HIS

HISTIDINE

Find entries where: HIS

is present as a standalone ligand in 100 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 7 entries

is present in a polymer sequence 214,540 entries

Find related ligands:

Similar Ligands (Stereospecific)

Similar Ligands (Quick Screen)

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	HISTIDINE
Identifiers	(2S)-2-amino-3-(1H-imidazol-3-ium-4-yl)propanoic acid
Formula	C₆ H₁₀ N₃ O₂
Molecular Weight	156.162
Type	L-PEPTIDE LINKING
Isomeric SMILES	c1c([nH+]c[nH]1)C[C@@H](C(=O)O)N
InChI	InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/p+1/t5-/m0/s1
InChIKey	HNDVDQJCIGZPNO-YFKPBYRVSA-O

Chemical Details
Formal Charge	1
Atom Count	21
Chiral Atom Count	1
Bond Count	21
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB00117 ?
Name	Histidine
Groups	investigational nutraceutical
Description	An essential amino acid that is required for the production of histamine.
Synonyms	(S)-α-amino-1H-Imidazole-4-propanoic acid L-Histidine Histidina HIS L-(?)-histidine Histidine Copper histidine (S)-4-(2-Amino-2-carboxyethyl)imidazole (S)-alpha-amino-1H-Imidazole-4-propanoic acid L-Histidin Histidine monohydrochloride monohydrate (S)-alpha-Amino-1H-imidazole-4-propionic acid (S)-a-Amino-1H-imidazole-4-propanoic acid
Brand Names	Olimel 5.7% 20% Prosol Essepna 8.5% Freamine III Aminosyn 10% W Electrolytes Aminosyn II 10% With Electrolytes Trepoxicam-7.5 Aminosyn 5% Aminosyn II in Dextrose Aminosyn II 7% Injection Olimel 7.6% E ProSol CAREDO Treating Periodontitis Toothpastes 100g Travasol Amino Acid Inj 5.5% Travasol Inj Without Electrolytes 5.5% Aminosyn II 7% M In 10% Dextrose(dual Chamber) 4.25% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn II 8.5% With 50% Dextrose Kabiven 2.5% Travasol Amino Acid Injection Without Electrolytes In 10% Dextrose Quickmix Vamin N FreAmine HBC Perikabiven Nephramine Liq IV Aminosyn II and Dextrose 4.25% Travasol Amino Acid Injection Without Electrlytes In 10% Dextrose HepatAmine Aminosyn II 7% With 50% Dextrose 2.75% Travas. Amino Acid InJ.W.elecw.25%dex ProcalAmine Aminosyn II 8.5% Injection FreAmine III Olimel 4.4% Clinimix Aminosyn II 5% Inj Clinimix E Olimel 7.6% 2.75% Travasol Amino Acid Injection With Electrolytes In 5% Dextrose Quickmix Aminosyn 3.5% M Aminosyn-PF 4.25% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Aminosyn II Aminosyn II with Electrolytes Aminosyn NephrAmine Hepatasol Aminosyn II 8.5% M In 20% Dextrose (dual Chamber) Synthamin Plenamine Aminosyn II with Electrolytes in Dextrose with Calcium Smofkabiven Extra Nitrogen Electrolyte Free 4.25%trav. Amino Acid InJ.W.O.elect.5%dext. 4.25%travasol Amino Acid InJ.W.elecw.5%dex. Aminosyn Sulfite Free Clinisol Vamin 18 Electrolyte-free Travasol Inj Without Electrolytes 8.5% Premasol - sulfite-free (Amino Acid) Olimel 4.4% E Primene 10%-liq IV Aminosyn-PF 10% Primene Novamine 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Clinimix Periolimel 2.5% E Trepoxen-250 4.25% Amino Acid Injection Without Electrolytes In 20% Dextrose Quickmix Aminosyn 8.5% Aminosyn RF Injection 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Travasol Amino Acid Inj 8.5% 5% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Travasol Nutrineal Pd4 Olimel 3.3% E Aminosyn-PF 7% Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose Injec 4.25% Travasol Amino Acid Without Electrolytes In 5% Dextrose Quickmix 4.25% Travasol Amino Acid Injection Without Electrolytes In 25% Dextrose Aminosyn HF Aminosyn 7% 2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Olimel 5.7% E Smofkabiven Aminosyn II In Dextrose Injection 5% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose Aminosyn 8.5% Injection With Electrolytes 5% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose 2.5%travasol Amino Acid InJ.W.eleC.W.25%dex 4.25% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Smofkabiven Electrolyte Free 2.75% Travasol Amino Acid Injection With Electrolytes In 25% Dextrose Quickmix 4.25% Travasol Amino Acid Injection With Electrolytes In 20% Dextrose Quickmix Smofkabiven Extra Nitrogen Clinimix 2.5% Travasol Aa Without Electrolytes In 10% Dextrose Injec 2.75%travasol Amino Acid InJ.W.eleC.W.5%dex. Primene 10% Travasol E Renamin (amino Acids) Injection Aminosyn II 7% With 10% Dextrose Aminosyn RF TrophAmine Smofkabiven Peripheral 4.25% Travasol Amino Acid Injection Without Electrolytes In 20% Dextrose RenAmin
Indication	The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
Categories	Amino Acids Amino Acids, Cyclic Amino Acids, Essential Amino Acids, Peptides, and Proteins Dietary Supplements Proteinogenic Amino Acids Supplements
CAS number	71-00-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Histidine decarboxylase	MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPED...	unknown
Histidine--tRNA ligase, cytoplasmic	MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDES...	unknown
Sodium-coupled neutral amino acid transporter 3	MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCMEGKSFLQ...	unknown
Histidine ammonia-lyase	MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDD...	unknown
Monocarboxylate transporter 10	MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVEL...	unknown	substrate,inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682