Chemical Component Summary | |
|---|---|
| Name | LATRUNCULIN B |
| Identifiers | (4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one |
| Formula | C20 H29 N O5 S |
| Molecular Weight | 395.513 |
| Type | NON-POLYMER |
| Isomeric SMILES | C[C@H]\1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)\C=C(/CC\C=C1)\C |
| InChI | InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1 |
| InChIKey | NSHPHXHGRHSMIK-JRIKCGFMSA-N |
Chemical Details | |
|---|---|
| Formal Charge | 0 |
| Atom Count | 56 |
| Chiral Atom Count | 5 |
| Bond Count | 58 |
| Aromatic Bond Count | 0 |
Drug Info: DrugBank
| DrugBank ID | DB08080? |
|---|---|
| Name | Latrunculin B |
| Groups | experimental |
| Description | Latrunculin B is a 14-membered macrolide attached to 2-thiazolidinone moiety, isolated from Red Sea sponge _Latrunculia magnifica_. |
| Synonyms |
|
| Categories |
|
| CAS number | 76343-94-7 |
Drug Targets
| Name | Target Sequence | Pharmacological Action | Actions |
|---|---|---|---|
| Actin, alpha skeletal muscle | MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMG... | unknown | |
| MKL/myocardin-like protein 1 | MPPLKSPAAFHEQRRSLERARTEDYLKRKIRSRPERSELVRMHILEETSA... | unknown | |
| Protein spire homolog 2 | MARAGSCGGAAAGAGRPEPWELSLEEVLKAYEQPLNEEQAWAVCFQGCRG... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
| Resource Name | Reference |
|---|---|
| PubChem | 6436219 |
| ChEMBL | CHEMBL411879 |
| ChEBI | CHEBI:49703 |
