KAN

KANAMYCIN A

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is present as a standalone ligand in 26 entries

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Chemical Component Summary
Name	KANAMYCIN A
Identifiers	(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-oxane-3,4,5-triol
Formula	C₁₈ H₃₆ N₄ O₁₁
Molecular Weight	484.499
Type	NON-POLYMER
Isomeric SMILES	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N
InChI	InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1
InChIKey	SBUJHOSQTJFQJX-NOAMYHISSA-N

Chemical Details
Formal Charge	0
Atom Count	69
Chiral Atom Count	15
Bond Count	71
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB01172 ?
Name	Kanamycin
Groups	approved investigational vet_approved
Description	Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate.
Synonyms	4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside Kanamycin sulfate Kanamycin 4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-α-D-glucoside Kanamycin A
Brand Names	Kantrex Kanamycin
Indication	For treatment of infections where one or more of the following are the known or suspected pathogens: <i>E. coli</i>, <i>Proteus</i> species (both indole-positive and indole-negative), <i>E. aerogenes, K. pneumoniae, S. marcescens,</i> and <i>Acinetobacter</i> species.
Categories	Agents that produce neuromuscular block (indirect) Alimentary Tract and Metabolism Aminoglycoside Antibacterials Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Antiinfectives for Systemic Use Carbohydrates Drugs that are Mainly Renally Excreted Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index Enzyme Inhibitors Glycosides Intestinal Antiinfectives Narrow Therapeutic Index Drugs Nephrotoxic agents Ophthalmologicals Protein Synthesis Inhibitors Sensory Organs
ATC-Code	S01AA24 J01GB04 A07AA08
CAS number	59-01-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
30S ribosomal protein S12	MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALR...	unknown	inhibitor
16S ribosomal RNA	-	unknown	inhibitor
Aminoglycoside 2'-N-acetyltransferase	MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHA...	unknown	substrate
Kanamycin nucleotidyltransferase	MNGPIIMTREERMKIVHEIKERILDKYGDDVKAIGVYGSLGRQTDGPYSD...	unknown	substrate
Aminoglycoside 3'-phosphotransferase	MSHIQRETSCSRPRLNSNLDADLYGYKWARDNVGQSGATIYRLYGKPDAP...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682