporin Blue-Emu Anti-Itch Cream Maximum-H Theraplex AIM Anti-Itch Moisturizing Cream Itch Fixer Market Basket Anti-Itch Cream Plus Hydrocortisone anti-itch plus Cortizone 10 Overnight Itch Relief meijer Hydrocortisone Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Anti-Itch Scherer Labs Cortisone Maximum Strength Our Family Hydrocortisone with Aloe Aloe Cort Calming Cream Topcare Hydrocortisone Smart Sense Anti Itch Maximum Strength Anti Itch Maximum Strength Efmody Up and Up Anti Itch Vanoxide HC Cortizone 10 Water Resistant Cortizone 10 Hydrocortisone 2.5% / Levocetirizine Dihydrochloride 2% Anti-itch Maximum Strength Hydrocortisone Cream with Aloe Quality Choice Maximum Strength Anti Itch FixMySkin Healing Balm Fragrance-Free Advanced Hydrocortisone Scarguard MD Hydrocortisone Maximum Strength with aloe Maximum Strength Cortizone 10 Quick Shot 360 Continuous Welly Human Repair Kit SeaCalm Skin Itch Relief Instant Cooling Proctosedyl Ointment signature care Hydrocortisone Atopalm Maximum Strength Anti-Itch Rite Aid anti-itch Hydrocortisone Cream 0.5% USP Plenadren hydrocortisone Iodoquinol Hydrocortisone Cream USP 0.5% TheraCare Maximum Strength 1% Hydrocortisone Xerese Cortizone 10 Intensive Healing Family Care Anti-Itch Procto-Med HC Care One Hydrocortisone Maximum Strength Viniferamine Hydrocortisone Cream Barriere HC 1% Dermarest Dricort 0.5% Hydrocortisone Anti-itch Rexall Hydrocortisone Plus Moisturizers Hydrocortisone 1% in Absorbase
Indication	Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Categories	11-Hydroxycorticosteroids 17-Hydroxycorticosteroids Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Inflammatory Agents Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Corticosteroid Hormone Receptor Agonists Corticosteroids Corticosteroids Acting Locally Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Weak (Group I) Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2B6 Inducers Cytochrome P-450 CYP2B6 Inducers (strength unknown) Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strength unknown) Cytochrome P-450 CYP2C8 Inducers Cytochrome P-450 CYP2C8 Inducers (strength unknown) Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (strength unknown) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Substrates Dermatologicals Fused-Ring Compounds Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hydrocortisone and derivatives Hydroxycorticosteroids Hyperglycemia-Associated Agents Immunosuppressive Agents Intestinal Antiinflammatory Agents Nasal Preparations OAT3/SLC22A8 Substrates Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein inducers P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Sensory Organs Steroids Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives
ATC-Code	S01CB03 A01AC03 S01BA02 S01CA03 D07AA02 S01BB01 D07XA01 D07BA04 S02CA03 A07EA02 S02BA01 R01AD60 H02AB09 D07CA01 S03CA04 C05AA01
CAS number	50-23-7

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown	agonist
Annexin A1	MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAA...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 3A7	MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNA...	unknown	substrate
Cytochrome P450 11B1, mitochondrial	MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWL...	unknown	substrate
Cytochrome P450 11B2, mitochondrial	MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWL...	unknown	substrate
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inducer
Aldo-keto reductase family 1 member D1	MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYR...	unknown	substrate
3-oxo-5-alpha-steroid 4-dehydrogenase 2	MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPAR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase type 2	MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQR...	unknown	substrate
11-beta-hydroxysteroid dehydrogenase 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	substrate
Cytochrome P450 2A6	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLN...	unknown	inducer
Cytochrome P450 1B1	MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSA...	unknown	inducer
Cytochrome P450 2B6	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRG...	unknown	inducer
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	inducer
Cytochrome P450 2C19	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV...	unknown	inducer
Sex hormone-binding globulin	MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPAVHLSNG...	unknown	binder
Corticosteroid-binding globulin	MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSL...	unknown	binder
ATP-dependent translocase ABCB1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	substrate,inducer
Solute carrier organic anion transporter family member 1A2	MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQ...	unknown	inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL389621
PubChem	5754
ChEMBL	CHEMBL389621
ChEBI	CHEBI:17650
CCDC/CSD	ZZZPNG01, ZZZPNG03, GOGQEZ, CORTMS01, COWNEI, CORTMS, ZZZPNG02, CORTPY, SACWAY01, SACWAY, ZZZPNG04
COD	1559402