HCZ

6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Created:	2009-08-06
Last modified:	2011-06-04

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4 entries where HCZ is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	25
Chiral Atom Count	0
Bond Count	26
Aromatic Bond Count	6

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Chemical Component Summary
Name	6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Systematic Name (OpenEye OEToolkits)	6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
Formula	C₇ H₈ Cl N₃ O₄ S₂
Molecular Weight	297.739
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	11.02	O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)NCN2)N
SMILES	CACTVS	3.352	N[S](=O)(=O)c1cc2c(NCN[S]2(=O)=O)cc1Cl
SMILES	OpenEye OEToolkits	1.7.0	c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
Canonical SMILES	CACTVS	3.352	N[S](=O)(=O)c1cc2c(NCN[S]2(=O)=O)cc1Cl
Canonical SMILES	OpenEye OEToolkits	1.7.0	c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
InChI	InChI	1.03	InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChIKey	InChI	1.03	JZUFKLXOESDKRF-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB00999 ?
Name	Hydrochlorothiazide
Groups	vet_approved approved
Description	Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444]
Synonyms	HCTZ Hydrochlorothiazide Hidroclorotiazida Hydrochlorothiazidum
Brand Names	Exforge HCT Apo-candesartan/hctz Apo-losartan/hctz LOSARTAN POTASSIUM and HYDROCHLOROTHIAZIDE Ser-Ap-Es Valsartan HCTZ Inderide-40 Tab Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Van-irbesartan-hctz Hydrodiuril Tab 100mg Ag-olmesartan Hctz Viskazide Losartan potassium and Hydrochlorothiazide Irbesartan Hydrochlorothiazide Bms PMS-irbesartan-hctz Lisinopril/HCTZ Lisnopril/hctz (type P) Taro-ramipril Hctz Esidrix Ifirmacombi Hydropres 25 Tab Hydrochlorothiazide 50 Accel-candesartan/hctz Bisoprolol Fumarate and Hydrochlorothiazide Mar-candesartan / Hctz Neo Codema 25mg Zestoretic Jamp Telmisartan-hct Hydrochlorothiazide Olmesartan Medoxomil-hydrochlorothiazide Copalia HCT Losartan Potassium and Hydrochlorothiazide Ava-valsartan HCT Benazepril hydrochloride and hydrochlorothiazide Teva-valsartan/hctz Ser-AP-ES Tab Teva-triamterene/hctz Ava-lisinopril HCT Hydrochlorothiazide Tablets 25mg Pendo-telmisartan-hctz Penta-triamterene Hctz Tablets Hyzaar DS Micardisplus Sandoz Losartan HCT DS Mylan-valsartan Hctz Hydralazine HCl and Hydrochlorothiazide Diovan-hct Amturnide Act Telmisartan/hct Olmesartan Medoxomil/hctz Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/25 mg Capozide Enalapril Maleate/hctz Losartan/hctz Atacand HCT Avalide Methyldopa and Hydrochlorothiazide Mint-losartan/hctz DS Mylan-lisinopril Hctz Olmesartan Medoxmil and Hydrochlorothiazide PMS-hydrochlorothiazide Teva-quinapril/hctz Aldactazide 25 Losartan potassium and hydrochlorothiazide Losartan-hctz Dom-hydrochlorothiazide Candesartan Cilexetil and Hydrochlorothiazide Tablets Prz-olmesartan/hctz Losartan Potassium HCTZ Bio-hydrochlorothiazide Aldactazide Quinapril and Hydrochlorothiazide 20/12.5 Act Irbesartan/hct Gln-olmesartan Hctz Timolide Tab PMS-valsartan-hctz Karvezide Apo-valsartan/hctz Amlodipine, Valsartan, Hydrochlorothiazide Pro-triazide Amlodipine, Valsartan, and Hydrochlorothiazide Candesartan HCT Penta-amiloride Hctz Tablets Apo Triazide Mint-losartan/hctz Olmesartan Medoxomil / Hydrochlorothiazide Van-losartan-hctz Hyzaar Apo Methazide 15 Teva-telmisartan Hctz PMS-olmesartan-hctz Atacand Plus Sandoz Valsartan HCT Q-valsartan Hctz Dafiro HCT Alti-amiloride Hctz Hydropres 50 Tab Captopril and Hydrochlorothiazide Enalapril/hctz Irbesartan and Hydrochlorothiazide Monopril-hct Zinda-candesartan/hydrochlorothiazide Losartan HCT Kinzalkomb Amlodipine, Valsartan and Hydrochlorothiazide Riva-amilzide 5/50 mg Lotensin HCT Aldoril 15 Tab Imprida HCT Olmesartan Medoxomil / Amlodipine Besylate / Hydrochlorothiazide Tribenzor Apo-cilazapril/hctz Propranolol Hydrochloride and Hydrochlorothiazide Mylan-irbesartan Hctz Teva-lisinopril/hctz (type P) Maxzide-25 Nu-lisinopril/hctz Actelsar HCT Lopressor HCT Hydrochlorothiazide 25mg Tablets PMS-candesartan-hctz Benazepril Hydrochloride and Hydrochlorothiazide Fosinopril Sodium and Hydrochlorothiazide Telmisartan-hctz Urozide Olmesartan Medoxomil and Hydrochlorothiazide Metoprolol Tartrate and Hydrochlorothiazide Teva-cilazapril/hctz Ramipril-hctz Sandoz Telmisartan HCT Dyazide Apo-telmisartan/hctz Ava-hydrochlorothiazide Hydrodiuril Tab 25mg Quinapril and Hydrochlorothiazide 20/25 Irbesartan HCT Losartan HCT DS Triamterene and Hydrochlorothiazide Gd-quinapril Hctz Moexipril Hydrochloride and Hydrochlorothiazide Alembic-telmisartan/hctz Moduret Bisoprolol Fumarate Hydrochlorothiazide Teva-enalapril/hctz Novamilor Auro-quinapril Hctz Olmesartan/hctz Vaseretic Teva-irbesartan Hctz Metoprolol Tartrate and Hydrochlorothiazide 50 mg-25 mg OLMESARTAN MEDOXOMIL and HYDROCHLOROTHIAZIDE Teveten HCT Neo Codema 50mg Lisinopril and Hydrochlorthiazide Teva-candesartan/hctz Ntp-irbesartan/hctz Mylan-candesartan Hctz Teva-losartan/hctz Sandoz Olmesartan Hctz Telmisartan and Hydrochlorthiazide Auro-candesartan HCT Mint-irbesartan/hctz Mint-hydrochlorothiazide Lisinopril and Hydrochlorothiazide Inderide Ava-irbesartan/hctz Mylan-amilazide Teva-spironolactone/hctz Ran-irbesartan Hctz Micardis HCT Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/5/12.5 mg Apo Methazide 25 Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/12.5 mg Dyazide Tab Jamp-irbesartan and Hydrochlorothiazide Aldoril 25 Tab Nra-olmesartan Hctz Quinapril HCL and Hydrochlorothiazide Metoprolol Tartrate and Hydrochlorothiazide 100 mg-50 mg Ntp-lisinopril/hctz (type Z) Rasilez HCT Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 40/10/25 mg Microzide Losartan Pot/hctz PMS-telmisartan-hctz Accuretic Metoprolol Tartrate and Hydrochlorothiazide 100 mg-25 mg Valsartan and Hydrochlorothiazide PMS-dopazide-25 Tab Benazepril and Hydrochlorothiazide Losartan/hct Jamp Quinapril / Hctz Jamp-losartan Hctz Inderide-80 Tab Taro-telmisartan Hctz Quinapril and Hydrochlorothiazide Triamterene hydrochlorothiazide Quinapril Hydrochloride/hydrochlorothiazide Telmisartan Hctz Sandoz Irbesartan HCT Diuchlor H Tab 50mg Maxzide Nu-amilzide 5/50 Mg Tab Candesartan Cilexetil and Hydrochlorothiazide Candesartan Cilexetil-Hydrochlorothiazide Apo-olmesartan/hctz Tolucombi Irbesartan/hctz Altace HCT Moexipril hydrochloride/hydrochlorothiazide Coaprovel Diovan HCT Quinapril Hydrochloride and Hydrochlorothiazide Sandoz Losartan HCT Dom-irbesartan-hctz Auro-telmisartan Hctz Quinapril and Hydrochlorothiazide 10/12.5 Septa-losartan Hctz Nra-candesartan Hctz Irbesartan/hydrochlorothiazide Teva Enalapril Maleate and Hydrochlorothiazide Telmisartan and Hydrochlorothiazide Hydrochlorothiazide 50mg Tablets Valsartan HCT Hydrochlorothiazide 100mg Tablets Ach-olmesartan Hctz Ratio-losartan Hctz Lisinopril and hydrochlorothiazide PMS-dopazide 15 Tab Apo-spirozide Tab Apo-ramipril/hctz Enalapril maleate and hydrochlorothiazide Aa-amilzide Hydrochlorothiazide Tab 25mg Apo-irbesartan/hctz Valsartan and hydrochlorothiazide Ag-candesartan HCT Benicar Hct Riva-zide 50/25mg Tablets Aldactazide 50 Auro-irbesartan HCT Lisinopril/hctz (type Z) Jamp-olmesartan Hctz Valsartan-hctz Aldoril Valsartan/htcz Metoprolol Succinate and Hydrochlorothiazide Teva-olmesartan / Hctz Quinaretic Ag-irbesartan Hctz Spironolactone and Hydrochlorothiazide Ziac PMS-ramipril-hctz Sandoz Lisinopril HCT PHL-hydrochlorothiazide Tekturna HCT Benicar HCT TELMISARTAN and HYDROCHLOROTHIAZIDE Nra-telmisartan/hctz Prinzide Pritorplus Nu-triazide Tab 50 Mg/25 mg Irbesartan/hct Telmisartan/hctz Ami-hydro Tab Novo-doparil 25 Tab Quinapril Hydrochloride/Hydrochlorothiazide Act Candesartan/hct Candesartan/hctz Micardis Plus Irbesartan / Hydrochlorothiazide Teva Ag-losartan Hctz Novo-doparil 15 Tab Teva-olmesartan/hctz Teva-hydrochlorothiazide Teva-irbesartan/hctz Ntp-hydrochlorothiazide Hydrochlorothiazide 100 Tab Olmetec Plus Teva-ramipril/hctz Truemed Group LLC Inhibace Plus Candesartan-hctz Ntp-telmisartan Hctz Uniretic PMS-losartan-hctz Amiloride Hydrochloride and Hydrochlorothiazide Hydrochlorothiazide Tablets 50mg Pendo-irbesartan-hctz Septa-candesartan Hctz Auro-valsartan HCT Nu-hydro Van-telmisartan-hctz Mylan-losartan Hctz Teva-lisinopril/hctz (type Z) Mylan-telmisartan Hctz Novo-valsartan/hctz Act Losartan/hct Sandoz Candesartan Plus Apo-quinapril / Hctz Tablets Hydrochlorothiazide Tab 50mg Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide 20/5/12.5 mg Apo-lisinopril/hctz Apo-quinapril/hctz Apo-hydrochlorothiazide Ag Telmisartan-hct Irbesartan-hctz Ntp-lisinopril/hctz (type P) Lisinopril with Hydrochlorothiazide Ach-telmisartan Hctz Irbesartan Hydrochlorothiazide Zentiva Teveten Plus Auro-losartan HCT Jamp Candesartan-hct Hydrodiuril Tab 50mg Dutoprol Auro-olmesartan Hctz
Indication	Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy.[L8447,L8450] Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.[A185138,L8447,L8450,L45663]
Categories	Amides Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Benzothiadiazines Cardiovascular Agents Diuretics Drugs causing inadvertant photosensitivity Genito Urinary System and Sex Hormones Gynecological Antiinfectives and Antiseptics Heterocyclic Compounds, Fused-Ring Hyperglycemia-Associated Agents Hypotensive Agents Increased Diuresis Low-Ceiling Diuretics and Potassium-Sparing Agents Membrane Transport Modulators Natriuretic Agents Nephrotoxic agents Non Potassium Sparing Diuretics OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Substrates Photosensitizing Agents Potential QTc-Prolonging Agents QTc Prolonging Agents Sodium Chloride Symporter Inhibitors Sulfonamides Sulfones Sulfur Compounds Thiazides
ATC-Code	C09BX03 C03AX01 C03AB03 C09DX03 C03EA01 C09DX06 C09XA52 G01AE10 C09DX01 C03AA03 C09XA54 C09DX08 C09DX07
CAS number	58-93-5

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Solute carrier family 12 member 3	MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSST...	unknown	inhibitor
Angiotensin-converting enzyme	MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFA...	unknown	modulator
Calcium-activated potassium channel subunit alpha-1	MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSS...	unknown	inhibitor
Albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	substrate,inhibitor
Organic anion transporter 3	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
Solute carrier family 22 member 11	MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCW...	unknown	substrate
ATP-binding cassette sub-family C member 4	MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPE...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL435
PubChem	3639
ChEMBL	CHEMBL435
ChEBI	CHEBI:5778
CCDC/CSD	KASMOH, HCSBTZ01, HCSBTZ02, LOLZOE, HCSBTZ08, DADNEE, PIRYAS, HCSBTZ04, DADMUT, HCSBTZ05, CASCAB, NOLCAV, LOLZEU, CASMAL, PIRXUL, EGENIP02, MUPPIX, HCSBTZ03, NOLCEZ, PIRXOF, HCSBTZ06, HCSBTZ07, ODATIX, ODEFEJ, VITWIE, BANPAK, PIRLUZ, EGENOV, SIZZUZ, DADMED, DADMIH, EGENIP, DADMED01, EGENIP01, DADNAA, HCSBTZ, EGENUB, NOLBOI, NOLBOI01, SOBBAP, REZXEZ, EGEPAJ, OBAFIK, HCSBTZ09
COD	2211088, 2206412, 2206455, 2206674, 2206702, 2103079, 4502543, 7216244, 7216241, 7217346, 7217349, 2105753, 2105754, 2105755, 2105756, 2208938, 2209149, 1551861, 1551862, 1551863, 1551864