IPH

PHENOL

Created:	1999-07-08
Last modified:	2011-06-04

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114 entries where IPH is found as a standalone ligand3 entries where IPH is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	13
Chiral Atom Count	0
Bond Count	13
Aromatic Bond Count	6

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Chemical Component Summary
Name	PHENOL
Systematic Name (OpenEye OEToolkits)	phenol
Formula	C₆ H₆ O
Molecular Weight	94.111
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	Oc1ccccc1
SMILES	CACTVS	3.341	Oc1ccccc1
SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)O
Canonical SMILES	CACTVS	3.341	Oc1ccccc1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1ccc(cc1)O
InChI	InChI	1.03	InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
InChIKey	InChI	1.03	ISWSIDIOOBJBQZ-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

DrugBank ID	DB03255 ?
Name	Phenol
Groups	experimental approved
Description	Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization. Research indicates that parental exposure to phenol and its related compounds are positively associated with spontaneous abortion. During the second world war, phenol injections were used as a means of execution by the Nazis. Phenol is a toxic compound whose vapours are corrosive to the skin, eyes, and respiratory tract.
Synonyms	Phenol Hydroxybenzene Phenylic acid Carbols?ure Phenyl hydroxide Acide carbolique PHOH Phenylic alcohol Monohydroxybenzene Phenyl alcohol Carbolic acid Karbols?ure Phenic Acid Acide phénique Fenol Oxybenzene Benzenol
Brand Names	Blistex Complete Care (Blistex Lip Medex, Blistex Medicated Lip, Blistex Five Star Lip Protection Broad Spectrum, and Blistex Complete Moisture) NICE SORE THROAT Cherry Pain A Lay Rugby Cherry Flavor CVS Health Sore Throat Fast Relief Oral Anesthetic Phenaseptic Cherry CVS Health Maximum Strength Sore Throat Fast Relief Preferred Plus Medicated Lip Balm Medicated Lipbalm Throat Relief Ozonol Ont Medicated Lip Balm Sore throat cherry Sore Throat Relief Cherry Campho-Phenique Pain Relieving Antiseptic Liquid Leader Sore Throat Vaseline Brand Lip Therapy Medicated Tube Sterile Diluent for Allergenic Extract Chloraseptic Warming Sore Throat HEB Sore Throat Menthol Flavor Calamine Phenolated Topical Suspension Liver supplement Walgreens Sore Throat Cherry Flavor ABSORBINE jr. Sore Throat Menthol Instant Antiseptic Pain Relief Vicks Formula 44 Sore Throat Ulcerease CAMPHO-PHENIQUE ANTISEPTIC Gel PUBLIX Sore Throat Menthol Flavor Vortex Moisturizer Oral Premier Value Instant Antiseptic Pain Relief Leader Sore throat Sunmark Sore Throat BiteMD External Analgesic First Aid Antiseptic Good Neighbor Pharmacy Sore Throat Sting-eze-liq Carmex Lip Balm NICE SORE THROAT Honey Lemon Walgreens Camphor Phenol Gel Bite Relief Pain Relieving Petro Carbo Blistex Medicated Lip Balm Variety Pack (Blistex Medicated Berry Lip Balm, Blistex Medicated Lip Balm, Blistex Medicated Lip) Topcare Cold Sore Treatment Chloraseptic Sore Throat Carmex Lip Ointment Care One Sore Throat Lip Conditioner Lip Balm Equate Sore Throat Oral Relief Phenol Saline Inj Campho-Phenique Antiseptic HEB Sore Throat Cherry Flavor Chapstick Medicated Lip Balm - Jar Absorbine Jr Pro Cream OFF Bite and Itch Relief First Aid Antiseptic Phylorinol CAMPHOR (SYNTHETIC) and PHENOL Absorbine Jr Pro No Mess Roll-on Plus DRx Choice Sore Throat Menthol Flavor Smart Sense Sore Throat PUBLIX Sore Throat Fast Relief Oral Anesthetic Phenoris Ont Sore Throat Relief Cherry Flavor ZYCAZIN Antiseptic Liquid Fortinia ID Leader Camphor Phenol Gel Castellani Paint Budpak First Aid Blistex con Medicacion Crema Labial Blistex Lip eos Medicated Pain Relieving Lip Balm Poison Oak Campho Phenique Cold Sore Treatment Shopko Camphor Phenol Gel Blistex Medicated Kank-A with Blistex Medicated Lip ChigaRid Chloraseptic Sore Throat Citrus Anbesol Gel ChapIce Camphor Phenol Gel NICE SORE THROAT Spearmint Topcare Sore Throat Chloraseptic Sore Throat Menthol Good Sense Sore Throat Healthy Accents Sore Throat Labisan Meijer Sore Throat Phen-oris - Ont Top Chapstick Medicated Dermaphy Ont Diluent Sterile Ambix First Aid MAKESENSE First Aid First Aid Sore Throat Relief Menthol Campho-Phenique Cold Sore Treatment Sting Kure - Liq Aseptil Rojo Glycerinated Phenol Saline Chapstick Medicated Lip Balm - Tube Sore Throat Relief Sore Throat Coghlan s Sting Relief Anbesol Maximum Strength Liquid Banana Boat Medicated Lip Balm Diluent for Allergenic Extract Sterile Normal Saline With Phenol (0.4%) Good Neighbor Sore Throat Cherry Flavor CVS Camphor Phenol Gel Au Kah Chuen Skin Lotion Major Camphor and Phenol Sore Throat Cherry Cepastat Cherry CareOne Cold Sore Treatment Poison Oak and Ivy Sting Eze StingEze Max Insect Bite Relief Wild Horse 777 Oral DDM Instant Antiseptic Pain Relief meijer Maximum Strength Sore Throat Fast Relief Blistex Dct Anbesol Liquid Rx Act Sore Throat TopCare Cherry Flavor Dg Health Sore Throat Sunmark sore throat Labisan Cold Sore Dermagesic Yat Tip Xiao Equaline Sore Throat Blistex Lip Medex Freds Antiseptic Instant Pain Relief Phenol Cold Sore Treatment Sore Throat ReadyInCase Phenol 6% Maximum Strength Cold Sore Treatment Exchange Select Cold Sore Treatment Chloraseptic Sore Throat Max Sunmark Phenolated Calamine Abridge Cold Sore Treatment Medicated Blistex Dct Lip Balm Balzarol Ont Boil Ease Drawing Salve Ont Topcare Sore Throat Menthol Flavor ABC Sore Throat Menthol Flavor Blistex Medicated Variety Pack (Blistex Medicated Berry Lip Balm, Blistex Medicated Lip Balm, Blistex Medicated Lip) Castellani Paint 1.5% Signature Care Maximum Strength Cold Sore Treatment Chapstick Medicated Lip Balm - Stk Chloraseptic Sore Throat Cherry Bite and Sting Relief Stick Natur 911 Chigarid Vida Mia Instant Antiseptic Pain Relief Mecca Ointment HEB Camphor Phenol StingEze Insect Bite Relief Chloraseptic Sore Throat (Kids Grape) Grape Cepastat Extra Strength
Indication	Phenol is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity.
Categories	Anesthetics Anesthetics, Local Anti-Infective Agents Anti-Infective Agents, Local Antiseptics and Disinfectants Antivaricose Therapy Benzene Derivatives Cardiovascular Agents Compounds used in a research, industrial, or household setting Dermatologicals Disinfectants Miscellaneous Therapeutic Agents Nervous System Pharmaceutical Preparations Pharmaceutical Solutions Phenol and Derivatives Phenols Sclerosing Agents for Local Injection Sclerosing Solutions Solutions Throat Preparations Vasoprotectives
ATC-Code	C05BB05 R02AA19 N01BX03 D08AE03
CAS number	108-95-2

Drug Targets

DrugBank data are sourced from datasets licensed under a Creative Common's Attribution-NonCommercial 4.0 International License

Name	Target Sequence	Pharmacological Action	Actions
Carbonic anhydrase 1	MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISV...	unknown	inhibitor
Carbonic anhydrase 4	MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDR...	unknown	inhibitor
Carbonic anhydrase 12	MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSC...	unknown	inhibitor
Carbonic anhydrase 2	MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS...	unknown	inhibitor
Carbonic anhydrase 14	MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDI...	unknown	inhibitor
Carbonic anhydrase 9	MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLG...	unknown	inhibitor
Albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown
Thermolysin	MKMKMKLASFGLAAGLAAQVFLPYNALASTEHVTWNQQFQTPQFISGDLL...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	996, 20488062
ChEMBL	CHEMBL14060
ChEBI	CHEBI:15882
CCDC/CSD	AGOKEN, JIMRON, DEVXOS, JUCYAH, AGOTEV, DIKSAS, FOTBAR, FOTBAR10, JECJAC, EBILOR, LAWWOW, EREKAN, JECHUU, LUNCAB, GOKPAA, CAFVOW, FAJYOF, GOKPAA01, HIBFON, FINPUN, HIBFED, DILSOI, ISEKAS, OLAQAT, MARCIT, BOPDAO, LASXUY, HIBFIH, LODLIB, FORQUB, MITGEB, MPPZPO, GIXNOQ, COHWOL, CUXMOA, KACKOS, AZEZEN
COD	2103472