HXA

DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID

Find entries where: HXA

is present as a standalone ligand in 15 entries

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Chemical Component Summary
Name	DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID
Identifiers	(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid
Formula	C₂₂ H₃₂ O₂
Molecular Weight	328.488
Type	NON-POLYMER
Isomeric SMILES	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)O
InChI	InChI=1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
InChIKey	MBMBGCFOFBJSGT-KUBAVDMBSA-N

Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	0
Bond Count	55
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB03756 ?
Name	Doconexent
Groups	approved investigational
Description	A mixture of fish oil and primrose oil, doconexent is used as a high-docosahexaenoic acid (DHA) supplement. DHA is a 22 carbon chain with 6 cis double bonds with anti-inflammatory effects. It can be biosythesized from alpha-linolenic acid or commercially manufactured from microalgae. It is an omega-3 fatty acid and primary structural component of the human brain, cerebral cortex, skin, and retina thus plays an important role in their development and function. The amino-phospholipid DHA is found at a high concentration across several brain subcellular fractions, including nerve terminals, microsomes, synaptic vesicles, and synaptosomal plasma membranes [A19436].
Synonyms	22:6-4, 7,10,13,16,19 docosa-4,7,10,13,16,19-hexaenoic acid all-cis-4,7,10,13,16,19-docosahexaenoic acid 22:6(n-3) all-cis-DHA Docosahexaenoic acid cervonic acid (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid Doconexent sodium 4,7,10,13,16,19-docosahexaenoic acid Docosahexanoic Acid DHA Doconexent
Brand Names	Natalvirt Ca Se-Tan DHA Choice OB DHA Triveen-PRx RNF Virt-Select PRENATAL/POSTNATAL NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Paire OB Plus DHA OB Complete Petite Nestabs ONE Pnv-OB-dha Virt-Care One Taliva Prenate DHA Foltabs Prenatal Plus DHA Virt-PN Plus Virt-C DHA Prena1 Renate DHA Ultimate OB DHA Vitaphil DHA Animi-3 with Vitamin D Virt-Bal DHA Plus Folcaps Omega-3 vitaMedMD Rx Plus PNV-Omega Select-OB Plus DHA Prenatal Supplement Plus DHA Natalvirt 90dha BP Vit 3 Vp-CH-pnv Super Omega 3 Vp-pnv-dha Premium Omega 3 Folcaps Care One VP-HEME One Prena1 Plus Prenate Essential VITAFOL Gummies vitaMedMD One Rx Active OB CitraNatal Harmony WesNatal DHA Complete Dothelle DHA Oveeza PRENATE Restore TL-Care DHA Prenatal, DHA UltimateCare ONE NF Renate VemaVite-PRx 2 with Fish-Based DHA Zatean-Pn DHA Provida DHA Multinate DHA Vitafol Ultra Folivane-PRx DHA A2A Omega-3 TL-Select Triveen-Duo DHA A2A Omega 3 VirtPrex Pnv Ob DHA Folcal DHA Tricare Prenatal DHA One With Folate Vitafol Fe Plus PreNexa premier NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Zatean-CH Cavan Folate DHA Tricare Prenatal Twist-off DHA Soft Quick Dissolve Re Ob 90 DHA Animi-3 Virt-Pn DHA Cavan One Herbalifeline Luvira Tendera-OB PreNexa CitraNatal Essence Prenaissance Protect Cardio AF CitraNatal Assure Vitaphil 90 DHA Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA CitraNatal DHA Rulavite DHA PreQue 10 WestGel DHA CitraNatal Harmony 3.0 Obstetrix DHA Combo Pack Focalgin 90 DHA natelle COMPLETE WesCap-C-DHA Docosavit Folet One Nexa Select Nutri-Tab OB plus DHA Natelle One Tricare Prenatal DHA One Rx Multivitamin HemeNatal OB plus DHA OB Complete 400 Focalgin CA Omega-3 Iq Childrens Chewable Multinate DHA Extra Taliment Tricare Prenatal Compleat CitraNatal Medley Pnv-dha VP CH Plus PRENATE Enhance TriStart DHA PreFol-DHA Se-Plete DHA PreferaOB One Taron-prex Prenatal Calcium PNV Ultra Omega 3 OBTREX DHA Combo Pack Zatean-Pn Plus WesCap-PN DHA Iron Polysaccharides Folic Acid DHA Tricare Prenatal 2-part Daily Prenatal Vitamin System Extra-Virt Plus DHA Obtrex One Obstetrix ONE Complete Natal DHA Prenaissance Plus VP CH Ultra Gesticare DHA Vitafol-OB Plus DHA Prenatal Supplement Plus DHA Folet DHA Tricare Prenatal DHA One Prenate Mini Virt-PN DHA
Indication	Used as a high-docosahexaenoic acid (DHA) oral supplement.
Categories	Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dietary Fats Dietary Fats, Unsaturated Fats Fatty Acids Fatty Acids, Omega-3 Fatty Acids, Unsaturated Fish Oils Lipids Oils
CAS number	6217-54-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Peroxisome proliferator-activated receptor alpha	MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFG...	unknown	activator
Peroxisome proliferator-activated receptor gamma	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL...	unknown	activator
Retinoic acid receptor RXR-alpha	MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSP...	unknown	activator
Retinoic acid receptor RXR-beta	MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAA...	unknown	activator
Retinoic acid receptor RXR-gamma	MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPV...	unknown	activator
Sterol regulatory element-binding protein 1	MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPP...	unknown	inhibitor
Myc proto-oncogene protein	MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIW...	unknown	inhibitor
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	substrate,inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682