HFZ
6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Find entries where: HFZ
is present as a standalone ligand in 1 entries
Chemical Component Summary | |
|---|---|
| Name | 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide |
| Identifiers | 1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide |
| Formula | C8 H8 F3 N3 O4 S2 |
| Molecular Weight | 331.292 |
| Type | NON-POLYMER |
| Isomeric SMILES | c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)N)C(F)(F)F |
| InChI | InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) |
| InChIKey | DMDGGSIALPNSEE-UHFFFAOYSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 28 |
| Chiral Atom Count | 0 |
| Bond Count | 29 |
| Aromatic Bond Count | 6 |
Drug Info: DrugBank
| DrugBank ID | DB00774? |
|---|---|
| Name | Hydroflumethiazide |
| Groups |
|
| Description | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) |
| Synonyms |
|
| Brand Names | Saluron |
| Indication | Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. |
| Categories |
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| ATC-Code |
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| CAS number | 135-09-1 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Solute carrier family 12 member 1 | MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSF... | unknown | inhibitor |
| Carbonic anhydrase 7 | MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLE... | unknown | inhibitor |
| Carbonic anhydrase 9 | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLG... | unknown | inhibitor |
| Sodium/potassium-transporting ATPase subunit alpha-1 | MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDE... | unknown | inducer |
| Calcium-activated potassium channel subunit alpha-1 | MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSS... | unknown | inducer |
| View More | |||
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| Pharos | CHEMBL1763 |
| PubChem | 3647 |
| ChEMBL | CHEMBL1763 |
| ChEBI | CHEBI:5784 |
| CCDC/CSD | EWUHAF01, EWUHAF |
| COD | 2215689 |
