HUP

Huperzine A

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is present as a standalone ligand in 3 entries

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Chemical Component Summary
Name	Huperzine A
Identifiers	n/a
Formula	C₁₅ H₁₈ N₂ O
Molecular Weight	242.316
Type	NON-POLYMER
Isomeric SMILES	C/C=C/1\[C@@H]2CC3=C([C@]1(CC(=C2)C)N)C=CC(=O)N3
InChI	InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
InChIKey	ZRJBHWIHUMBLCN-YQEJDHNASA-N

Chemical Details
Formal Charge	0
Atom Count	36
Chiral Atom Count	2
Bond Count	38
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB04864 ?
Name	Huperzine A
Groups	approved experimental
Description	Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss _Huperzia serrata_. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer’s disease.
Synonyms	Huperzine-A L-huperzine A Selagine Huperzine A (?)-huperazine A (-)-Huperzine A (?)-selagine
Indication	Investigated for use/treatment in alzheimer's disease.
Categories	Central Nervous System Agents Cholinergic Agents Cholinesterase Inhibitors Compounds used in a research, industrial, or household setting Enzyme Inhibitors Neuroprotective Agents Neurotransmitter Agents Protective Agents Terpenes
CAS number	102518-79-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Acetylcholinesterase	MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682