JEV
N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide
Find entries where: JEV
is present as a standalone ligand in 5 entries
Chemical Component Summary | |
|---|---|
| Name | N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide |
| Synonyms | Ramelteon |
| Identifiers | ~{N}-[2-[(8~{S})-2,6,7,8-tetrahydro-1~{H}-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide |
| Formula | C16 H21 N O2 |
| Molecular Weight | 259.343 |
| Type | NON-POLYMER |
| Isomeric SMILES | CCC(=O)NCC[C@@H]1CCc2c1c3c(cc2)OCC3 |
| InChI | InChI=1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1 |
| InChIKey | YLXDSYKOBKBWJQ-LBPRGKRZSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 40 |
| Chiral Atom Count | 1 |
| Bond Count | 42 |
| Aromatic Bond Count | 6 |
Drug Info: DrugBank
| DrugBank ID | DB00980? |
|---|---|
| Name | Ramelteon |
| Groups |
|
| Description | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. |
| Synonyms | Ramelteon |
| Brand Names |
|
| Indication | For the treatment of insomnia characterized by difficulty with sleep onset. |
| Categories |
|
| ATC-Code | N05CH02 |
| CAS number | 196597-26-9 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Melatonin receptor type 1B | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVT... | unknown | multitarget |
| Melatonin receptor type 1A | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVIL... | unknown | multitarget |
| Cytochrome P450 2C19 | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDV... | unknown | substrate |
| Cytochrome P450 3A4 | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI... | unknown | substrate |
| Cytochrome P450 2C9 | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI... | unknown | substrate |
| View More | |||
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| Pharos | CHEMBL1218 |
| PubChem | 208902 |
| ChEMBL | CHEMBL1218 |
| ChEBI | CHEBI:109549 |
| CCDC/CSD | NOKGEC |
| COD | 1552850 |
